Could admission level of uric acid predict total diuretic dose in acute heart failure?
Abstract Background Recent studies have shown that increases in serum UA levels are associated with adverse clinical outcomes in patients with chronic heart failure (CHF); the aim of this study was to determine the relationship between serum uric acid and total diuretic dose received during hospital...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-023-03687-w |
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| author | Maryam Chenaghlou Fatemeh Abedi mahzoon Sina Hamzehzadeh Ali Norouzi Hadi Sahrai Nasibeh Mohammadi Negin Khadem haghighi Mirsaeed Abdollahi Mohammadreza Taban Sadeghi Erfan Banisefid |
| author_facet | Maryam Chenaghlou Fatemeh Abedi mahzoon Sina Hamzehzadeh Ali Norouzi Hadi Sahrai Nasibeh Mohammadi Negin Khadem haghighi Mirsaeed Abdollahi Mohammadreza Taban Sadeghi Erfan Banisefid |
| author_sort | Maryam Chenaghlou |
| collection | DOAJ |
| description | Abstract Background Recent studies have shown that increases in serum UA levels are associated with adverse clinical outcomes in patients with chronic heart failure (CHF); the aim of this study was to determine the relationship between serum uric acid and total diuretic dose received during hospitalization in hospitalized patients with acute exacerbation of heart failure. The main purpose of this study is to determine the role of uric acid as a biomarker that can be a substitute for pro-BNP in clinical evaluation and the need for diuretics in hospitalized patients with acute heart failure. Methods After approving the plan in the Research Council of the Heart Department and obtaining an ethical code from the Regional Committee on Research Ethics (Human Subjects Studies), the researcher referred to the archives of our center, the case of 100 patients diagnosed with acute heart failure. Cardiac patients were selected, and the information required for the study was collected using a pre-prepared data collection form, and the information was entered into SPSS software after categorization and appropriate analysis and statistical tests were performed on it. Were performed and in all statistical tests the statistical significance level was considered 0.05: Results 100 patients with acute heart failure were included in this study with a mean age of 63.43 ± 14.78 years. 66% of them were men. The mean dose of furosemide in these patients was 680.92 ± 377.47 mg and the mean serum uric acid level in these patients was 8.55 ± 2.50 mg / dL. In the study of the relationship between the variables, there was a significant relationship between the dose of furosemide received with the serum level of serum uric acid (P = 0.017, r = 0.248 and P = 0.009, r = -0.267, respectively). There is also a significant relationship between serum uric acid level and patient mortality (P = 0.013, r = 0.247). However this relationship lost its significance after multivariate analysis. Conclusion There is a significant relationship between serum uric acid level and diuretic use. However, in-hospital mortality is not related to uric acid levels at admission. |
| first_indexed | 2024-03-08T16:24:32Z |
| format | Article |
| id | doaj.art-acb100b63504445fb01147b66fdaaee6 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-03-08T16:24:32Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-acb100b63504445fb01147b66fdaaee62024-01-07T12:09:59ZengBMCBMC Cardiovascular Disorders1471-22612024-01-0124111010.1186/s12872-023-03687-wCould admission level of uric acid predict total diuretic dose in acute heart failure?Maryam Chenaghlou0Fatemeh Abedi mahzoon1Sina Hamzehzadeh2Ali Norouzi3Hadi Sahrai4Nasibeh Mohammadi5Negin Khadem haghighi6Mirsaeed Abdollahi7Mohammadreza Taban Sadeghi8Erfan Banisefid9Cardiovascular research center, Tabriz University of Medical SciencesStudent research committee, Tabriz University of Medical SciencesStudent research committee, Tabriz University of Medical SciencesStudent research committee, Tabriz University of Medical SciencesStudent research committee, Tabriz University of Medical SciencesFaculty of medicine, Zanjan University of Medical SciencesStudent research committee, Tabriz University of Medical SciencesStudent research committee, Tabriz University of Medical SciencesCardiovascular research center, Tabriz University of Medical SciencesStudent research committee, Tabriz University of Medical SciencesAbstract Background Recent studies have shown that increases in serum UA levels are associated with adverse clinical outcomes in patients with chronic heart failure (CHF); the aim of this study was to determine the relationship between serum uric acid and total diuretic dose received during hospitalization in hospitalized patients with acute exacerbation of heart failure. The main purpose of this study is to determine the role of uric acid as a biomarker that can be a substitute for pro-BNP in clinical evaluation and the need for diuretics in hospitalized patients with acute heart failure. Methods After approving the plan in the Research Council of the Heart Department and obtaining an ethical code from the Regional Committee on Research Ethics (Human Subjects Studies), the researcher referred to the archives of our center, the case of 100 patients diagnosed with acute heart failure. Cardiac patients were selected, and the information required for the study was collected using a pre-prepared data collection form, and the information was entered into SPSS software after categorization and appropriate analysis and statistical tests were performed on it. Were performed and in all statistical tests the statistical significance level was considered 0.05: Results 100 patients with acute heart failure were included in this study with a mean age of 63.43 ± 14.78 years. 66% of them were men. The mean dose of furosemide in these patients was 680.92 ± 377.47 mg and the mean serum uric acid level in these patients was 8.55 ± 2.50 mg / dL. In the study of the relationship between the variables, there was a significant relationship between the dose of furosemide received with the serum level of serum uric acid (P = 0.017, r = 0.248 and P = 0.009, r = -0.267, respectively). There is also a significant relationship between serum uric acid level and patient mortality (P = 0.013, r = 0.247). However this relationship lost its significance after multivariate analysis. Conclusion There is a significant relationship between serum uric acid level and diuretic use. However, in-hospital mortality is not related to uric acid levels at admission.https://doi.org/10.1186/s12872-023-03687-wHeart FailureHyperuricemiaDiuretic dosage |
| spellingShingle | Maryam Chenaghlou Fatemeh Abedi mahzoon Sina Hamzehzadeh Ali Norouzi Hadi Sahrai Nasibeh Mohammadi Negin Khadem haghighi Mirsaeed Abdollahi Mohammadreza Taban Sadeghi Erfan Banisefid Could admission level of uric acid predict total diuretic dose in acute heart failure? BMC Cardiovascular Disorders Heart Failure Hyperuricemia Diuretic dosage |
| title | Could admission level of uric acid predict total diuretic dose in acute heart failure? |
| title_full | Could admission level of uric acid predict total diuretic dose in acute heart failure? |
| title_fullStr | Could admission level of uric acid predict total diuretic dose in acute heart failure? |
| title_full_unstemmed | Could admission level of uric acid predict total diuretic dose in acute heart failure? |
| title_short | Could admission level of uric acid predict total diuretic dose in acute heart failure? |
| title_sort | could admission level of uric acid predict total diuretic dose in acute heart failure |
| topic | Heart Failure Hyperuricemia Diuretic dosage |
| url | https://doi.org/10.1186/s12872-023-03687-w |
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