Alpha-mannosidosis caused by toxic plants in ruminants of Argentina
Abstract It is well known that several of the swainsonine-containing plant species found widespread around the world have a negative economic impact in each country. In Argentina, most of the information on the poisonous plant species that produce α-mannosidosis is published in Spanish and thus not...
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Academia Brasileira de Ciências
2021-11-01
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| Series: | Anais da Academia Brasileira de Ciências |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000601019&tlng=en |
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| author | LUCIANA A. CHOLICH AGUSTÍN MARTINEZ JUAN F. MICHELOUD MARÍA E. PISTÁN ENRIQUE N. GARCÍA CARLOS A. ROBLES HUGO H. ORTEGA EDUARDO J. GIMENO |
| author_facet | LUCIANA A. CHOLICH AGUSTÍN MARTINEZ JUAN F. MICHELOUD MARÍA E. PISTÁN ENRIQUE N. GARCÍA CARLOS A. ROBLES HUGO H. ORTEGA EDUARDO J. GIMENO |
| author_sort | LUCIANA A. CHOLICH |
| collection | DOAJ |
| description | Abstract It is well known that several of the swainsonine-containing plant species found widespread around the world have a negative economic impact in each country. In Argentina, most of the information on the poisonous plant species that produce α-mannosidosis is published in Spanish and thus not available to most English-speaking researchers interested in toxic plants. Therefore, the aim of this review is to summarize the information about swainsonine-containing plants in Argentina, which are extensively distributed throughout different ecoregions of the country. To date, five species from three genera have been shown to induce α-mannosidosis in livestock in Argentina: Ipomoea carnea subsp. fistulosa, Ipomoea hieronymi subsp. calchaquina (Convolvulaceae), Astragalus garbancillo, Astragalus pehuenches (Fabaceae), and Sida rodrigoi (Malvaceae). These species contain the indolizidine alkaloid swainsonine, which inhibits the lysosomal enzyme α-mannosidase and consequently affects glycoprotein metabolism, resulting in partially metabolized sugars. The prolonged consumption of these poisonous plants produces progressive weight loss and clinical signs related to a nervous disorder, characterized by tremors of head and neck, abnormalities of gait, difficulty in standing, ataxia and wide-based stance. Histological lesions are mainly characterized by vacuolation of different cells, especially neurons of the central nervous system. The main animal model used to study α-mannosidosis is the guinea pig because, when experimentally poisoned, it exhibits many of the characteristics of naturally intoxicated livestock. |
| first_indexed | 2024-12-21T00:04:25Z |
| format | Article |
| id | doaj.art-acb5d4cefe334448a15dab7bdd782032 |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-12-21T00:04:25Z |
| publishDate | 2021-11-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-acb5d4cefe334448a15dab7bdd7820322022-12-21T19:22:32ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902021-11-0193suppl 310.1590/0001-3765202120191496Alpha-mannosidosis caused by toxic plants in ruminants of ArgentinaLUCIANA A. CHOLICHhttps://orcid.org/0000-0002-7936-8806AGUSTÍN MARTINEZhttps://orcid.org/0000-0002-1917-1104JUAN F. MICHELOUDhttps://orcid.org/0000-0001-8709-895XMARÍA E. PISTÁNhttps://orcid.org/0000-0001-8210-7060ENRIQUE N. GARCÍAhttps://orcid.org/0000-0002-4224-0083CARLOS A. ROBLEShttps://orcid.org/0000-0002-1265-2941HUGO H. ORTEGAhttps://orcid.org/0000-0002-7663-3133EDUARDO J. GIMENOhttps://orcid.org/0000-0003-1470-3738Abstract It is well known that several of the swainsonine-containing plant species found widespread around the world have a negative economic impact in each country. In Argentina, most of the information on the poisonous plant species that produce α-mannosidosis is published in Spanish and thus not available to most English-speaking researchers interested in toxic plants. Therefore, the aim of this review is to summarize the information about swainsonine-containing plants in Argentina, which are extensively distributed throughout different ecoregions of the country. To date, five species from three genera have been shown to induce α-mannosidosis in livestock in Argentina: Ipomoea carnea subsp. fistulosa, Ipomoea hieronymi subsp. calchaquina (Convolvulaceae), Astragalus garbancillo, Astragalus pehuenches (Fabaceae), and Sida rodrigoi (Malvaceae). These species contain the indolizidine alkaloid swainsonine, which inhibits the lysosomal enzyme α-mannosidase and consequently affects glycoprotein metabolism, resulting in partially metabolized sugars. The prolonged consumption of these poisonous plants produces progressive weight loss and clinical signs related to a nervous disorder, characterized by tremors of head and neck, abnormalities of gait, difficulty in standing, ataxia and wide-based stance. Histological lesions are mainly characterized by vacuolation of different cells, especially neurons of the central nervous system. The main animal model used to study α-mannosidosis is the guinea pig because, when experimentally poisoned, it exhibits many of the characteristics of naturally intoxicated livestock.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000601019&tlng=enArgentinaguinea pig modellivestockneuronal vacuolationpoisonous plantsswainsonine |
| spellingShingle | LUCIANA A. CHOLICH AGUSTÍN MARTINEZ JUAN F. MICHELOUD MARÍA E. PISTÁN ENRIQUE N. GARCÍA CARLOS A. ROBLES HUGO H. ORTEGA EDUARDO J. GIMENO Alpha-mannosidosis caused by toxic plants in ruminants of Argentina Anais da Academia Brasileira de Ciências Argentina guinea pig model livestock neuronal vacuolation poisonous plants swainsonine |
| title | Alpha-mannosidosis caused by toxic plants in ruminants of Argentina |
| title_full | Alpha-mannosidosis caused by toxic plants in ruminants of Argentina |
| title_fullStr | Alpha-mannosidosis caused by toxic plants in ruminants of Argentina |
| title_full_unstemmed | Alpha-mannosidosis caused by toxic plants in ruminants of Argentina |
| title_short | Alpha-mannosidosis caused by toxic plants in ruminants of Argentina |
| title_sort | alpha mannosidosis caused by toxic plants in ruminants of argentina |
| topic | Argentina guinea pig model livestock neuronal vacuolation poisonous plants swainsonine |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000601019&tlng=en |
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