Hard polymeric porous microneedles on stretchable substrate for transdermal drug delivery
Abstract Microneedles offer a convenient transdermal delivery route with potential for long term sustained release of drugs. However current microneedle technologies may not have the mechanical properties for reliable and stable penetration (e.g. hydrogel microneedles). Moreover, it is also challeng...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-05912-6 |
| _version_ | 1818486438697631744 |
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| author | Aydin Sadeqi Gita Kiaee Wenxin Zeng Hojatollah Rezaei Nejad Sameer Sonkusale |
| author_facet | Aydin Sadeqi Gita Kiaee Wenxin Zeng Hojatollah Rezaei Nejad Sameer Sonkusale |
| author_sort | Aydin Sadeqi |
| collection | DOAJ |
| description | Abstract Microneedles offer a convenient transdermal delivery route with potential for long term sustained release of drugs. However current microneedle technologies may not have the mechanical properties for reliable and stable penetration (e.g. hydrogel microneedles). Moreover, it is also challenging to realize microneedle arrays with large size and high flexibility. There is also an inherent upper limit to the amount and kind of drugs that can be loaded in the microneedles. In this paper, we present a new class of polymeric porous microneedles made from biocompatible and photo-curable resin that address these challenges. The microneedles are unique in their ability to load solid drug formulation in concentrated form. We demonstrate the loading and release of solid formulation of anesthetic and non-steroidal anti-inflammatory drugs, namely Lidocaine and Ibuprofen. Paper also demonstrates realization of large area (6 × 20 cm2) flexible and stretchable microneedle patches capable of drug delivery on any body part. Penetration studies were performed in an ex vivo porcine model supplemented through rigorous compression tests to ensure the robustness and rigidity of the microneedles. Detailed release profiles of the microneedle patches were shown in an in vitro skin model. Results show promise for large area transdermal delivery of solid drug formulations using these porous microneedles. |
| first_indexed | 2024-12-10T16:23:01Z |
| format | Article |
| id | doaj.art-acb2cf578d2848598e1abde59ac07c55 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-10T16:23:01Z |
| publishDate | 2022-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-acb2cf578d2848598e1abde59ac07c552022-12-22T01:41:46ZengNature PortfolioScientific Reports2045-23222022-02-0112111010.1038/s41598-022-05912-6Hard polymeric porous microneedles on stretchable substrate for transdermal drug deliveryAydin Sadeqi0Gita Kiaee1Wenxin Zeng2Hojatollah Rezaei Nejad3Sameer Sonkusale4Nano Lab, Advanced Technology Laboratory, Tufts UniversityNano Lab, Advanced Technology Laboratory, Tufts UniversityNano Lab, Advanced Technology Laboratory, Tufts UniversityNano Lab, Advanced Technology Laboratory, Tufts UniversityNano Lab, Advanced Technology Laboratory, Tufts UniversityAbstract Microneedles offer a convenient transdermal delivery route with potential for long term sustained release of drugs. However current microneedle technologies may not have the mechanical properties for reliable and stable penetration (e.g. hydrogel microneedles). Moreover, it is also challenging to realize microneedle arrays with large size and high flexibility. There is also an inherent upper limit to the amount and kind of drugs that can be loaded in the microneedles. In this paper, we present a new class of polymeric porous microneedles made from biocompatible and photo-curable resin that address these challenges. The microneedles are unique in their ability to load solid drug formulation in concentrated form. We demonstrate the loading and release of solid formulation of anesthetic and non-steroidal anti-inflammatory drugs, namely Lidocaine and Ibuprofen. Paper also demonstrates realization of large area (6 × 20 cm2) flexible and stretchable microneedle patches capable of drug delivery on any body part. Penetration studies were performed in an ex vivo porcine model supplemented through rigorous compression tests to ensure the robustness and rigidity of the microneedles. Detailed release profiles of the microneedle patches were shown in an in vitro skin model. Results show promise for large area transdermal delivery of solid drug formulations using these porous microneedles.https://doi.org/10.1038/s41598-022-05912-6 |
| spellingShingle | Aydin Sadeqi Gita Kiaee Wenxin Zeng Hojatollah Rezaei Nejad Sameer Sonkusale Hard polymeric porous microneedles on stretchable substrate for transdermal drug delivery Scientific Reports |
| title | Hard polymeric porous microneedles on stretchable substrate for transdermal drug delivery |
| title_full | Hard polymeric porous microneedles on stretchable substrate for transdermal drug delivery |
| title_fullStr | Hard polymeric porous microneedles on stretchable substrate for transdermal drug delivery |
| title_full_unstemmed | Hard polymeric porous microneedles on stretchable substrate for transdermal drug delivery |
| title_short | Hard polymeric porous microneedles on stretchable substrate for transdermal drug delivery |
| title_sort | hard polymeric porous microneedles on stretchable substrate for transdermal drug delivery |
| url | https://doi.org/10.1038/s41598-022-05912-6 |
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