Healthcare-associated Infections by Pseudomonas aeruginosa and Antimicrobial Resistance in a Public Hospital from Alagoas (Brazil)
ABSTRACT Introduction Pseudomonas aeruginosa infections are common worldwide, affecting mainly hospitalized patients and causing healthcare-associated infections (HAIs), with a high frequency of antibiotic resistance and complicated outcomes. Objective To investigate the P. aeruginosa frequency i...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Patologia Clínica
2022-05-01
|
| Series: | Jornal Brasileiro de Patologia e Medicina Laboratorial |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442022000100106&lng=en&tlng=en |
| _version_ | 1817976648800141312 |
|---|---|
| author | Maria Anilda dos Santos Araújo Joiciane Santos Rodrigues Teresa de Lisieux Guedes Ferreira Lobo Fernanda Cristina de Albuquerque Maranhão |
| author_facet | Maria Anilda dos Santos Araújo Joiciane Santos Rodrigues Teresa de Lisieux Guedes Ferreira Lobo Fernanda Cristina de Albuquerque Maranhão |
| author_sort | Maria Anilda dos Santos Araújo |
| collection | DOAJ |
| description | ABSTRACT Introduction Pseudomonas aeruginosa infections are common worldwide, affecting mainly hospitalized patients and causing healthcare-associated infections (HAIs), with a high frequency of antibiotic resistance and complicated outcomes. Objective To investigate the P. aeruginosa frequency in HAIs in a medium/high-complexity hospital in Alagoas (Brazil) and the antibiotic susceptibility profiles of the strains. Methods A retrospective cross-sectional study was conducted from January 2013 to December 2014, when P. aeruginosa related-HAIs were evaluated after automated identification (Vitek®2) and documental analysis. Results Seventy-eight samples were positive for P. aeruginosa, with 37 (47.4%) isolates from patients of the general Intensive Care Unit (ICU) and 13 (16.7%) from the surgical unit. Tracheal secretion (25.6%), wound secretions (20.5%) and sputum (18.0%) were the main positive biological samples. Among 68 strains tested, 73.53% showed resistance to aztreonam, while cefepime, ceftriaxone and cefotaxime were not effective for any isolates (all resistant). High resistance to carbapenems imipenem (61.76%) and meropenem (55.88%) was observed, as well as 46 isolates resistant to piperacillin/tazobactam (67.64%); 47 (60.2%) from the general ICU and neonatal ICU were resistant to all antibiotics tested (MDR profile), except for colistin. Conclusion Our results indicated antibiotic-resistant P. aeruginosa highly present in ICU and the therapy with aminoglycosides and colistin as important choices in cases with failure against P. aeruginosa isolates. A constant screening of multidrug-resistant P. aeruginosa is necessary for the control in the hospital environment, evaluating the antibiotic susceptibility to guide the therapeutic choice. |
| first_indexed | 2024-04-13T22:06:33Z |
| format | Article |
| id | doaj.art-acb54bd2bfec4c82979b8c60af92e9da |
| institution | Directory Open Access Journal |
| issn | 1678-4774 |
| language | English |
| last_indexed | 2024-04-13T22:06:33Z |
| publishDate | 2022-05-01 |
| publisher | Sociedade Brasileira de Patologia Clínica |
| record_format | Article |
| series | Jornal Brasileiro de Patologia e Medicina Laboratorial |
| spelling | doaj.art-acb54bd2bfec4c82979b8c60af92e9da2022-12-22T02:27:56ZengSociedade Brasileira de Patologia ClínicaJornal Brasileiro de Patologia e Medicina Laboratorial1678-47742022-05-015810.1900/jbpml.2022.58.447Healthcare-associated Infections by Pseudomonas aeruginosa and Antimicrobial Resistance in a Public Hospital from Alagoas (Brazil)Maria Anilda dos Santos AraújoJoiciane Santos RodriguesTeresa de Lisieux Guedes Ferreira LoboFernanda Cristina de Albuquerque Maranhãohttps://orcid.org/0000-0002-4255-6563ABSTRACT Introduction Pseudomonas aeruginosa infections are common worldwide, affecting mainly hospitalized patients