Ensuring the Safety of Yellow Fever Vaccination in Travelers—The Experience at a Large U.S. Academic Medical Center in Colorado
<b>Background:</b> Yellow fever (YF) virus has the potential to cause fatal outcomes among at-risk individuals visiting endemic areas. Vaccinating travelers who are at risk is necessary to prevent virus-related life-threatening complications. We lack data on the clinical features of pers...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Tropical Medicine and Infectious Disease |
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| Online Access: | https://www.mdpi.com/2414-6366/5/3/125 |
| _version_ | 1827712169862496256 |
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| author | Mehdi Bandali Jonathan Schultz Kimlien Than Donna McGregor Solana Archuleta Sindhu Chadalawada William Mundo Daniel Chastain Carlos Franco-Paredes Elaine Reno Andrés F. Henao-Martínez |
| author_facet | Mehdi Bandali Jonathan Schultz Kimlien Than Donna McGregor Solana Archuleta Sindhu Chadalawada William Mundo Daniel Chastain Carlos Franco-Paredes Elaine Reno Andrés F. Henao-Martínez |
| author_sort | Mehdi Bandali |
| collection | DOAJ |
| description | <b>Background:</b> Yellow fever (YF) virus has the potential to cause fatal outcomes among at-risk individuals visiting endemic areas. Vaccinating travelers who are at risk is necessary to prevent virus-related life-threatening complications. We lack data on the clinical features of persons seeking YF vaccination. We aim to describe the characteristics of a cohort of persons receiving the YF vaccine before travel. <b>Methods:</b> A retrospective analysis of 964 travelers receiving the YF vaccine (Stamaril<sup>®</sup>) from Oct 2016 to Jul 2019 was performed at the University of Colorado Hospital, U.S. Percentages, means, and standard deviations were calculated. A multivariate logistic regression model was built to evaluate the association between receiving YF vaccination less than 10 days before departure and visiting friends and relatives (VFR). <b>Results:</b> The average age of the subjects was 39 ± 18 years with a range of nine months to 83 years. Persons who were 60 years of age and older represented 17%. Women consisted of 52%, and most of the travelers were Caucasians (64%). Travelers reported traveling to Africa (57%) or South America (40%). The primary destinations for travelers overall were Kenya (19%), Uganda (11%), and Tanzania (11%) in Africa; and Peru (14%) and Brazil (13%) in South America. The most common reasons for travel included leisure (44%), VFR (18%), and mission trips (10%). Comorbidities included a history of hematologic disorders (4%), HIV infection (2%), and diabetes mellitus (3%). The average duration between vaccine administration and travel was 43 days. Those VFR were two times more likely to receive the YF vaccination <10 days before departure. <b>Conclusions:</b> Identifying the type of travel, itinerary, and underlying medical conditions allows providers to administer the YF vaccine to travelers safely. There is a need to identify strategies to improve the timing of YF vaccination among VFR travelers. |
| first_indexed | 2024-03-10T18:08:23Z |
| format | Article |
| id | doaj.art-acab1d413b89466882345f60ba947410 |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-03-10T18:08:23Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-acab1d413b89466882345f60ba9474102023-11-20T08:18:31ZengMDPI AGTropical Medicine and Infectious Disease2414-63662020-07-015312510.3390/tropicalmed5030125Ensuring the Safety of Yellow Fever Vaccination in Travelers—The Experience at a Large U.S. Academic Medical Center in ColoradoMehdi Bandali0Jonathan Schultz1Kimlien Than2Donna McGregor3Solana Archuleta4Sindhu Chadalawada5William Mundo6Daniel Chastain7Carlos Franco-Paredes8Elaine Reno9Andrés F. Henao-Martínez10School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADivision of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USASchool of Pharmacy, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADivision of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USASchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USANRI General Hospital, Pradesh 522503, IndiaSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADepartment of Clinical and Administrative Pharmacy, University of Georgia College of Pharmacy, Albany, GA 30901, USADivision of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADepartment of Emergency Medicine, Hospital Infantil de México, Federico Gómez, México City 06720, MexicoDivision of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA<b>Background:</b> Yellow fever (YF) virus has the potential to cause fatal outcomes among at-risk individuals visiting endemic areas. Vaccinating travelers who are at risk is necessary to prevent virus-related life-threatening complications. We lack data on the clinical features of persons seeking YF vaccination. We aim to describe the characteristics of a cohort of persons receiving the YF vaccine before travel. <b>Methods:</b> A retrospective analysis of 964 travelers receiving the YF vaccine (Stamaril<sup>®</sup>) from Oct 2016 to Jul 2019 was performed at the University of Colorado Hospital, U.S. Percentages, means, and standard deviations were calculated. A multivariate logistic regression model was built to evaluate the association between receiving YF vaccination less than 10 days before departure and visiting friends and relatives (VFR). <b>Results:</b> The average age of the subjects was 39 ± 18 years with a range of nine months to 83 years. Persons who were 60 years of age and older represented 17%. Women consisted of 52%, and most of the travelers were Caucasians (64%). Travelers reported traveling to Africa (57%) or South America (40%). The primary destinations for travelers overall were Kenya (19%), Uganda (11%), and Tanzania (11%) in Africa; and Peru (14%) and Brazil (13%) in South America. The most common reasons for travel included leisure (44%), VFR (18%), and mission trips (10%). Comorbidities included a history of hematologic disorders (4%), HIV infection (2%), and diabetes mellitus (3%). The average duration between vaccine administration and travel was 43 days. Those VFR were two times more likely to receive the YF vaccination <10 days before departure. <b>Conclusions:</b> Identifying the type of travel, itinerary, and underlying medical conditions allows providers to administer the YF vaccine to travelers safely. There is a need to identify strategies to improve the timing of YF vaccination among VFR travelers.https://www.mdpi.com/2414-6366/5/3/125yellow fever virusyellow fever vaccinetravel medicinehealth policy |
| spellingShingle | Mehdi Bandali Jonathan Schultz Kimlien Than Donna McGregor Solana Archuleta Sindhu Chadalawada William Mundo Daniel Chastain Carlos Franco-Paredes Elaine Reno Andrés F. Henao-Martínez Ensuring the Safety of Yellow Fever Vaccination in Travelers—The Experience at a Large U.S. Academic Medical Center in Colorado Tropical Medicine and Infectious Disease yellow fever virus yellow fever vaccine travel medicine health policy |
| title | Ensuring the Safety of Yellow Fever Vaccination in Travelers—The Experience at a Large U.S. Academic Medical Center in Colorado |
| title_full | Ensuring the Safety of Yellow Fever Vaccination in Travelers—The Experience at a Large U.S. Academic Medical Center in Colorado |
| title_fullStr | Ensuring the Safety of Yellow Fever Vaccination in Travelers—The Experience at a Large U.S. Academic Medical Center in Colorado |
| title_full_unstemmed | Ensuring the Safety of Yellow Fever Vaccination in Travelers—The Experience at a Large U.S. Academic Medical Center in Colorado |
| title_short | Ensuring the Safety of Yellow Fever Vaccination in Travelers—The Experience at a Large U.S. Academic Medical Center in Colorado |
| title_sort | ensuring the safety of yellow fever vaccination in travelers the experience at a large u s academic medical center in colorado |
| topic | yellow fever virus yellow fever vaccine travel medicine health policy |
| url | https://www.mdpi.com/2414-6366/5/3/125 |
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