Correlation Analysis of Helicobacter pylori Infection and Digestive Tract Symptoms in Children and Related Factors of Infection
Background: To analyze the correlation between Helicobacter pylori infection and digestive tract symptoms in children and other related factors, and to explore the risk factors of H. pylori infection in children and the expression of inflammatory factors in H. pylori-positive and H. pylori-negative...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2020-10-01
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| Series: | Iranian Journal of Public Health |
| Subjects: | |
| Online Access: | https://ijph.tums.ac.ir/index.php/ijph/article/view/20072 |
| _version_ | 1818896397897826304 |
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| author | Xiaohong YU Dongjin FENG Guangmeng WANG Zhongmao DONG Qi ZHOU Yuan ZHANG |
| author_facet | Xiaohong YU Dongjin FENG Guangmeng WANG Zhongmao DONG Qi ZHOU Yuan ZHANG |
| author_sort | Xiaohong YU |
| collection | DOAJ |
| description | Background: To analyze the correlation between Helicobacter pylori infection and digestive tract symptoms in children and other related factors, and to explore the risk factors of H. pylori infection in children and the expression of inflammatory factors in H. pylori-positive and H. pylori-negative children.
Methods: Overall, 234 children with H. pylori test in Xuzhou Children's Hospital, Xuzhou Medical University (Xuzhou, China) were enrolled. Among them, 73 children were H. pylori-positive and 161 were H. pylori-negative. The expression levels of cytokines interleukin-8 (IL-8), interleukin-18 (IL-18) and interferon-γ (IFN-γ) in H. pylori-positive and H. pylori-negative children were determined by ELISA. The correlation between H. pylori-positive and general data, digestive tract symptoms, other clinical symptoms, living habits, eating habits, family history and other related factors was statistically analyzed. Multivariate Logistic regression analysis was used to analyze the independent risk factors of H. pylori infection in children.
Results: Family monthly income, inattentive eating, sharing toothbrushes and cups, gnawing fingers, eating fried food, drinking raw water, eating smoked and pickled food, father suffering from gastropathy and mother suffering from gastropathy were independent risk factors for H. pylori infection in children. The most common digestive tract symptoms of children with H. pylori infection were abdominal pain, accompanied by one or more clinical symptoms. The expression levels of IL-8, IL-18 and IFN-γ in H. pylori-positive children were significantly higher than those in H. pylori-negative children.
Conclusion: Prevention of H. pylori infection in children is helpful for healthy growth of children, and cytokines IL-8, IL-18, IFN-γ have the potential to be used as biomarkers for diagnosis of H. pylori-positive children. |
| first_indexed | 2024-12-19T18:59:38Z |
| format | Article |
| id | doaj.art-acb329a90cb148db97be3f1f67d25ac4 |
| institution | Directory Open Access Journal |
| issn | 2251-6085 2251-6093 |
| language | English |
| last_indexed | 2024-12-19T18:59:38Z |
| publishDate | 2020-10-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Public Health |
| spelling | doaj.art-acb329a90cb148db97be3f1f67d25ac42022-12-21T20:09:36ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852251-60932020-10-01491010.18502/ijph.v49i10.4694Correlation Analysis of Helicobacter pylori Infection and Digestive Tract Symptoms in Children and Related Factors of InfectionXiaohong YU0Dongjin FENG1Guangmeng WANG2Zhongmao DONG3Qi ZHOU4Yuan ZHANG5Digestive System Department, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou 221000, P.R. ChinaDigestive System Department, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou 221000, P.R. ChinaDigestive System Department, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou 221000, P.R. ChinaDigestive System Department, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou 221000, P.R. ChinaDigestive System Department, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou 221000, P.R. ChinaDigestive System Department, Xuzhou Children's Hospital, Xuzhou Medical UniverBackground: To analyze the correlation between Helicobacter pylori infection and digestive tract symptoms in children and other related factors, and to explore the risk factors of H. pylori infection in children and the expression of inflammatory factors in H. pylori-positive and H. pylori-negative children. Methods: Overall, 234 children with H. pylori test in Xuzhou Children's Hospital, Xuzhou Medical University (Xuzhou, China) were enrolled. Among them, 73 children were H. pylori-positive and 161 were H. pylori-negative. The expression levels of cytokines interleukin-8 (IL-8), interleukin-18 (IL-18) and interferon-γ (IFN-γ) in H. pylori-positive and H. pylori-negative children were determined by ELISA. The correlation between H. pylori-positive and general data, digestive tract symptoms, other clinical symptoms, living habits, eating habits, family history and other related factors was statistically analyzed. Multivariate Logistic regression analysis was used to analyze the independent risk factors of H. pylori infection in children. Results: Family monthly income, inattentive eating, sharing toothbrushes and cups, gnawing fingers, eating fried food, drinking raw water, eating smoked and pickled food, father suffering from gastropathy and mother suffering from gastropathy were independent risk factors for H. pylori infection in children. The most common digestive tract symptoms of children with H. pylori infection were abdominal pain, accompanied by one or more clinical symptoms. The expression levels of IL-8, IL-18 and IFN-γ in H. pylori-positive children were significantly higher than those in H. pylori-negative children. Conclusion: Prevention of H. pylori infection in children is helpful for healthy growth of children, and cytokines IL-8, IL-18, IFN-γ have the potential to be used as biomarkers for diagnosis of H. pylori-positive children.https://ijph.tums.ac.ir/index.php/ijph/article/view/20072Helicobacter pyloriInfectionDigestive tract symptomsRisk factorsCytokines |
| spellingShingle | Xiaohong YU Dongjin FENG Guangmeng WANG Zhongmao DONG Qi ZHOU Yuan ZHANG Correlation Analysis of Helicobacter pylori Infection and Digestive Tract Symptoms in Children and Related Factors of Infection Iranian Journal of Public Health Helicobacter pylori Infection Digestive tract symptoms Risk factors Cytokines |
| title | Correlation Analysis of Helicobacter pylori Infection and Digestive Tract Symptoms in Children and Related Factors of Infection |
| title_full | Correlation Analysis of Helicobacter pylori Infection and Digestive Tract Symptoms in Children and Related Factors of Infection |
| title_fullStr | Correlation Analysis of Helicobacter pylori Infection and Digestive Tract Symptoms in Children and Related Factors of Infection |
| title_full_unstemmed | Correlation Analysis of Helicobacter pylori Infection and Digestive Tract Symptoms in Children and Related Factors of Infection |
| title_short | Correlation Analysis of Helicobacter pylori Infection and Digestive Tract Symptoms in Children and Related Factors of Infection |
| title_sort | correlation analysis of helicobacter pylori infection and digestive tract symptoms in children and related factors of infection |
| topic | Helicobacter pylori Infection Digestive tract symptoms Risk factors Cytokines |
| url | https://ijph.tums.ac.ir/index.php/ijph/article/view/20072 |
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