Recurrent primary mediastinal giant cell tumor of soft tissue with radiological findings: a rare case report and literature review
Abstract Background Giant cell tumor of soft tissue (GCT-ST), which histologically resembles GCT of bone, is a rare tumor. Usually, it is located in the lower extremities and trunk. GCT-ST, occurring in mediastinum, is extremely rare. Case presentation We encountered an 18-year-old Chinese woman who...
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| Format: | Article |
| Language: | English |
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BMC
2017-07-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | http://link.springer.com/article/10.1186/s12957-017-1205-5 |
| _version_ | 1829137646447755264 |
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| author | Qiongjie Hu Jian Peng Liming Xia |
| author_facet | Qiongjie Hu Jian Peng Liming Xia |
| author_sort | Qiongjie Hu |
| collection | DOAJ |
| description | Abstract Background Giant cell tumor of soft tissue (GCT-ST), which histologically resembles GCT of bone, is a rare tumor. Usually, it is located in the lower extremities and trunk. GCT-ST, occurring in mediastinum, is extremely rare. Case presentation We encountered an 18-year-old Chinese woman who had mild dull pain on the left side of back. The following chest computed tomography (CT) showed a heterogeneous mass deeply situated in the posterior mediastinum with compression of the lung and invasion of the adjacent rib. On magnetic resonance imaging (MRI), the tumor exhibited predominantly slight hyperintensity on T2-weighted images and intensely heterogeneous enhancement on contrast-enhanced T1-weighted images. The whole body bone scan showed a mildly increased radiotracer uptake in the proximal portion of the left fifth rib, suggestive of local infiltration by the tumor. Surgical resection of the tumor was performed; subsequently, the tumor was histopathologically proved as GCT-ST. Three months after the operation, the patient developed a local recurrence. A brief discussion about the radiological findings, histopathological features, clinical behavior, and a detailed review of the relevant literature are presented. Conclusions To the best of our knowledge, this is the first case about recurrent primary mediastinal GCT-ST, moreover, this is the first report to introduce the MRI findings of primary mediastinal GCT-ST. The present case highlights the ubiquitous distribution of soft tissue giant cell tumor and the importance of considering this tumor in the differential diagnosis of posterior mediastinal neoplasms. Also, a long-term follow-up is required to properly assess the malignant potential of this tumor. |
| first_indexed | 2024-12-14T19:01:58Z |
| format | Article |
| id | doaj.art-acaf9f4783f54c0ea7a9e7fa6096290f |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-14T19:01:58Z |
| publishDate | 2017-07-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-acaf9f4783f54c0ea7a9e7fa6096290f2022-12-21T22:50:56ZengBMCWorld Journal of Surgical Oncology1477-78192017-07-011511610.1186/s12957-017-1205-5Recurrent primary mediastinal giant cell tumor of soft tissue with radiological findings: a rare case report and literature reviewQiongjie Hu0Jian Peng1Liming Xia2Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Background Giant cell tumor of soft tissue (GCT-ST), which histologically resembles GCT of bone, is a rare tumor. Usually, it is located in the lower extremities and trunk. GCT-ST, occurring in mediastinum, is extremely rare. Case presentation We encountered an 18-year-old Chinese woman who had mild dull pain on the left side of back. The following chest computed tomography (CT) showed a heterogeneous mass deeply situated in the posterior mediastinum with compression of the lung and invasion of the adjacent rib. On magnetic resonance imaging (MRI), the tumor exhibited predominantly slight hyperintensity on T2-weighted images and intensely heterogeneous enhancement on contrast-enhanced T1-weighted images. The whole body bone scan showed a mildly increased radiotracer uptake in the proximal portion of the left fifth rib, suggestive of local infiltration by the tumor. Surgical resection of the tumor was performed; subsequently, the tumor was histopathologically proved as GCT-ST. Three months after the operation, the patient developed a local recurrence. A brief discussion about the radiological findings, histopathological features, clinical behavior, and a detailed review of the relevant literature are presented. Conclusions To the best of our knowledge, this is the first case about recurrent primary mediastinal GCT-ST, moreover, this is the first report to introduce the MRI findings of primary mediastinal GCT-ST. The present case highlights the ubiquitous distribution of soft tissue giant cell tumor and the importance of considering this tumor in the differential diagnosis of posterior mediastinal neoplasms. Also, a long-term follow-up is required to properly assess the malignant potential of this tumor.http://link.springer.com/article/10.1186/s12957-017-1205-5Giant cell tumorSoft tissueMediastinumRecurrenceImagingMagnetic resonance imaging |
| spellingShingle | Qiongjie Hu Jian Peng Liming Xia Recurrent primary mediastinal giant cell tumor of soft tissue with radiological findings: a rare case report and literature review World Journal of Surgical Oncology Giant cell tumor Soft tissue Mediastinum Recurrence Imaging Magnetic resonance imaging |
| title | Recurrent primary mediastinal giant cell tumor of soft tissue with radiological findings: a rare case report and literature review |
| title_full | Recurrent primary mediastinal giant cell tumor of soft tissue with radiological findings: a rare case report and literature review |
| title_fullStr | Recurrent primary mediastinal giant cell tumor of soft tissue with radiological findings: a rare case report and literature review |
| title_full_unstemmed | Recurrent primary mediastinal giant cell tumor of soft tissue with radiological findings: a rare case report and literature review |
| title_short | Recurrent primary mediastinal giant cell tumor of soft tissue with radiological findings: a rare case report and literature review |
| title_sort | recurrent primary mediastinal giant cell tumor of soft tissue with radiological findings a rare case report and literature review |
| topic | Giant cell tumor Soft tissue Mediastinum Recurrence Imaging Magnetic resonance imaging |
| url | http://link.springer.com/article/10.1186/s12957-017-1205-5 |
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