Comparison of the Effects of Crocus Sativus and Mefenamic Acid on Primary Dysmenorrhea
Background: In previous studies, extract of 3 herbs, celery, fenugreek and saffron was effective on primary dysmenorrhea. However, the health effects of saffron alone on primary dysmenorrhea have not been yet studied. The aim of this double blind, single center clinical trial is to examine the effec...
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| Format: | Article |
| Language: | English |
| Published: |
Research Center for Rational Use of Drugs (RCRUD)
2018-02-01
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| Series: | Journal of Pharmaceutical Care |
| Subjects: | |
| Online Access: | https://jpc.tums.ac.ir/index.php/jpc/article/view/170 |
| _version_ | 1818145010301796352 |
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| author | Parastoo Azimi Ramin Abrishami |
| author_facet | Parastoo Azimi Ramin Abrishami |
| author_sort | Parastoo Azimi |
| collection | DOAJ |
| description | Background: In previous studies, extract of 3 herbs, celery, fenugreek and saffron was effective on primary dysmenorrhea. However, the health effects of saffron alone on primary dysmenorrhea have not been yet studied. The aim of this double blind, single center clinical trial is to examine the effects of saffron on primary dysmenorrhea pain in women aged 18-27 years old.
Methods: One hundred eighty patients were randomly divided into three groups. Group 1 received saffron capsules three times per day for three days of menstrual period for three consecutive menstrual cycles. Group 2 received mefenamic acid, and group 3 has received identical placebo. Visual Analogue Scale (VAS) has been recorded at baseline and after each menstrual period.
Results: In saffron group VAS was reduced from 6.8 to 3.6, 3.4, and 3 in 3 consecutive months. This effect was significantly greater than mefenamic acid and placebo (P:0.0001).
Conclusions: It was found that the effect of saffron in reducing pain is more than mefenamic acid and far more than placebo. |
| first_indexed | 2024-12-11T11:56:39Z |
| format | Article |
| id | doaj.art-acb1588bbdf646aa9483072bc0f38293 |
| institution | Directory Open Access Journal |
| issn | 2322-4630 2322-4509 |
| language | English |
| last_indexed | 2024-12-11T11:56:39Z |
| publishDate | 2018-02-01 |
| publisher | Research Center for Rational Use of Drugs (RCRUD) |
| record_format | Article |
| series | Journal of Pharmaceutical Care |
| spelling | doaj.art-acb1588bbdf646aa9483072bc0f382932022-12-22T01:08:11ZengResearch Center for Rational Use of Drugs (RCRUD)Journal of Pharmaceutical Care2322-46302322-45092018-02-0143-4104Comparison of the Effects of Crocus Sativus and Mefenamic Acid on Primary DysmenorrheaParastoo Azimi0Ramin Abrishami1Department of Clinical Pharmacy, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran -Iran (IAUPS)Department of Clinical Pharmacy, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran -Iran (IAUPS)Background: In previous studies, extract of 3 herbs, celery, fenugreek and saffron was effective on primary dysmenorrhea. However, the health effects of saffron alone on primary dysmenorrhea have not been yet studied. The aim of this double blind, single center clinical trial is to examine the effects of saffron on primary dysmenorrhea pain in women aged 18-27 years old. Methods: One hundred eighty patients were randomly divided into three groups. Group 1 received saffron capsules three times per day for three days of menstrual period for three consecutive menstrual cycles. Group 2 received mefenamic acid, and group 3 has received identical placebo. Visual Analogue Scale (VAS) has been recorded at baseline and after each menstrual period. Results: In saffron group VAS was reduced from 6.8 to 3.6, 3.4, and 3 in 3 consecutive months. This effect was significantly greater than mefenamic acid and placebo (P:0.0001). Conclusions: It was found that the effect of saffron in reducing pain is more than mefenamic acid and far more than placebo.https://jpc.tums.ac.ir/index.php/jpc/article/view/170Crocus SativusMefenamic AcidDysmenorrheaVisual Analog Scale |
| spellingShingle | Parastoo Azimi Ramin Abrishami Comparison of the Effects of Crocus Sativus and Mefenamic Acid on Primary Dysmenorrhea Journal of Pharmaceutical Care Crocus Sativus Mefenamic Acid Dysmenorrhea Visual Analog Scale |
| title | Comparison of the Effects of Crocus Sativus and Mefenamic Acid on Primary Dysmenorrhea |
| title_full | Comparison of the Effects of Crocus Sativus and Mefenamic Acid on Primary Dysmenorrhea |
| title_fullStr | Comparison of the Effects of Crocus Sativus and Mefenamic Acid on Primary Dysmenorrhea |
| title_full_unstemmed | Comparison of the Effects of Crocus Sativus and Mefenamic Acid on Primary Dysmenorrhea |
| title_short | Comparison of the Effects of Crocus Sativus and Mefenamic Acid on Primary Dysmenorrhea |
| title_sort | comparison of the effects of crocus sativus and mefenamic acid on primary dysmenorrhea |
| topic | Crocus Sativus Mefenamic Acid Dysmenorrhea Visual Analog Scale |
| url | https://jpc.tums.ac.ir/index.php/jpc/article/view/170 |
| work_keys_str_mv | AT parastooazimi comparisonoftheeffectsofcrocussativusandmefenamicacidonprimarydysmenorrhea AT raminabrishami comparisonoftheeffectsofcrocussativusandmefenamicacidonprimarydysmenorrhea |