Molecular Dynamic Simulations Reveal the Activation Mechanisms of Oxidation-Induced TRPV1

Molecular Dynamic Simulations Reveal the Activation Mechanisms of Oxidation-Induced TRPV1

Transient receptor potential vanilloid 1 (TRPV1), a non-selective cation channel, can be directly activated by oxidants through cysteine modification. However, the patterns of cysteine modification are unclear. Structural analysis showed that the free sulfhydryl groups of residue pairs C387 and C391...

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Bibliographic Details
Main Authors: Yanyan Chu, Huanhuan Zhang, Mengke Yang, Rilei Yu
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
TRPV1
ion channel
allosteric mechanism
accelerated molecular dynamics
disulfide bond
Online Access:https://www.mdpi.com/1422-0067/24/11/9553

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