Vaginal metastasis of lung cancer: A case report
Lung adenosquamous carcinoma (ASC) is a rare biphasic malignant tumor with squamous cell carcinoma (SCC) and adenocarcinoma (AC) components. ASC is reported to be aggressive; the most common metastatic sites are the regional lymph nodes and surrounding areas.A 46-year-old woman was referred to the e...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Case Reports in Women's Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214911223000607 |
| _version_ | 1797647638414229504 |
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| author | Federica Savasta Michele Giana Alessandro Libretti Silvia Genestroni Daniela Surico Valentino Remorgida |
| author_facet | Federica Savasta Michele Giana Alessandro Libretti Silvia Genestroni Daniela Surico Valentino Remorgida |
| author_sort | Federica Savasta |
| collection | DOAJ |
| description | Lung adenosquamous carcinoma (ASC) is a rare biphasic malignant tumor with squamous cell carcinoma (SCC) and adenocarcinoma (AC) components. ASC is reported to be aggressive; the most common metastatic sites are the regional lymph nodes and surrounding areas.A 46-year-old woman was referred to the emergency department with a persistent dry cough. She underwent fibro-bronchoscopy and was diagnosed with an adenosquamous lung carcinoma. Other than pulmonary and lymphatic findings, a total-body computed tomography (CT) examination highlighted a hypodense formation, of about 9 mm, with a cystic appearance, at the level of the vaginal region. A biopsy performed in the posterior vaginal wall highlighted a vaginal wall flap with subepithelial localization of neoplasia, compatible with the pulmonary ASC. Oncologists took charge of the case and the patient commenced medical therapy with entrectinib. Four months later, she developed dyspnea, and high-resolution CT highlighted an increase in the pathological tissue causing bronchial occlusion. The patient underwent endobronchial stent placement and thereafter restarted therapy with entrectinib, previously stopped because of the new symptoms, and was closely monitored.Apparently only one case of vaginal metastasis from pulmonary tumor has been previously reported, and this is the first report of vaginal metastasis from ASC. Although extremely rare, the presence of such metastasis should be considered in women with suspected vaginal neoformations. |
| first_indexed | 2024-03-11T15:19:24Z |
| format | Article |
| id | doaj.art-acadcee14f3143df933c12db4cde75b6 |
| institution | Directory Open Access Journal |
| issn | 2214-9112 |
| language | English |
| last_indexed | 2024-03-11T15:19:24Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Case Reports in Women's Health |
| spelling | doaj.art-acadcee14f3143df933c12db4cde75b62023-10-29T04:19:50ZengElsevierCase Reports in Women's Health2214-91122023-09-0139e00536Vaginal metastasis of lung cancer: A case reportFederica Savasta0Michele Giana1Alessandro Libretti2Silvia Genestroni3Daniela Surico4Valentino Remorgida5Department of Gynaecology and Obstetrics, University of Piemonte Orientale, Ospedale Maggiore della Carità, corso Mazzini 19, Novara, Italy; Corresponding author at: Department of Gynaecology and Obstetrics, University of Piemonte Orientale, Ospedale Maggiore della Carità, corso Mazzini 19, Novara 28100, Italy.Department of Gynaecology and Obstetrics, University of Piemonte Orientale, Ospedale Maggiore della Carità, corso Mazzini 19, Novara, ItalyDepartment of Gynaecology and Obstetrics, University of Piemonte Orientale, Ospedale Maggiore della Carità, corso Mazzini 19, Novara, ItalyDepartment of Oncology, University of Piemonte Orientale, Ospedale Maggiore della Carità, corso Mazzini 19, Novara, ItalyDepartment of Gynaecology and Obstetrics, University of Piemonte Orientale, Ospedale Maggiore della Carità, corso Mazzini 19, Novara, ItalyDepartment of Gynaecology and Obstetrics, University of Piemonte Orientale, Ospedale Maggiore della Carità, corso Mazzini 19, Novara, ItalyLung adenosquamous carcinoma (ASC) is a rare biphasic malignant tumor with squamous cell carcinoma (SCC) and adenocarcinoma (AC) components. ASC is reported to be aggressive; the most common metastatic sites are the regional lymph nodes and surrounding areas.A 46-year-old woman was referred to the emergency department with a persistent dry cough. She underwent fibro-bronchoscopy and was diagnosed with an adenosquamous lung carcinoma. Other than pulmonary and lymphatic findings, a total-body computed tomography (CT) examination highlighted a hypodense formation, of about 9 mm, with a cystic appearance, at the level of the vaginal region. A biopsy performed in the posterior vaginal wall highlighted a vaginal wall flap with subepithelial localization of neoplasia, compatible with the pulmonary ASC. Oncologists took charge of the case and the patient commenced medical therapy with entrectinib. Four months later, she developed dyspnea, and high-resolution CT highlighted an increase in the pathological tissue causing bronchial occlusion. The patient underwent endobronchial stent placement and thereafter restarted therapy with entrectinib, previously stopped because of the new symptoms, and was closely monitored.Apparently only one case of vaginal metastasis from pulmonary tumor has been previously reported, and this is the first report of vaginal metastasis from ASC. Although extremely rare, the presence of such metastasis should be considered in women with suspected vaginal neoformations.http://www.sciencedirect.com/science/article/pii/S2214911223000607Vaginal metastasisAdenosquamous carcinomaLung cancerCase report |
| spellingShingle | Federica Savasta Michele Giana Alessandro Libretti Silvia Genestroni Daniela Surico Valentino Remorgida Vaginal metastasis of lung cancer: A case report Case Reports in Women's Health Vaginal metastasis Adenosquamous carcinoma Lung cancer Case report |
| title | Vaginal metastasis of lung cancer: A case report |
| title_full | Vaginal metastasis of lung cancer: A case report |
| title_fullStr | Vaginal metastasis of lung cancer: A case report |
| title_full_unstemmed | Vaginal metastasis of lung cancer: A case report |
| title_short | Vaginal metastasis of lung cancer: A case report |
| title_sort | vaginal metastasis of lung cancer a case report |
| topic | Vaginal metastasis Adenosquamous carcinoma Lung cancer Case report |
| url | http://www.sciencedirect.com/science/article/pii/S2214911223000607 |
| work_keys_str_mv | AT federicasavasta vaginalmetastasisoflungcanceracasereport AT michelegiana vaginalmetastasisoflungcanceracasereport AT alessandrolibretti vaginalmetastasisoflungcanceracasereport AT silviagenestroni vaginalmetastasisoflungcanceracasereport AT danielasurico vaginalmetastasisoflungcanceracasereport AT valentinoremorgida vaginalmetastasisoflungcanceracasereport |