The effect of crystalloid <it>versus</it> medium molecular weight colloid solution on post-operative nausea and vomiting after ambulatory gynecological surgery - a prospective randomized trial
<p>Abstract</p> <p>Background</p> <p>Intravenous fluid is recommended in international guidelines to improve patient post-operative symptoms, particularly nausea and vomiting. The optimum fluid regimen has not been established. This prospective, randomized, blinded stud...
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| Format: | Article |
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BMC
2012-07-01
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| Series: | BMC Anesthesiology |
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| Online Access: | http://www.biomedcentral.com/1471-2253/12/15 |
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| author | Hayes Ivan Rathore Raza Enohumah Kingsley Mocanu Edgar Kumar Deepak McCaul Conan |
| author_facet | Hayes Ivan Rathore Raza Enohumah Kingsley Mocanu Edgar Kumar Deepak McCaul Conan |
| author_sort | Hayes Ivan |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Intravenous fluid is recommended in international guidelines to improve patient post-operative symptoms, particularly nausea and vomiting. The optimum fluid regimen has not been established. This prospective, randomized, blinded study was designed to determine if administration of equivolumes of a colloid (hydroxyethyl starch 130/0.4) reduced post operative nausea and vomiting in healthy volunteers undergoing ambulatory gynecologic laparoscopy surgery compared to a crystalloid solution (Hartmann’s Solution).</p> <p>Methods</p> <p>120 patients were randomized to receive intravenous colloid (N = 60) or crystalloid (N = 60) intra-operatively. The volume of fluid administered was calculated at 1.5 ml.kg<sup>-1</sup> per hour of fasting. Patients were interviewed to assess nausea, vomiting, anti-emetic use, dizziness, sore throat, headache and subjective general well being at 30 minutes and 2, 24 and 48 hours post operatively. Pulmonary function testing was performed on a subgroup.</p> <p>Results</p> <p>At 2 hours the proportion of patients experiencing nausea (38.2 % <it>vs</it> 17.9%, P = 0.03) and the mean nausea score were increased in the colloid compared to crystalloid group respectively (1.49 ± 0.3 <it>vs</it> 0.68 ± 0.2, P = 0.028). The incidence of vomiting and anti-emetic usage was low and did not differ between the groups. Sore throat, dizziness, headache and general well being were not different between the groups. A comparable reduction on post-operative FVC and FEV-1 and PEFR was observed in both groups.</p> <p>Conclusions</p> <p>Intra-operative administration of colloid increased the incidence of early postoperative nausea and has no advantage over crystalloid for symptom control after gynaecological laparoscopic surgery.</p> |
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| issn | 1471-2253 |
| language | English |
| last_indexed | 2024-04-12T22:18:48Z |
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| series | BMC Anesthesiology |
| spelling | doaj.art-aca29405c515447fb0efd2a182f815672022-12-22T03:14:27ZengBMCBMC Anesthesiology1471-22532012-07-011211510.1186/1471-2253-12-15The effect of crystalloid <it>versus</it> medium molecular weight colloid solution on post-operative nausea and vomiting after ambulatory gynecological surgery - a prospective randomized trialHayes IvanRathore RazaEnohumah KingsleyMocanu EdgarKumar DeepakMcCaul Conan<p>Abstract</p> <p>Background</p> <p>Intravenous fluid is recommended in international guidelines to improve patient post-operative symptoms, particularly nausea and vomiting. The optimum fluid regimen has not been established. This prospective, randomized, blinded study was designed to determine if administration of equivolumes of a colloid (hydroxyethyl starch 130/0.4) reduced post operative nausea and vomiting in healthy volunteers undergoing ambulatory gynecologic laparoscopy surgery compared to a crystalloid solution (Hartmann’s Solution).</p> <p>Methods</p> <p>120 patients were randomized to receive intravenous colloid (N = 60) or crystalloid (N = 60) intra-operatively. The volume of fluid administered was calculated at 1.5 ml.kg<sup>-1</sup> per hour of fasting. Patients were interviewed to assess nausea, vomiting, anti-emetic use, dizziness, sore throat, headache and subjective general well being at 30 minutes and 2, 24 and 48 hours post operatively. Pulmonary function testing was performed on a subgroup.</p> <p>Results</p> <p>At 2 hours the proportion of patients experiencing nausea (38.2 % <it>vs</it> 17.9%, P = 0.03) and the mean nausea score were increased in the colloid compared to crystalloid group respectively (1.49 ± 0.3 <it>vs</it> 0.68 ± 0.2, P = 0.028). The incidence of vomiting and anti-emetic usage was low and did not differ between the groups. Sore throat, dizziness, headache and general well being were not different between the groups. A comparable reduction on post-operative FVC and FEV-1 and PEFR was observed in both groups.</p> <p>Conclusions</p> <p>Intra-operative administration of colloid increased the incidence of early postoperative nausea and has no advantage over crystalloid for symptom control after gynaecological laparoscopic surgery.</p>http://www.biomedcentral.com/1471-2253/12/15Fluid therapyColloidCrystalloid solutionsNauseaVomiting |
| spellingShingle | Hayes Ivan Rathore Raza Enohumah Kingsley Mocanu Edgar Kumar Deepak McCaul Conan The effect of crystalloid <it>versus</it> medium molecular weight colloid solution on post-operative nausea and vomiting after ambulatory gynecological surgery - a prospective randomized trial BMC Anesthesiology Fluid therapy Colloid Crystalloid solutions Nausea Vomiting |
| title | The effect of crystalloid <it>versus</it> medium molecular weight colloid solution on post-operative nausea and vomiting after ambulatory gynecological surgery - a prospective randomized trial |
| title_full | The effect of crystalloid <it>versus</it> medium molecular weight colloid solution on post-operative nausea and vomiting after ambulatory gynecological surgery - a prospective randomized trial |
| title_fullStr | The effect of crystalloid <it>versus</it> medium molecular weight colloid solution on post-operative nausea and vomiting after ambulatory gynecological surgery - a prospective randomized trial |
| title_full_unstemmed | The effect of crystalloid <it>versus</it> medium molecular weight colloid solution on post-operative nausea and vomiting after ambulatory gynecological surgery - a prospective randomized trial |
| title_short | The effect of crystalloid <it>versus</it> medium molecular weight colloid solution on post-operative nausea and vomiting after ambulatory gynecological surgery - a prospective randomized trial |
| title_sort | effect of crystalloid it versus it medium molecular weight colloid solution on post operative nausea and vomiting after ambulatory gynecological surgery a prospective randomized trial |
| topic | Fluid therapy Colloid Crystalloid solutions Nausea Vomiting |
| url | http://www.biomedcentral.com/1471-2253/12/15 |
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