Association between the apoptotic effect of Cabazitaxel and its pro-oxidant efficacy on the redox adaptation mechanisms in prostate cancer cells with different resistance phenotypes

Association between the apoptotic effect of Cabazitaxel and its pro-oxidant efficacy on the redox adaptation mechanisms in prostate cancer cells with different resistance phenotypes

ABSTRACTRedox adaptation causes poor prognosis by adapting cancer cells to excessive oxidative stress. Previously, we introduced an oxidative stress-resistant metastatic prostate cancer (mPC) model (LNCaP-HPR) that redox adaptation reduced the effect of Cabazitaxel (Cab), the last taxane-derivative...

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Bibliographic Details
Main Authors: Isil Ezgi Eryilmaz, Unal Egeli, Gulsah Cecener
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Cancer Biology & Therapy
Subjects:
Cabazitaxel
prostate cancer
redox adaptation
Nrf-2
NF-κB
HIF-1α
Online Access:https://www.tandfonline.com/doi/10.1080/15384047.2024.2329368

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https://www.tandfonline.com/doi/10.1080/15384047.2024.2329368

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