The protective role of probiotics in the mitigation of carbon tetrachloride (CCl4) induced hepatotoxicity
Carbon tetrachloride (CCl4) is one of the traditional hepatotoxicants. Chronic liver damage can result from long-term CCl4 treatment, which is also a well-known model for producing hepatotoxicity. After entering the body, CCl4 is activated by hepatic cytochrome P450 and produces unstable trichlorome...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Food Chemistry Advances |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772753X23000254 |
| _version_ | 1797796071882096640 |
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| author | Tarun Kumar Dua Gouhar Jahan Ashraf Sangita Palai Tania Baishya Gouranga Nandi Ranabir Sahu Paramita Paul |
| author_facet | Tarun Kumar Dua Gouhar Jahan Ashraf Sangita Palai Tania Baishya Gouranga Nandi Ranabir Sahu Paramita Paul |
| author_sort | Tarun Kumar Dua |
| collection | DOAJ |
| description | Carbon tetrachloride (CCl4) is one of the traditional hepatotoxicants. Chronic liver damage can result from long-term CCl4 treatment, which is also a well-known model for producing hepatotoxicity. After entering the body, CCl4 is activated by hepatic cytochrome P450 and produces unstable trichloromethyl and trichloromethyl peroxyl radicals. These two types of free radicals attack polyunsaturated fatty acids in biofilm phospholipids and cause lipid peroxidation events, which might finally result in hepatotoxicity. It has recently been investigated that probiotic microorganisms have been found to reduce the liver damage caused by experimentally induced CCl4 exposure. The current review aims to compile experimental research on probiotics' ability to protect the liver against CCl4-induced hepatotoxicity. Nine different types of probiotic microbes were found to significantly protect against CCl4-induced hepatotoxicity in experimental preclinical investigations. According to the findings of the preclinical research, probiotics may be able to lessen the effects of CCl4-induced hepatotoxicity. |
| first_indexed | 2024-03-13T03:27:37Z |
| format | Article |
| id | doaj.art-acab826f380a468594c1eba2107c2105 |
| institution | Directory Open Access Journal |
| issn | 2772-753X |
| language | English |
| last_indexed | 2024-03-13T03:27:37Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Food Chemistry Advances |
| spelling | doaj.art-acab826f380a468594c1eba2107c21052023-06-25T04:44:37ZengElsevierFood Chemistry Advances2772-753X2023-10-012100205The protective role of probiotics in the mitigation of carbon tetrachloride (CCl4) induced hepatotoxicityTarun Kumar Dua0Gouhar Jahan Ashraf1Sangita Palai2Tania Baishya3Gouranga Nandi4Ranabir Sahu5Paramita Paul6Department of Pharmaceutical Technology, University of North Bengal, Raja Rammohunpur, P.O.- NBU, District- Darjeeling, 734013, West Bengal, India; Corresponding author at: Department of Pharmaceutical Technology, University of North Bengal, Raja Rammohunpur, P.O.- NBU, District- Darjeeling, 734013, West Bengal, India.Department of Pharmaceutical Technology, University of North Bengal, Raja Rammohunpur, P.O.- NBU, District- Darjeeling, 734013, West Bengal, IndiaDepartment of Pharmaceutical Technology, University of North Bengal, Raja Rammohunpur, P.O.- NBU, District- Darjeeling, 734013, West Bengal, India; Eminent College of Pharmaceutical Technology, Moshpukur, Barbaria, P.O. Jagannathpur, Kolkata, 700126, West Bengal, IndiaDepartment of Tea Science, University of North Bengal, Raja Rammohunpur, P.O.- NBU, District- Darjeeling, 734013, West Bengal, IndiaDepartment of Pharmaceutical Technology, University of North Bengal, Raja Rammohunpur, P.O.- NBU, District- Darjeeling, 734013, West Bengal, IndiaDepartment of Pharmaceutical Technology, University of North Bengal, Raja Rammohunpur, P.O.- NBU, District- Darjeeling, 734013, West Bengal, IndiaDepartment of Pharmaceutical Technology, University of North Bengal, Raja Rammohunpur, P.O.- NBU, District- Darjeeling, 734013, West Bengal, IndiaCarbon tetrachloride (CCl4) is one of the traditional hepatotoxicants. Chronic liver damage can result from long-term CCl4 treatment, which is also a well-known model for producing hepatotoxicity. After entering the body, CCl4 is activated by hepatic cytochrome P450 and produces unstable trichloromethyl and trichloromethyl peroxyl radicals. These two types of free radicals attack polyunsaturated fatty acids in biofilm phospholipids and cause lipid peroxidation events, which might finally result in hepatotoxicity. It has recently been investigated that probiotic microorganisms have been found to reduce the liver damage caused by experimentally induced CCl4 exposure. The current review aims to compile experimental research on probiotics' ability to protect the liver against CCl4-induced hepatotoxicity. Nine different types of probiotic microbes were found to significantly protect against CCl4-induced hepatotoxicity in experimental preclinical investigations. According to the findings of the preclinical research, probiotics may be able to lessen the effects of CCl4-induced hepatotoxicity.http://www.sciencedirect.com/science/article/pii/S2772753X23000254Carbon tetrachlorideHepatoprotective effectHepatotoxicityProbiotics |
| spellingShingle | Tarun Kumar Dua Gouhar Jahan Ashraf Sangita Palai Tania Baishya Gouranga Nandi Ranabir Sahu Paramita Paul The protective role of probiotics in the mitigation of carbon tetrachloride (CCl4) induced hepatotoxicity Food Chemistry Advances Carbon tetrachloride Hepatoprotective effect Hepatotoxicity Probiotics |
| title | The protective role of probiotics in the mitigation of carbon tetrachloride (CCl4) induced hepatotoxicity |
| title_full | The protective role of probiotics in the mitigation of carbon tetrachloride (CCl4) induced hepatotoxicity |
| title_fullStr | The protective role of probiotics in the mitigation of carbon tetrachloride (CCl4) induced hepatotoxicity |
| title_full_unstemmed | The protective role of probiotics in the mitigation of carbon tetrachloride (CCl4) induced hepatotoxicity |
| title_short | The protective role of probiotics in the mitigation of carbon tetrachloride (CCl4) induced hepatotoxicity |
| title_sort | protective role of probiotics in the mitigation of carbon tetrachloride ccl4 induced hepatotoxicity |
| topic | Carbon tetrachloride Hepatoprotective effect Hepatotoxicity Probiotics |
| url | http://www.sciencedirect.com/science/article/pii/S2772753X23000254 |
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