Umbilical Cord Biometry and Fetal Abdominal Skinfold Assessment as Potential Biomarkers for Fetal Macrosomia in a Gestational Diabetes Romanian Cohort
<i>Background</i><i>and Objectives:</i> Gestational diabetes mellitus (GDM) is a pregnancy-associated pathology commonly resulting in macrosomic fetuses, a known culprit of obstetric complications. We aimed to evaluate the potential of umbilical cord biometry and fetal abdomi...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/58/9/1162 |
| _version_ | 1827659107209838592 |
|---|---|
| author | Andreea Roxana Florian Gheorghe Cruciat Georgiana Nemeti Adelina Staicu Cristina Suciu Mariam Chaikh Sulaiman Iulian Goidescu Daniel Muresan Florin Stamatian |
| author_facet | Andreea Roxana Florian Gheorghe Cruciat Georgiana Nemeti Adelina Staicu Cristina Suciu Mariam Chaikh Sulaiman Iulian Goidescu Daniel Muresan Florin Stamatian |
| author_sort | Andreea Roxana Florian |
| collection | DOAJ |
| description | <i>Background</i><i>and Objectives:</i> Gestational diabetes mellitus (GDM) is a pregnancy-associated pathology commonly resulting in macrosomic fetuses, a known culprit of obstetric complications. We aimed to evaluate the potential of umbilical cord biometry and fetal abdominal skinfold assessment as screening tools for fetal macrosomia in gestational diabetes mellitus pregnant women. <i>Materials and methods:</i> This was a prospective case–control study conducted on pregnant patients presenting at 24–28 weeks of gestation in a tertiary-level maternity hospital in Northern Romania. Fetal biometry, fetal weight estimation, umbilical cord area and circumference, areas of the umbilical vein and arteries, Wharton jelly (WJ) area and abdominal fold thickness measurements were performed. <i>Results:</i> A total of 51 patients were enrolled in the study, 26 patients in the GDM group and 25 patients in the non-GDM group. There was no evidence in favor of umbilical cord area and WJ amount assessments as predictors of fetal macrosomia (<i>p</i> > 0.05). However, there was a statistically significant difference in the abdominal skinfold measurement during the second trimester between macrosomic and normal-weight newborns in the GDM patient group (<i>p</i> = 0.016). The second-trimester abdominal circumference was statistically significantly correlated with fetal macrosomia at term in the GDM patient group with a p value of 0.003, as well as when considering the global prevalence of macrosomia in the studied populations, 0.001, when considering both populations. <i>Conclusions:</i> The measurements of cord and WJ could not be established as predictors of fetal macrosomia in our study populations, nor differentiate between pregnancies with and without GDM. Abdominal skinfold measurement and abdominal circumference measured during the second trimester may be important markers of fetal metabolic status in pregnancies complicated by GDM. |
| first_indexed | 2024-03-09T23:14:57Z |
| format | Article |
| id | doaj.art-acbde24cf98443c1b56720636c7d5800 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T23:14:57Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-acbde24cf98443c1b56720636c7d58002023-11-23T17:38:46ZengMDPI AGMedicina1010-660X1648-91442022-08-01589116210.3390/medicina58091162Umbilical Cord Biometry and Fetal Abdominal Skinfold Assessment as Potential Biomarkers for Fetal Macrosomia in a Gestational Diabetes Romanian CohortAndreea Roxana Florian0Gheorghe Cruciat1Georgiana Nemeti2Adelina Staicu3Cristina Suciu4Mariam Chaikh Sulaiman5Iulian Goidescu6Daniel Muresan7Florin Stamatian8Obstetrics and Gynecology I, Mother and Child Department, University of Medicine and Pharmacy “Iuliu Hatieganu”, 400006 Cluj-Napoca, RomaniaObstetrics and Gynecology I, Mother and Child Department, University of Medicine and Pharmacy “Iuliu Hatieganu”, 400006 Cluj-Napoca, RomaniaObstetrics and Gynecology I, Mother and Child Department, University of Medicine and Pharmacy “Iuliu Hatieganu”, 400006 Cluj-Napoca, RomaniaObstetrics and Gynecology I, Mother and Child Department, University of Medicine and Pharmacy “Iuliu Hatieganu”, 400006 Cluj-Napoca, RomaniaObstetrics and Gynecology I, Mother and Child Department, University of Medicine and Pharmacy “Iuliu Hatieganu”, 400006 Cluj-Napoca, RomaniaObstetrics and Gynecology I, Mother and Child Department, University of Medicine and Pharmacy “Iuliu Hatieganu”, 400006 Cluj-Napoca, RomaniaObstetrics and Gynecology I, Mother and Child Department, University of Medicine and Pharmacy “Iuliu Hatieganu”, 400006 Cluj-Napoca, RomaniaObstetrics and Gynecology I, Mother and Child Department, University of Medicine and Pharmacy “Iuliu Hatieganu”, 400006 Cluj-Napoca, RomaniaImogen Clinical Research Centre, 400006 Cluj-Napoca, Romania<i>Background</i><i>and Objectives:</i> Gestational diabetes mellitus (GDM) is a pregnancy-associated pathology commonly resulting in macrosomic fetuses, a known