Phytochemical-based nanodrugs going beyond the state-of-the-art in cancer management—Targeting cancer stem cells in the framework of predictive, preventive, personalized medicine
Cancer causes many deaths worldwide each year, especially due to tumor heterogeneity leading to disease progression and treatment failure. Targeted treatment of heterogeneous population of cells - cancer stem cells is still an issue in protecting affected individuals against associated multidrug res...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1121950/full |
| _version_ | 1827981767425916928 |
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| author | Lenka Koklesova Jana Jakubikova Jana Jakubikova Dana Cholujova Dana Cholujova Marek Samec Alena Mazurakova Miroslava Šudomová Martin Pec Sherif T. S. Hassan Kamil Biringer Dietrich Büsselberg Tatiana Hurtova Olga Golubnitschaja Peter Kubatka |
| author_facet | Lenka Koklesova Jana Jakubikova Jana Jakubikova Dana Cholujova Dana Cholujova Marek Samec Alena Mazurakova Miroslava Šudomová Martin Pec Sherif T. S. Hassan Kamil Biringer Dietrich Büsselberg Tatiana Hurtova Olga Golubnitschaja Peter Kubatka |
| author_sort | Lenka Koklesova |
| collection | DOAJ |
| description | Cancer causes many deaths worldwide each year, especially due to tumor heterogeneity leading to disease progression and treatment failure. Targeted treatment of heterogeneous population of cells - cancer stem cells is still an issue in protecting affected individuals against associated multidrug resistance and disease progression. Nanotherapeutic agents have the potential to go beyond state-of-the-art approaches in overall cancer management. Specially assembled nanoparticles act as carriers for targeted drug delivery. Several nanodrugs have already been approved by the US Food and Drug Administration (FDA) for treating different cancer types. Phytochemicals isolated from plants demonstrate considerable potential for nanomedical applications in oncology thanks to their antioxidant, anti-inflammatory, anti-proliferative, and other health benefits. Phytochemical-based NPs can enhance anticancer therapeutic effects, improve cellular uptake of therapeutic agents, and mitigate the side effects of toxic anticancer treatments. Per evidence, phytochemical-based NPs can specifically target CSCs decreasing risks of tumor relapse and metastatic disease manifestation. Therefore, this review focuses on current outlook of phytochemical-based NPs and their potential targeting CSCs in cancer research studies and their consideration in the framework of predictive, preventive, and personalized medicine (3PM). |
| first_indexed | 2024-04-09T22:14:19Z |
| format | Article |
| id | doaj.art-acb3eb4df5d04e828d51a0d3755618d1 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-09T22:14:19Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-acb3eb4df5d04e828d51a0d3755618d12023-03-23T05:20:09ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-03-011410.3389/fphar.2023.11219501121950Phytochemical-based nanodrugs going beyond the state-of-the-art in cancer management—Targeting cancer stem cells in the framework of predictive, preventive, personalized medicineLenka Koklesova0Jana Jakubikova1Jana Jakubikova2Dana Cholujova3Dana Cholujova4Marek Samec5Alena Mazurakova6Miroslava Šudomová7Martin Pec8Sherif T. S. Hassan9Kamil Biringer10Dietrich Büsselberg11Tatiana Hurtova12Olga Golubnitschaja13Peter Kubatka14Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, SlovakiaCancer Research Institute, Department of Tumor Immunology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, SlovakiaCentre for Advanced Material Application, Slovak Academy of Sciences, Bratislava, SlovakiaCancer Research Institute, Department of Tumor Immunology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, SlovakiaCentre for Advanced Material Application, Slovak Academy of Sciences, Bratislava, SlovakiaDepartment of Pathological Physiology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, SlovakiaDepartment of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, SlovakiaMuseum of Literature in Moravia, Rajhrad, Czech RepublicDepartment of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, SlovakiaDepartment of Applied Ecology, Faculty of Environmental Sciences, Czech University of Life Sciences Prague, Prague, Czech RepublicClinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, SlovakiaDepartment of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha, QatarDepartment of Dermatology, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin and University Hospital Martin, Martin, Slovakia0Predictive, Preventive, Personalised (3P) Medicine, Department of Radiation Oncology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, GermanyDepartment of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, SlovakiaCancer causes many deaths worldwide each year, especially due to tumor heterogeneity leading to disease progression and treatment failure. Targeted treatment of heterogeneous population of cells - cancer stem cells is still an issue in protecting affected individuals against associated multidrug resistance and disease progression. Nanotherapeutic agents have the potential to go beyond state-of-the-art approaches in overall cancer management. Specially assembled nanoparticles act as carriers for targeted drug delivery. Several nanodrugs have already been approved by the US Food and Drug Administration (FDA) for treating different cancer types. Phytochemicals isolated from plants demonstrate considerable potential for nanomedical applications in oncology thanks to their antioxidant, anti-inflammatory, anti-proliferative, and other health benefits. Phytochemical-based NPs can enhance anticancer therapeutic effects, improve cellular uptake of therapeutic agents, and mitigate the side effects of toxic anticancer treatments. Per evidence, phytochemical-based NPs can specifically target CSCs decreasing risks of tumor relapse and metastatic disease manifestation. Therefore, this review focuses on current outlook of phytochemical-based NPs and their potential targeting CSCs in cancer research studies and their consideration in the framework of predictive, preventive, and personalized medicine (3PM).https://www.frontiersin.org/articles/10.3389/fphar.2023.1121950/fullnanomedicinenanoparticlesphytochemicalsplant-derived foodscancer stem cells therapypredictive preventive personalized medicine |
| spellingShingle | Lenka Koklesova Jana Jakubikova Jana Jakubikova Dana Cholujova Dana Cholujova Marek Samec Alena Mazurakova Miroslava Šudomová Martin Pec Sherif T. S. Hassan Kamil Biringer Dietrich Büsselberg Tatiana Hurtova Olga Golubnitschaja Peter Kubatka Phytochemical-based nanodrugs going beyond the state-of-the-art in cancer management—Targeting cancer stem cells in the framework of predictive, preventive, personalized medicine Frontiers in Pharmacology nanomedicine nanoparticles phytochemicals plant-derived foods cancer stem cells therapy predictive preventive personalized medicine |
| title | Phytochemical-based nanodrugs going beyond the state-of-the-art in cancer management—Targeting cancer stem cells in the framework of predictive, preventive, personalized medicine |
| title_full | Phytochemical-based nanodrugs going beyond the state-of-the-art in cancer management—Targeting cancer stem cells in the framework of predictive, preventive, personalized medicine |
| title_fullStr | Phytochemical-based nanodrugs going beyond the state-of-the-art in cancer management—Targeting cancer stem cells in the framework of predictive, preventive, personalized medicine |
| title_full_unstemmed | Phytochemical-based nanodrugs going beyond the state-of-the-art in cancer management—Targeting cancer stem cells in the framework of predictive, preventive, personalized medicine |
| title_short | Phytochemical-based nanodrugs going beyond the state-of-the-art in cancer management—Targeting cancer stem cells in the framework of predictive, preventive, personalized medicine |
| title_sort | phytochemical based nanodrugs going beyond the state of the art in cancer management targeting cancer stem cells in the framework of predictive preventive personalized medicine |
| topic | nanomedicine nanoparticles phytochemicals plant-derived foods cancer stem cells therapy predictive preventive personalized medicine |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1121950/full |
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