Long-term impact of paediatric critical illness on the difference between epigenetic and chronological age in relation to physical growth

Long-term impact of paediatric critical illness on the difference between epigenetic and chronological age in relation to physical growth

Abstract Background Altered DNA-methylation affects biological ageing in adults and developmental processes in children. DNA-methylation is altered by environmental factors, trauma and illnesses. We hypothesised that paediatric critical illness, and the nutritional management in the paediatric inten...

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Main Authors: Ines Verlinden, Grégoire Coppens, Ilse Vanhorebeek, Fabian Güiza, Inge Derese, Pieter J. Wouters, Koen F. Joosten, Sascha C. Verbruggen, Greet Van den Berghe
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Clinical Epigenetics
Subjects:
Critical illness
Children
PICU
DNA methylation
Epigenetic
Epigenetic age
Online Access:https://doi.org/10.1186/s13148-023-01424-w

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