Physiological and Pathophysiological Roles of Mitochondrial Na<sup>+</sup>-Ca<sup>2+</sup> Exchanger, NCLX, in Hearts
It has been over 10 years since <i>SLC24A6/SLC8B1</i>, coding the Na<sup>+</sup>/Ca<sup>2+</sup>/Li<sup>+</sup> exchanger (NCLX), was identified as the gene responsible for mitochondrial Na<sup>+</sup>-Ca<sup>2+</sup> exchange,...
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| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/12/1876 |
| _version_ | 1827673960187166720 |
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| author | Ayako Takeuchi Satoshi Matsuoka |
| author_facet | Ayako Takeuchi Satoshi Matsuoka |
| author_sort | Ayako Takeuchi |
| collection | DOAJ |
| description | It has been over 10 years since <i>SLC24A6/SLC8B1</i>, coding the Na<sup>+</sup>/Ca<sup>2+</sup>/Li<sup>+</sup> exchanger (NCLX), was identified as the gene responsible for mitochondrial Na<sup>+</sup>-Ca<sup>2+</sup> exchange, a major Ca<sup>2+</sup> efflux system in cardiac mitochondria. This molecular identification enabled us to determine structure–function relationships, as well as physiological/pathophysiological contributions, and our understandings have dramatically increased. In this review, we provide an overview of the recent achievements in relation to NCLX, focusing especially on its heart-specific characteristics, biophysical properties, and spatial distribution in cardiomyocytes, as well as in cardiac mitochondria. In addition, we discuss the roles of NCLX in cardiac functions under physiological and pathophysiological conditions—the generation of rhythmicity, the energy metabolism, the production of reactive oxygen species, and the opening of mitochondrial permeability transition pores. |
| first_indexed | 2024-03-10T04:33:01Z |
| format | Article |
| id | doaj.art-acb17e1a772744f3ba4c8fb1c827bc17 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T04:33:01Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-acb17e1a772744f3ba4c8fb1c827bc172023-11-23T04:00:33ZengMDPI AGBiomolecules2218-273X2021-12-011112187610.3390/biom11121876Physiological and Pathophysiological Roles of Mitochondrial Na<sup>+</sup>-Ca<sup>2+</sup> Exchanger, NCLX, in HeartsAyako Takeuchi0Satoshi Matsuoka1Department of Integrative and Systems Physiology, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, JapanDepartment of Integrative and Systems Physiology, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, JapanIt has been over 10 years since <i>SLC24A6/SLC8B1</i>, coding the Na<sup>+</sup>/Ca<sup>2+</sup>/Li<sup>+</sup> exchanger (NCLX), was identified as the gene responsible for mitochondrial Na<sup>+</sup>-Ca<sup>2+</sup> exchange, a major Ca<sup>2+</sup> efflux system in cardiac mitochondria. This molecular identification enabled us to determine structure–function relationships, as well as physiological/pathophysiological contributions, and our understandings have dramatically increased. In this review, we provide an overview of the recent achievements in relation to NCLX, focusing especially on its heart-specific characteristics, biophysical properties, and spatial distribution in cardiomyocytes, as well as in cardiac mitochondria. In addition, we discuss the roles of NCLX in cardiac functions under physiological and pathophysiological conditions—the generation of rhythmicity, the energy metabolism, the production of reactive oxygen species, and the opening of mitochondrial permeability transition pores.https://www.mdpi.com/2218-273X/11/12/1876mitochondriaheartmitochondrial Na<sup>+</sup>-Ca<sup>2+</sup> exchangerNCLXmetabolismCa<sup>2+</sup> signaling |
| spellingShingle | Ayako Takeuchi Satoshi Matsuoka Physiological and Pathophysiological Roles of Mitochondrial Na<sup>+</sup>-Ca<sup>2+</sup> Exchanger, NCLX, in Hearts Biomolecules mitochondria heart mitochondrial Na<sup>+</sup>-Ca<sup>2+</sup> exchanger NCLX metabolism Ca<sup>2+</sup> signaling |
| title | Physiological and Pathophysiological Roles of Mitochondrial Na<sup>+</sup>-Ca<sup>2+</sup> Exchanger, NCLX, in Hearts |
| title_full | Physiological and Pathophysiological Roles of Mitochondrial Na<sup>+</sup>-Ca<sup>2+</sup> Exchanger, NCLX, in Hearts |
| title_fullStr | Physiological and Pathophysiological Roles of Mitochondrial Na<sup>+</sup>-Ca<sup>2+</sup> Exchanger, NCLX, in Hearts |
| title_full_unstemmed | Physiological and Pathophysiological Roles of Mitochondrial Na<sup>+</sup>-Ca<sup>2+</sup> Exchanger, NCLX, in Hearts |
| title_short | Physiological and Pathophysiological Roles of Mitochondrial Na<sup>+</sup>-Ca<sup>2+</sup> Exchanger, NCLX, in Hearts |
| title_sort | physiological and pathophysiological roles of mitochondrial na sup sup ca sup 2 sup exchanger nclx in hearts |
| topic | mitochondria heart mitochondrial Na<sup>+</sup>-Ca<sup>2+</sup> exchanger NCLX metabolism Ca<sup>2+</sup> signaling |
| url | https://www.mdpi.com/2218-273X/11/12/1876 |
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