A Randomized Study Assessing the Effect of Diet in Cats with Hypertrophic Cardiomyopathy
Background Diet might influence progression of hypertrophic cardiomyopathy (HCM). Objective To investigate whether diet composition could alter clinical, biochemical, or echocardiographic variables in cats with HCM. Animals Twenty‐nine cats with HCM (International Small Animal Cardiac Health Council...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-05-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.12352 |
| _version_ | 1811340499473137664 |
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| author | L.M. Freeman J.E. Rush S.M. Cunningham B.J. Bulmer |
| author_facet | L.M. Freeman J.E. Rush S.M. Cunningham B.J. Bulmer |
| author_sort | L.M. Freeman |
| collection | DOAJ |
| description | Background Diet might influence progression of hypertrophic cardiomyopathy (HCM). Objective To investigate whether diet composition could alter clinical, biochemical, or echocardiographic variables in cats with HCM. Animals Twenty‐nine cats with HCM (International Small Animal Cardiac Health Council stage 1b) examined at a university teaching hospital. Methods Randomized, placebo‐controlled trial. After physical examination, echocardiogram, and blood collection, cats were randomized to 1 of 3 diets, which varied in carbohydrate and fat content and ingredients. Measurements were repeated after 6 months. Results There were no significant differences among the 3 groups at baseline. After 6 months, there were no significant changes in the primary endpoints, left ventricular free wall (Group A, P = .760; Group B, P = .475; Group C, P = .066) or interventricular septal thickness in diastole (Group A, P = .528; Group B, P = .221; Group C, P = .097). Group A had significant increases in BUN (P = .008) and cholesterol (P = .021), while Group B had significant increases in BUN (P = .008), cholesterol (P = .007), and triglycerides (P = .005), and significant decreases in NT‐proBNP (P = .013) and hs‐troponin I (P = .043). Group C had significant decreases in body weight (P = .021), left atrial dimension (P = .035), interventricular septal thickness in systole (P = .038), and liver enzymes (P = .034–.038). Conclusions and Clinical Importance These data suggest that diet might influence some clinical, biochemical, and echocardiographic variables in cats with HCM. |
| first_indexed | 2024-04-13T18:41:48Z |
| format | Article |
| id | doaj.art-acacc4a3641f43a5bd65a23a71cf7e33 |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-04-13T18:41:48Z |
| publishDate | 2014-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-acacc4a3641f43a5bd65a23a71cf7e332022-12-22T02:34:41ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762014-05-0128384785610.1111/jvim.12352A Randomized Study Assessing the Effect of Diet in Cats with Hypertrophic CardiomyopathyL.M. Freeman0J.E. Rush1S.M. Cunningham2B.J. Bulmer3Department of Clinical Sciences Tufts Cummings School of Veterinary Medicine North Grafton MADepartment of Clinical Sciences Tufts Cummings School of Veterinary Medicine North Grafton MADepartment of Clinical Sciences Tufts Cummings School of Veterinary Medicine North Grafton MADepartment of Clinical Sciences Tufts Cummings School of Veterinary Medicine North Grafton MABackground Diet might influence progression of hypertrophic cardiomyopathy (HCM). Objective To investigate whether diet composition could alter clinical, biochemical, or echocardiographic variables in cats with HCM. Animals Twenty‐nine cats with HCM (International Small Animal Cardiac Health Council stage 1b) examined at a university teaching hospital. Methods Randomized, placebo‐controlled trial. After physical examination, echocardiogram, and blood collection, cats were randomized to 1 of 3 diets, which varied in carbohydrate and fat content and ingredients. Measurements were repeated after 6 months. Results There were no significant differences among the 3 groups at baseline. After 6 months, there were no significant changes in the primary endpoints, left ventricular free wall (Group A, P = .760; Group B, P = .475; Group C, P = .066) or interventricular septal thickness in diastole (Group A, P = .528; Group B, P = .221; Group C, P = .097). Group A had significant increases in BUN (P = .008) and cholesterol (P = .021), while Group B had significant increases in BUN (P = .008), cholesterol (P = .007), and triglycerides (P = .005), and significant decreases in NT‐proBNP (P = .013) and hs‐troponin I (P = .043). Group C had significant decreases in body weight (P = .021), left atrial dimension (P = .035), interventricular septal thickness in systole (P = .038), and liver enzymes (P = .034–.038). Conclusions and Clinical Importance These data suggest that diet might influence some clinical, biochemical, and echocardiographic variables in cats with HCM.https://doi.org/10.1111/jvim.12352CardiomyopathyCongestive heart failureNutrition |
| spellingShingle | L.M. Freeman J.E. Rush S.M. Cunningham B.J. Bulmer A Randomized Study Assessing the Effect of Diet in Cats with Hypertrophic Cardiomyopathy Journal of Veterinary Internal Medicine Cardiomyopathy Congestive heart failure Nutrition |
| title | A Randomized Study Assessing the Effect of Diet in Cats with Hypertrophic Cardiomyopathy |
| title_full | A Randomized Study Assessing the Effect of Diet in Cats with Hypertrophic Cardiomyopathy |
| title_fullStr | A Randomized Study Assessing the Effect of Diet in Cats with Hypertrophic Cardiomyopathy |
| title_full_unstemmed | A Randomized Study Assessing the Effect of Diet in Cats with Hypertrophic Cardiomyopathy |
| title_short | A Randomized Study Assessing the Effect of Diet in Cats with Hypertrophic Cardiomyopathy |
| title_sort | randomized study assessing the effect of diet in cats with hypertrophic cardiomyopathy |
| topic | Cardiomyopathy Congestive heart failure Nutrition |
| url | https://doi.org/10.1111/jvim.12352 |
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