Senescent cells limit p53 activity via multiple mechanisms to remain viable
To develop therapeutics that selectively eliminate pathological senescent cells it is important to understand their survival mechanisms. Here, the authors show that senescent cells manage to survive by keeping p53 activity in check through multiple mechanisms, including inhibitory mechanisms that in...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31239-x |
| _version_ | 1818234083484893184 |
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| author | Ines Sturmlechner Chance C. Sine Karthik B. Jeganathan Cheng Zhang Raul O. Fierro Velasco Darren J. Baker Hu Li Jan M. van Deursen |
| author_facet | Ines Sturmlechner Chance C. Sine Karthik B. Jeganathan Cheng Zhang Raul O. Fierro Velasco Darren J. Baker Hu Li Jan M. van Deursen |
| author_sort | Ines Sturmlechner |
| collection | DOAJ |
| description | To develop therapeutics that selectively eliminate pathological senescent cells it is important to understand their survival mechanisms. Here, the authors show that senescent cells manage to survive by keeping p53 activity in check through multiple mechanisms, including inhibitory mechanisms that involve p53 binding to ribonucleases. |
| first_indexed | 2024-12-12T11:32:26Z |
| format | Article |
| id | doaj.art-acbe3fbfd0cd4e49ada168a6fd190c50 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-12T11:32:26Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-acbe3fbfd0cd4e49ada168a6fd190c502022-12-22T00:25:44ZengNature PortfolioNature Communications2041-17232022-06-0113111410.1038/s41467-022-31239-xSenescent cells limit p53 activity via multiple mechanisms to remain viableInes Sturmlechner0Chance C. Sine1Karthik B. Jeganathan2Cheng Zhang3Raul O. Fierro Velasco4Darren J. Baker5Hu Li6Jan M. van Deursen7Department of Pediatric and Adolescent Medicine, Mayo ClinicDepartment of Pediatric and Adolescent Medicine, Mayo ClinicDepartment of Pediatric and Adolescent Medicine, Mayo ClinicDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo ClinicDepartment of Pediatric and Adolescent Medicine, Mayo ClinicDepartment of Pediatric and Adolescent Medicine, Mayo ClinicDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo ClinicDepartment of Pediatric and Adolescent Medicine, Mayo ClinicTo develop therapeutics that selectively eliminate pathological senescent cells it is important to understand their survival mechanisms. Here, the authors show that senescent cells manage to survive by keeping p53 activity in check through multiple mechanisms, including inhibitory mechanisms that involve p53 binding to ribonucleases.https://doi.org/10.1038/s41467-022-31239-x |
| spellingShingle | Ines Sturmlechner Chance C. Sine Karthik B. Jeganathan Cheng Zhang Raul O. Fierro Velasco Darren J. Baker Hu Li Jan M. van Deursen Senescent cells limit p53 activity via multiple mechanisms to remain viable Nature Communications |
| title | Senescent cells limit p53 activity via multiple mechanisms to remain viable |
| title_full | Senescent cells limit p53 activity via multiple mechanisms to remain viable |
| title_fullStr | Senescent cells limit p53 activity via multiple mechanisms to remain viable |
| title_full_unstemmed | Senescent cells limit p53 activity via multiple mechanisms to remain viable |
| title_short | Senescent cells limit p53 activity via multiple mechanisms to remain viable |
| title_sort | senescent cells limit p53 activity via multiple mechanisms to remain viable |
| url | https://doi.org/10.1038/s41467-022-31239-x |
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