IL-17-Producing Regulatory T lymphocytes – Suppressors or Effectors?
Regulatory T (Treg) lymphocytes are a T helper population that controls the intensity of the immune response and maintains immune tolerance by selectively suppressing the activity of effector T lymphocytes. Treg cells are unstable and show high plasticity towards effector T helper populations, and t...
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| Format: | Article |
| Language: | English |
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Kazan Federal University
2023-11-01
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| Series: | Učënye Zapiski Kazanskogo Universiteta. Seriâ Estestvennye Nauki |
| Subjects: | |
| Online Access: | https://uzakuesc.elpub.ru/jour/article/view/6 |
| _version_ | 1797258801399726080 |
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| author | E. M. Kuklina N. S. Glebezdina |
| author_facet | E. M. Kuklina N. S. Glebezdina |
| author_sort | E. M. Kuklina |
| collection | DOAJ |
| description | Regulatory T (Treg) lymphocytes are a T helper population that controls the intensity of the immune response and maintains immune tolerance by selectively suppressing the activity of effector T lymphocytes. Treg cells are unstable and show high plasticity towards effector T helper populations, and the most common variant is Treg redifferentiation into T helpers producing interleukin-17 (IL-17 (Th17)). Although their formation has been confirmed by many studies in vivo and in vitro, Treg cells remain poorly understood in terms of their functional activity. The latter is yet fundamentally important for two major reasons. Firstly, an increase in the population of IL-17-producing Tregs has been identified for a number of diseases, raising the question of how these cells are involved in the development of pathologies. Secondly, understanding and predicting the behavior of Tregs in a pro-inflammatory environment promotes their therapeutic use. This review article analyzes the functional consequences of the redifferentiation of Treg cells into Th17. |
| first_indexed | 2024-03-08T10:47:27Z |
| format | Article |
| id | doaj.art-acb27185f8da4dcc985689f2bbf42635 |
| institution | Directory Open Access Journal |
| issn | 2542-064X 2500-218X |
| language | English |
| last_indexed | 2024-04-24T22:59:18Z |
| publishDate | 2023-11-01 |
| publisher | Kazan Federal University |
| record_format | Article |
| series | Učënye Zapiski Kazanskogo Universiteta. Seriâ Estestvennye Nauki |
| spelling | doaj.art-acb27185f8da4dcc985689f2bbf426352024-03-17T16:27:32ZengKazan Federal UniversityUčënye Zapiski Kazanskogo Universiteta. Seriâ Estestvennye Nauki2542-064X2500-218X2023-11-01165339341010.26907/2542-064X.2023.3.393-4105IL-17-Producing Regulatory T lymphocytes – Suppressors or Effectors?E. M. Kuklina0N. S. Glebezdina1Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of SciencesInstitute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of SciencesRegulatory T (Treg) lymphocytes are a T helper population that controls the intensity of the immune response and maintains immune tolerance by selectively suppressing the activity of effector T lymphocytes. Treg cells are unstable and show high plasticity towards effector T helper populations, and the most common variant is Treg redifferentiation into T helpers producing interleukin-17 (IL-17 (Th17)). Although their formation has been confirmed by many studies in vivo and in vitro, Treg cells remain poorly understood in terms of their functional activity. The latter is yet fundamentally important for two major reasons. Firstly, an increase in the population of IL-17-producing Tregs has been identified for a number of diseases, raising the question of how these cells are involved in the development of pathologies. Secondly, understanding and predicting the behavior of Tregs in a pro-inflammatory environment promotes their therapeutic use. This review article analyzes the functional consequences of the redifferentiation of Treg cells into Th17.https://uzakuesc.elpub.ru/jour/article/view/6il-17f+foxp3+ t lymphocytestregth17redifferentiation |
| spellingShingle | E. M. Kuklina N. S. Glebezdina IL-17-Producing Regulatory T lymphocytes – Suppressors or Effectors? Učënye Zapiski Kazanskogo Universiteta. Seriâ Estestvennye Nauki il-17f+foxp3+ t lymphocytes treg th17 redifferentiation |
| title | IL-17-Producing Regulatory T lymphocytes – Suppressors or Effectors? |
| title_full | IL-17-Producing Regulatory T lymphocytes – Suppressors or Effectors? |
| title_fullStr | IL-17-Producing Regulatory T lymphocytes – Suppressors or Effectors? |
| title_full_unstemmed | IL-17-Producing Regulatory T lymphocytes – Suppressors or Effectors? |
| title_short | IL-17-Producing Regulatory T lymphocytes – Suppressors or Effectors? |
| title_sort | il 17 producing regulatory t lymphocytes suppressors or effectors |
| topic | il-17f+foxp3+ t lymphocytes treg th17 redifferentiation |
| url | https://uzakuesc.elpub.ru/jour/article/view/6 |
| work_keys_str_mv | AT emkuklina il17producingregulatorytlymphocytessuppressorsoreffectors AT nsglebezdina il17producingregulatorytlymphocytessuppressorsoreffectors |