culprit of obstetric complications. We aimed to evaluate the potential of umbilical cord biometry and fetal abdominal skinfold assessment as screening tools for fetal macrosomia in gestational diabetes mellitus pregnant women. <i>Materials and methods:</i> This was a prospective case–control study conducted on pregnant patients presenting at 24–28 weeks of gestation in a tertiary-level maternity hospital in Northern Romania. Fetal biometry, fetal weight estimation, umbilical cord area and circumference, areas of the umbilical vein and arteries, Wharton jelly (WJ) area and abdominal fold thickness measurements were performed. <i>Results:</i> A total of 51 patients were enrolled in the study, 26 patients in the GDM group and 25 patients in the non-GDM group. There was no evidence in favor of umbilical cord area and WJ amount assessments as predictors of fetal macrosomia (<i>p</i> > 0.05). However, there was a statistically significant difference in the abdominal skinfold measurement during the second trimester between macrosomic and normal-weight newborns in the GDM patient group (<i>p</i> = 0.016). The second-trimester abdominal circumference was statistically significantly correlated with fetal macrosomia at term in the GDM patient group with a p value of 0.003, as well as when considering the global prevalence of macrosomia in the studied populations, 0.001, when considering both populations. <i>Conclusions:</i> The measurements of cord and WJ could not be established as predictors of fetal macrosomia in our study populations, nor differentiate between pregnancies with and without GDM. Abdominal skinfold measurement and abdominal circumference measured during the second trimester may be important markers of fetal metabolic status in pregnancies complicated by GDM.https://www.mdpi.com/1648-9144/58/9/1162gestational diabetes mellitusfetal macrosomiaumbilical cord areaabdominal skinfoldWharton jelly |
| spellingShingle | Andreea Roxana Florian Gheorghe Cruciat Georgiana Nemeti Adelina Staicu Cristina Suciu Mariam Chaikh Sulaiman Iulian Goidescu Daniel Muresan Florin Stamatian Umbilical Cord Biometry and Fetal Abdominal Skinfold Assessment as Potential Biomarkers for Fetal Macrosomia in a Gestational Diabetes Romanian Cohort Medicina gestational diabetes mellitus fetal macrosomia umbilical cord area abdominal skinfold Wharton jelly |
| title | Umbilical Cord Biometry and Fetal Abdominal Skinfold Assessment as Potential Biomarkers for Fetal Macrosomia in a Gestational Diabetes Romanian Cohort |
| title_full | Umbilical Cord Biometry and Fetal Abdominal Skinfold Assessment as Potential Biomarkers for Fetal Macrosomia in a Gestational Diabetes Romanian Cohort |
| title_fullStr | Umbilical Cord Biometry and Fetal Abdominal Skinfold Assessment as Potential Biomarkers for Fetal Macrosomia in a Gestational Diabetes Romanian Cohort |
| title_full_unstemmed | Umbilical Cord Biometry and Fetal Abdominal Skinfold Assessment as Potential Biomarkers for Fetal Macrosomia in a Gestational Diabetes Romanian Cohort |
| title_short | Umbilical Cord Biometry and Fetal Abdominal Skinfold Assessment as Potential Biomarkers for Fetal Macrosomia in a Gestational Diabetes Romanian Cohort |
| title_sort | umbilical cord biometry and fetal abdominal skinfold assessment as potential biomarkers for fetal macrosomia in a gestational diabetes romanian cohort |
| topic | gestational diabetes mellitus fetal macrosomia umbilical cord area abdominal skinfold Wharton jelly |
| url | https://www.mdpi.com/1648-9144/58/9/1162 |
| work_keys_str_mv | AT andreearoxanaflorian umbilicalcordbiometryandfetalabdominalskinfoldassessmentaspotentialbiomarkersforfetalmacrosomiainagestationaldiabetesromaniancohort AT gheorghecruciat umbilicalcordbiometryandfetalabdominalskinfoldassessmentaspotentialbiomarkersforfetalmacrosomiainagestationaldiabetesromaniancohort AT georgiananemeti umbilicalcordbiometryandfetalabdominalskinfoldassessmentaspotentialbiomarkersforfetalmacrosomiainagestationaldiabetesromaniancohort AT adelinastaicu umbilicalcordbiometryandfetalabdominalskinfoldassessmentaspotentialbiomarkersforfetalmacrosomiainagestationaldiabetesromaniancohort AT cristinasuciu umbilicalcordbiometryandfetalabdominalskinfoldassessmentaspotentialbiomarkersforfetalmacrosomiainagestationaldiabetesromaniancohort AT mariamchaikhsulaiman umbilicalcordbiometryandfetalabdominalskinfoldassessmentaspotentialbiomarkersforfetalmacrosomiainagestationaldiabetesromaniancohort AT iuliangoidescu umbilicalcordbiometryandfetalabdominalskinfoldassessmentaspotentialbiomarkersforfetalmacrosomiainagestationaldiabetesromaniancohort AT danielmuresan umbilicalcordbiometryandfetalabdominalskinfoldassessmentaspotentialbiomarkersforfetalmacrosomiainagestationaldiabetesromaniancohort AT florinstamatian umbilicalcordbiometryandfetalabdominalskinfoldassessmentaspotentialbiomarkersforfetalmacrosomiainagestationaldiabetesromaniancohort |