A novel dosage form for buccal administration of bupropion
Bupropion is an antidepressant used in the treatment of smoking. The purpose of this study was to prepare controlled-release hydrogel films for buccal administration of bupropion and investigate its physicochemical and cytotoxic properties. The films were prepared from ultrapure sodium carboxymethyl...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universidade de São Paulo
2015-03-01
|
| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100091&lng=en&tlng=en |
| _version_ | 1818357686773743616 |
|---|---|
| author | Nilsa Maria Galvão Almeida Renata Lima Thaís Francine Ribeiro Alves Márcia de Araújo Rebelo Patrícia Severino Marco Vinícius Chaud |
| author_facet | Nilsa Maria Galvão Almeida Renata Lima Thaís Francine Ribeiro Alves Márcia de Araújo Rebelo Patrícia Severino Marco Vinícius Chaud |
| author_sort | Nilsa Maria Galvão Almeida |
| collection | DOAJ |
| description | Bupropion is an antidepressant used in the treatment of smoking. The purpose of this study was to prepare controlled-release hydrogel films for buccal administration of bupropion and investigate its physicochemical and cytotoxic properties. The films were prepared from ultrapure sodium carboxymethylcellulose, hydroxypropylmethylcellulose K4M, and medium-viscosity chitosan. Evaluation of film physicochemical characteristics was based on scanning electron microscopy, bupropion content, mechanical strength (burst strength, relaxation, resilience, and traction), and cytotoxicity. Bupropion content in bilayer films was 121 mg per 9 cm2. The presence of bupropion modified film mechanical strength, but did not compromise the use of this pharmaceutical form. As shown by the cytotoxicity results, films containing bupropion did not cause cellular damage. Bupropion administration in the form of hydrogel films is a potentially useful alternative in the treatment of smoking. |
| first_indexed | 2024-12-13T20:17:03Z |
| format | Article |
| id | doaj.art-acb7566c35f14496a17b682275fb3df8 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-12-13T20:17:03Z |
| publishDate | 2015-03-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-acb7566c35f14496a17b682275fb3df82022-12-21T23:32:48ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902015-03-015119110010.1590/S1984-82502015000100010S1984-82502015000100091A novel dosage form for buccal administration of bupropionNilsa Maria Galvão AlmeidaRenata LimaThaís Francine Ribeiro AlvesMárcia de Araújo RebeloPatrícia SeverinoMarco Vinícius ChaudBupropion is an antidepressant used in the treatment of smoking. The purpose of this study was to prepare controlled-release hydrogel films for buccal administration of bupropion and investigate its physicochemical and cytotoxic properties. The films were prepared from ultrapure sodium carboxymethylcellulose, hydroxypropylmethylcellulose K4M, and medium-viscosity chitosan. Evaluation of film physicochemical characteristics was based on scanning electron microscopy, bupropion content, mechanical strength (burst strength, relaxation, resilience, and traction), and cytotoxicity. Bupropion content in bilayer films was 121 mg per 9 cm2. The presence of bupropion modified film mechanical strength, but did not compromise the use of this pharmaceutical form. As shown by the cytotoxicity results, films containing bupropion did not cause cellular damage. Bupropion administration in the form of hydrogel films is a potentially useful alternative in the treatment of smoking.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100091&lng=en&tlng=enBupropiona/administração bucalFilmes em bicamada/liberação de fármacosFármacos/liberação controladaTabagismo/controle |
| spellingShingle | Nilsa Maria Galvão Almeida Renata Lima Thaís Francine Ribeiro Alves Márcia de Araújo Rebelo Patrícia Severino Marco Vinícius Chaud A novel dosage form for buccal administration of bupropion Brazilian Journal of Pharmaceutical Sciences Bupropiona/administração bucal Filmes em bicamada/liberação de fármacos Fármacos/liberação controlada Tabagismo/controle |
| title | A novel dosage form for buccal administration of bupropion |
| title_full | A novel dosage form for buccal administration of bupropion |
| title_fullStr | A novel dosage form for buccal administration of bupropion |
| title_full_unstemmed | A novel dosage form for buccal administration of bupropion |
| title_short | A novel dosage form for buccal administration of bupropion |
| title_sort | novel dosage form for buccal administration of bupropion |
| topic | Bupropiona/administração bucal Filmes em bicamada/liberação de fármacos Fármacos/liberação controlada Tabagismo/controle |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100091&lng=en&tlng=en |
| work_keys_str_mv | AT nilsamariagalvaoalmeida anoveldosageformforbuccaladministrationofbupropion AT renatalima anoveldosageformforbuccaladministrationofbupropion AT thaisfrancineribeiroalves anoveldosageformforbuccaladministrationofbupropion AT marciadearaujorebelo anoveldosageformforbuccaladministrationofbupropion AT patriciaseverino anoveldosageformforbuccaladministrationofbupropion AT marcoviniciuschaud anoveldosageformforbuccaladministrationofbupropion AT nilsamariagalvaoalmeida noveldosageformforbuccaladministrationofbupropion AT renatalima noveldosageformforbuccaladministrationofbupropion AT thaisfrancineribeiroalves noveldosageformforbuccaladministrationofbupropion AT marciadearaujorebelo noveldosageformforbuccaladministrationofbupropion AT patriciaseverino noveldosageformforbuccaladministrationofbupropion AT marcoviniciuschaud noveldosageformforbuccaladministrationofbupropion |