DNMTs inhibitor Procyanidin B2 reactivates PTEN’s regulatory effects on abnormal glucose metabolism in gastric cancer

DNMTs inhibitor Procyanidin B2 reactivates PTEN’s regulatory effects on abnormal glucose metabolism in gastric cancer

Tumor suppressor PTEN was aberrant silenced in gastric cancer (GC) in our previous study. Activation of PTEN through DNA demethylation is a potential strategy for the treatment of GC. Procyanidin B2 (PB2), an effective DNMT inhibitor, exert positive effects on various diseases. In our work, PB2 supp...

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Hlavní autoři: Donghui Cao, Zhifang Jia, Yanhua Wu, Tongrong Su, Yingli Fu, Yingnan Cui, Yuanlin Sun, Yuzheng Zhang, Dongming Li, Yangyu Zhang, Tetsuya Tsukamoto, Jing Jiang, Xueyuan Cao
Médium: Článek
Jazyk:English
Vydáno: Elsevier 2024-03-01
Edice:Journal of Functional Foods
On-line přístup:http://www.sciencedirect.com/science/article/pii/S1756464624000550

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