Plasma and Urinary Phenolic Profiles after Acute and Repetitive Intake of Wild Blueberry
Recent studies have shown that blueberries may have cardiovascular and cognitive health benefits. In this work, we investigated the profile of plasma and urine (poly)phenol metabolites after acute and daily consumption of wild blueberries for 30 days in 18 healthy men. The inter-individual variabili...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-08-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/21/9/1120 |
| _version_ | 1811218022204964864 |
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| author | Rodrigo P. Feliciano Geoffrey Istas Christian Heiss Ana Rodriguez-Mateos |
| author_facet | Rodrigo P. Feliciano Geoffrey Istas Christian Heiss Ana Rodriguez-Mateos |
| author_sort | Rodrigo P. Feliciano |
| collection | DOAJ |
| description | Recent studies have shown that blueberries may have cardiovascular and cognitive health benefits. In this work, we investigated the profile of plasma and urine (poly)phenol metabolites after acute and daily consumption of wild blueberries for 30 days in 18 healthy men. The inter-individual variability in plasma and urinary polyphenol levels was also investigated. Blood samples were collected at baseline and 2 h post-consumption on day 1 and day 30. Twenty-four-hour urine was also collected on both days. A total of 61 phenolic metabolites were quantified in plasma at baseline, of which 43 increased after acute or chronic consumption of blueberries over one month. Benzoic and catechol derivatives represented more than 80% of the changes in phenolic profile after 2 h consumption on day 1, whereas hippuric and benzoic derivatives were the major compounds that increased at 0 and 2 h on day 30, respectively. The total (poly)phenol urinary excretion remained unchanged after 30 days of wild blueberry intake. The inter-individual variability ranged between 40%–48% in plasma and 47%–54% in urine. Taken together, our results illustrate that blueberry (poly)phenols are absorbed and extensively metabolized by phase II enzymes and by the gut microbiota, leading to a whole array of metabolites that may be responsible for the beneficial effects observed after blueberry consumption. |
| first_indexed | 2024-04-12T07:02:53Z |
| format | Article |
| id | doaj.art-aca2f699881640688bcb58a6767cc9c2 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T07:02:53Z |
| publishDate | 2016-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-aca2f699881640688bcb58a6767cc9c22022-12-22T03:42:57ZengMDPI AGMolecules1420-30492016-08-01219112010.3390/molecules21091120molecules21091120Plasma and Urinary Phenolic Profiles after Acute and Repetitive Intake of Wild BlueberryRodrigo P. Feliciano0Geoffrey Istas1Christian Heiss2Ana Rodriguez-Mateos3Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf, GermanyDivision of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf, GermanyDivision of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf, GermanyDivision of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf, GermanyRecent studies have shown that blueberries may have cardiovascular and cognitive health benefits. In this work, we investigated the profile of plasma and urine (poly)phenol metabolites after acute and daily consumption of wild blueberries for 30 days in 18 healthy men. The inter-individual variability in plasma and urinary polyphenol levels was also investigated. Blood samples were collected at baseline and 2 h post-consumption on day 1 and day 30. Twenty-four-hour urine was also collected on both days. A total of 61 phenolic metabolites were quantified in plasma at baseline, of which 43 increased after acute or chronic consumption of blueberries over one month. Benzoic and catechol derivatives represented more than 80% of the changes in phenolic profile after 2 h consumption on day 1, whereas hippuric and benzoic derivatives were the major compounds that increased at 0 and 2 h on day 30, respectively. The total (poly)phenol urinary excretion remained unchanged after 30 days of wild blueberry intake. The inter-individual variability ranged between 40%–48% in plasma and 47%–54% in urine. Taken together, our results illustrate that blueberry (poly)phenols are absorbed and extensively metabolized by phase II enzymes and by the gut microbiota, leading to a whole array of metabolites that may be responsible for the beneficial effects observed after blueberry consumption.http://www.mdpi.com/1420-3049/21/9/1120(poly)phenolsblueberryacutechronicplasmaurineinter-individual variability |
| spellingShingle | Rodrigo P. Feliciano Geoffrey Istas Christian Heiss Ana Rodriguez-Mateos Plasma and Urinary Phenolic Profiles after Acute and Repetitive Intake of Wild Blueberry Molecules (poly)phenols blueberry acute chronic plasma urine inter-individual variability |
| title | Plasma and Urinary Phenolic Profiles after Acute and Repetitive Intake of Wild Blueberry |
| title_full | Plasma and Urinary Phenolic Profiles after Acute and Repetitive Intake of Wild Blueberry |
| title_fullStr | Plasma and Urinary Phenolic Profiles after Acute and Repetitive Intake of Wild Blueberry |
| title_full_unstemmed | Plasma and Urinary Phenolic Profiles after Acute and Repetitive Intake of Wild Blueberry |
| title_short | Plasma and Urinary Phenolic Profiles after Acute and Repetitive Intake of Wild Blueberry |
| title_sort | plasma and urinary phenolic profiles after acute and repetitive intake of wild blueberry |
| topic | (poly)phenols blueberry acute chronic plasma urine inter-individual variability |
| url | http://www.mdpi.com/1420-3049/21/9/1120 |
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