Binding of HMGN proteins to cell specific enhancers stabilizes cell identity
HMGN1 and HMGN2 are ubiquitous nucleosome binding proteins. Here the authors provide evidence that HMGN proteins preferentially localize to chromatin regulatory sites to modulate the plasticity of the epigenetic landscape, proposing that HGMNs stabilize, rather than determine, cell identity.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07687-9 |
| _version_ | 1818427128194007040 |
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| author | Bing He Tao Deng Iris Zhu Takashi Furusawa Shaofei Zhang Wei Tang Yuri Postnikov Stefan Ambs Caiyi Cherry Li Ferenc Livak David Landsman Michael Bustin |
| author_facet | Bing He Tao Deng Iris Zhu Takashi Furusawa Shaofei Zhang Wei Tang Yuri Postnikov Stefan Ambs Caiyi Cherry Li Ferenc Livak David Landsman Michael Bustin |
| author_sort | Bing He |
| collection | DOAJ |
| description | HMGN1 and HMGN2 are ubiquitous nucleosome binding proteins. Here the authors provide evidence that HMGN proteins preferentially localize to chromatin regulatory sites to modulate the plasticity of the epigenetic landscape, proposing that HGMNs stabilize, rather than determine, cell identity. |
| first_indexed | 2024-12-14T14:40:48Z |
| format | Article |
| id | doaj.art-acb87ff987c14ca2b815b9f6f7ffe5ff |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T14:40:48Z |
| publishDate | 2018-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-acb87ff987c14ca2b815b9f6f7ffe5ff2022-12-21T22:57:26ZengNature PortfolioNature Communications2041-17232018-12-019111410.1038/s41467-018-07687-9Binding of HMGN proteins to cell specific enhancers stabilizes cell identityBing He0Tao Deng1Iris Zhu2Takashi Furusawa3Shaofei Zhang4Wei Tang5Yuri Postnikov6Stefan Ambs7Caiyi Cherry Li8Ferenc Livak9David Landsman10Michael Bustin11Protein Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of HealthProtein Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of HealthComputational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of HealthProtein Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of HealthProtein Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of HealthLaboratory of Human Carcinogenesis, Center for Cancer Research, National Institutes of HealthProtein Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of HealthLaboratory of Human Carcinogenesis, Center for Cancer Research, National Institutes of HealthLaboratory of Genomic Integrity, Center for Cancer Research National Cancer Institute National Institutes of HealthLaboratory of Genomic Integrity, Center for Cancer Research National Cancer Institute National Institutes of HealthComputational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of HealthProtein Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of HealthHMGN1 and HMGN2 are ubiquitous nucleosome binding proteins. Here the authors provide evidence that HMGN proteins preferentially localize to chromatin regulatory sites to modulate the plasticity of the epigenetic landscape, proposing that HGMNs stabilize, rather than determine, cell identity.https://doi.org/10.1038/s41467-018-07687-9 |
| spellingShingle | Bing He Tao Deng Iris Zhu Takashi Furusawa Shaofei Zhang Wei Tang Yuri Postnikov Stefan Ambs Caiyi Cherry Li Ferenc Livak David Landsman Michael Bustin Binding of HMGN proteins to cell specific enhancers stabilizes cell identity Nature Communications |
| title | Binding of HMGN proteins to cell specific enhancers stabilizes cell identity |
| title_full | Binding of HMGN proteins to cell specific enhancers stabilizes cell identity |
| title_fullStr | Binding of HMGN proteins to cell specific enhancers stabilizes cell identity |
| title_full_unstemmed | Binding of HMGN proteins to cell specific enhancers stabilizes cell identity |
| title_short | Binding of HMGN proteins to cell specific enhancers stabilizes cell identity |
| title_sort | binding of hmgn proteins to cell specific enhancers stabilizes cell identity |
| url | https://doi.org/10.1038/s41467-018-07687-9 |
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