and causing healthcare-associated infections (HAIs), with a high frequency of antibiotic resistance and complicated outcomes. Objective To investigate the P. aeruginosa frequency in HAIs in a medium/high-complexity hospital in Alagoas (Brazil) and the antibiotic susceptibility profiles of the strains. Methods A retrospective cross-sectional study was conducted from January 2013 to December 2014, when P. aeruginosa related-HAIs were evaluated after automated identification (Vitek®2) and documental analysis. Results Seventy-eight samples were positive for P. aeruginosa, with 37 (47.4%) isolates from patients of the general Intensive Care Unit (ICU) and 13 (16.7%) from the surgical unit. Tracheal secretion (25.6%), wound secretions (20.5%) and sputum (18.0%) were the main positive biological samples. Among 68 strains tested, 73.53% showed resistance to aztreonam, while cefepime, ceftriaxone and cefotaxime were not effective for any isolates (all resistant). High resistance to carbapenems imipenem (61.76%) and meropenem (55.88%) was observed, as well as 46 isolates resistant to piperacillin/tazobactam (67.64%); 47 (60.2%) from the general ICU and neonatal ICU were resistant to all antibiotics tested (MDR profile), except for colistin. Conclusion Our results indicated antibiotic-resistant P. aeruginosa highly present in ICU and the therapy with aminoglycosides and colistin as important choices in cases with failure against P. aeruginosa isolates. A constant screening of multidrug-resistant P. aeruginosa is necessary for the control in the hospital environment, evaluating the antibiotic susceptibility to guide the therapeutic choice.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442022000100106&lng=en&tlng=enPseudomonas aeruginosaantimicrobial resistancehealthcare-associated infectionsICU |
| spellingShingle | Maria Anilda dos Santos Araújo Joiciane Santos Rodrigues Teresa de Lisieux Guedes Ferreira Lobo Fernanda Cristina de Albuquerque Maranhão Healthcare-associated Infections by Pseudomonas aeruginosa and Antimicrobial Resistance in a Public Hospital from Alagoas (Brazil) Jornal Brasileiro de Patologia e Medicina Laboratorial Pseudomonas aeruginosa antimicrobial resistance healthcare-associated infections ICU |
| title | Healthcare-associated Infections by Pseudomonas aeruginosa and Antimicrobial Resistance in a Public Hospital from Alagoas (Brazil) |
| title_full | Healthcare-associated Infections by Pseudomonas aeruginosa and Antimicrobial Resistance in a Public Hospital from Alagoas (Brazil) |
| title_fullStr | Healthcare-associated Infections by Pseudomonas aeruginosa and Antimicrobial Resistance in a Public Hospital from Alagoas (Brazil) |
| title_full_unstemmed | Healthcare-associated Infections by Pseudomonas aeruginosa and Antimicrobial Resistance in a Public Hospital from Alagoas (Brazil) |
| title_short | Healthcare-associated Infections by Pseudomonas aeruginosa and Antimicrobial Resistance in a Public Hospital from Alagoas (Brazil) |
| title_sort | healthcare associated infections by pseudomonas aeruginosa and antimicrobial resistance in a public hospital from alagoas brazil |
| topic | Pseudomonas aeruginosa antimicrobial resistance healthcare-associated infections ICU |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442022000100106&lng=en&tlng=en |
| work_keys_str_mv | AT mariaanildadossantosaraujo healthcareassociatedinfectionsbypseudomonasaeruginosaandantimicrobialresistanceinapublichospitalfromalagoasbrazil AT joicianesantosrodrigues healthcareassociatedinfectionsbypseudomonasaeruginosaandantimicrobialresistanceinapublichospitalfromalagoasbrazil AT teresadelisieuxguedesferreiralobo healthcareassociatedinfectionsbypseudomonasaeruginosaandantimicrobialresistanceinapublichospitalfromalagoasbrazil AT fernandacristinadealbuquerquemaranhao healthcareassociatedinfectionsbypseudomonasaeruginosaandantimicrobialresistanceinapublichospitalfromalagoasbrazil |