Thyroid Dysfunction Associated with Depressive Disorder: A Descriptive Cross-Sectional Study Done in a Tertiary Care Center of Eastern Nepal
Background: Depression is one of the most common psychiatric disorders with substantial morbidity and mortality. It is known to be associated with changes in the hypothalamic-pituitary-thyroid axis, thus may be accompanied by subtle thyroid dysfunction. Thus, our study aims to determine the prevalen...
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| Format: | Article |
| Language: | English |
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Nobel Medical College Teaching Hospital
2022-12-01
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| Series: | Journal of Nobel Medical College |
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| Online Access: | https://www.nepjol.info/index.php/JoNMC/article/view/50459 |
| _version_ | 1797971988395851776 |
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| author | Shikha Rizal Mukti Acharya Sunil Regmi Bishal Raj Joshi Sanjay Kumar Jha Dikshya Rana |
| author_facet | Shikha Rizal Mukti Acharya Sunil Regmi Bishal Raj Joshi Sanjay Kumar Jha Dikshya Rana |
| author_sort | Shikha Rizal |
| collection | DOAJ |
| description | Background: Depression is one of the most common psychiatric disorders with substantial morbidity and mortality. It is known to be associated with changes in the hypothalamic-pituitary-thyroid axis, thus may be accompanied by subtle thyroid dysfunction. Thus, our study aims to determine the prevalence and characteristics of thyroid dysfunction in newly diagnosed depressive patients.
Materials and Methods: A prospective descriptive cross sectional study was conducted among 130 patient diagnosed as depression from December 2020 to June 2022 after taking the ethical approval. The patients in the symptomatic phase and above 18 years was recruited in our study. Thyroid profile consisting of free tri-iodothyronine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH) was estimated by chemiluminescence immunoassay in the central laboratory of Nobel Medical College Teaching Hospital.
Results: Out of 130 depressive patients recruited in our study, 44 patients had abnormal thyroid function test showing a prevalence of 33.84%. The most common form was moderate depression which was 39.99% of our study population. The commonest thyroid abnormality was subclinical hypothyroidism (15.38%) followed by overt hypothyroidism (14.61%). Thyroid abnormality was more common among the severe form of depression (46.66%). The comparison of means of fT3, fT4 and TSH between different grades of depression was statistically significant for fT3 (p=0.048) and TSH (p=0.001).
Conclusion: Thus, the most common thyroid function abnormalities in our study include subclinical and overt hypothyroidism, with associated lower level of fT4 and higher level of TSH. |
| first_indexed | 2024-04-11T03:41:21Z |
| format | Article |
| id | doaj.art-aca3aca4e29340c782c4931698c446ac |
| institution | Directory Open Access Journal |
| issn | 2091-2331 2091-234X |
| language | English |
| last_indexed | 2024-04-11T03:41:21Z |
| publishDate | 2022-12-01 |
| publisher | Nobel Medical College Teaching Hospital |
| record_format | Article |
| series | Journal of Nobel Medical College |
| spelling | doaj.art-aca3aca4e29340c782c4931698c446ac2023-01-02T03:41:53ZengNobel Medical College Teaching HospitalJournal of Nobel Medical College2091-23312091-234X2022-12-01112525610.3126/jonmc.v11i2.5045977525Thyroid Dysfunction Associated with Depressive Disorder: A Descriptive Cross-Sectional Study Done in a Tertiary Care Center of Eastern NepalShikha Rizal0https://orcid.org/0000-0002-0710-6233Mukti Acharya1Sunil Regmi2Bishal Raj Joshi3Sanjay Kumar Jha4Dikshya Rana5Department of Biochemistry, Nobel Medical College Teaching Hospital, Biratnagar, NepalDepartment of Psychiatry, Nobel Medical College Teaching Hospital, Biratnagar, NepalDepartment of Urology, Koshi Zonal Hospital, Biratnagar, NepalDepartment of Biochemistry, Nobel Medical College Teaching Hospital, Biratnagar, NepalDepartment of Biochemistry, Nobel Medical College Teaching Hospital, Biratnagar, NepalDepartment of Biochemistry, Janaki Medical College Teaching Hospital, Janakpur, NepalBackground: Depression is one of the most common psychiatric disorders with substantial morbidity and mortality. It is known to be associated with changes in the hypothalamic-pituitary-thyroid axis, thus may be accompanied by subtle thyroid dysfunction. Thus, our study aims to determine the prevalence and characteristics of thyroid dysfunction in newly diagnosed depressive patients. Materials and Methods: A prospective descriptive cross sectional study was conducted among 130 patient diagnosed as depression from December 2020 to June 2022 after taking the ethical approval. The patients in the symptomatic phase and above 18 years was recruited in our study. Thyroid profile consisting of free tri-iodothyronine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH) was estimated by chemiluminescence immunoassay in the central laboratory of Nobel Medical College Teaching Hospital. Results: Out of 130 depressive patients recruited in our study, 44 patients had abnormal thyroid function test showing a prevalence of 33.84%. The most common form was moderate depression which was 39.99% of our study population. The commonest thyroid abnormality was subclinical hypothyroidism (15.38%) followed by overt hypothyroidism (14.61%). Thyroid abnormality was more common among the severe form of depression (46.66%). The comparison of means of fT3, fT4 and TSH between different grades of depression was statistically significant for fT3 (p=0.048) and TSH (p=0.001). Conclusion: Thus, the most common thyroid function abnormalities in our study include subclinical and overt hypothyroidism, with associated lower level of fT4 and higher level of TSH.https://www.nepjol.info/index.php/JoNMC/article/view/50459depressionhyperthyroidismhypothyroidismprevalence |
| spellingShingle | Shikha Rizal Mukti Acharya Sunil Regmi Bishal Raj Joshi Sanjay Kumar Jha Dikshya Rana Thyroid Dysfunction Associated with Depressive Disorder: A Descriptive Cross-Sectional Study Done in a Tertiary Care Center of Eastern Nepal Journal of Nobel Medical College depression hyperthyroidism hypothyroidism prevalence |
| title | Thyroid Dysfunction Associated with Depressive Disorder: A Descriptive Cross-Sectional Study Done in a Tertiary Care Center of Eastern Nepal |
| title_full | Thyroid Dysfunction Associated with Depressive Disorder: A Descriptive Cross-Sectional Study Done in a Tertiary Care Center of Eastern Nepal |
| title_fullStr | Thyroid Dysfunction Associated with Depressive Disorder: A Descriptive Cross-Sectional Study Done in a Tertiary Care Center of Eastern Nepal |
| title_full_unstemmed | Thyroid Dysfunction Associated with Depressive Disorder: A Descriptive Cross-Sectional Study Done in a Tertiary Care Center of Eastern Nepal |
| title_short | Thyroid Dysfunction Associated with Depressive Disorder: A Descriptive Cross-Sectional Study Done in a Tertiary Care Center of Eastern Nepal |
| title_sort | thyroid dysfunction associated with depressive disorder a descriptive cross sectional study done in a tertiary care center of eastern nepal |
| topic | depression hyperthyroidism hypothyroidism prevalence |
| url | https://www.nepjol.info/index.php/JoNMC/article/view/50459 |
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