<it>GExplore</it>: a web server for integrated queries of protein domains, gene expression and mutant phenotypes
<p>Abstract</p> <p>Background</p> <p>The majority of the genes even in well-studied multi-cellular model organisms have not been functionally characterized yet. Mining the numerous genome wide data sets related to protein function to retrieve potential candidate genes f...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-11-01
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| Series: | BMC Genomics |
| Online Access: | http://www.biomedcentral.com/1471-2164/10/529 |
| _version_ | 1818757205941288960 |
|---|---|
| author | Chen Nansheng Ng Man-Ping Hutter Harald |
| author_facet | Chen Nansheng Ng Man-Ping Hutter Harald |
| author_sort | Chen Nansheng |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The majority of the genes even in well-studied multi-cellular model organisms have not been functionally characterized yet. Mining the numerous genome wide data sets related to protein function to retrieve potential candidate genes for a particular biological process remains a challenge.</p> <p>Description</p> <p>GExplore has been developed to provide a user-friendly database interface for data mining at the gene expression/protein function level to help in hypothesis development and experiment design. It supports combinatorial searches for proteins with certain domains, tissue- or developmental stage-specific expression patterns, and mutant phenotypes. GExplore operates on a stand-alone database and has fast response times, which is essential for exploratory searches. The interface is not only user-friendly, but also modular so that it accommodates additional data sets in the future.</p> <p>Conclusion</p> <p>GExplore is an online database for quick mining of data related to gene and protein function, providing a multi-gene display of data sets related to the domain composition of proteins as well as expression and phenotype data. GExplore is publicly available at: <url>http://genome.sfu.ca/gexplore/</url></p> |
| first_indexed | 2024-12-18T06:07:15Z |
| format | Article |
| id | doaj.art-acc08e52c08c42d6825a13d0ffc16bff |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-12-18T06:07:15Z |
| publishDate | 2009-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj.art-acc08e52c08c42d6825a13d0ffc16bff2022-12-21T21:18:31ZengBMCBMC Genomics1471-21642009-11-0110152910.1186/1471-2164-10-529<it>GExplore</it>: a web server for integrated queries of protein domains, gene expression and mutant phenotypesChen NanshengNg Man-PingHutter Harald<p>Abstract</p> <p>Background</p> <p>The majority of the genes even in well-studied multi-cellular model organisms have not been functionally characterized yet. Mining the numerous genome wide data sets related to protein function to retrieve potential candidate genes for a particular biological process remains a challenge.</p> <p>Description</p> <p>GExplore has been developed to provide a user-friendly database interface for data mining at the gene expression/protein function level to help in hypothesis development and experiment design. It supports combinatorial searches for proteins with certain domains, tissue- or developmental stage-specific expression patterns, and mutant phenotypes. GExplore operates on a stand-alone database and has fast response times, which is essential for exploratory searches. The interface is not only user-friendly, but also modular so that it accommodates additional data sets in the future.</p> <p>Conclusion</p> <p>GExplore is an online database for quick mining of data related to gene and protein function, providing a multi-gene display of data sets related to the domain composition of proteins as well as expression and phenotype data. GExplore is publicly available at: <url>http://genome.sfu.ca/gexplore/</url></p>http://www.biomedcentral.com/1471-2164/10/529 |
| spellingShingle | Chen Nansheng Ng Man-Ping Hutter Harald <it>GExplore</it>: a web server for integrated queries of protein domains, gene expression and mutant phenotypes BMC Genomics |
| title | <it>GExplore</it>: a web server for integrated queries of protein domains, gene expression and mutant phenotypes |
| title_full | <it>GExplore</it>: a web server for integrated queries of protein domains, gene expression and mutant phenotypes |
| title_fullStr | <it>GExplore</it>: a web server for integrated queries of protein domains, gene expression and mutant phenotypes |
| title_full_unstemmed | <it>GExplore</it>: a web server for integrated queries of protein domains, gene expression and mutant phenotypes |
| title_short | <it>GExplore</it>: a web server for integrated queries of protein domains, gene expression and mutant phenotypes |
| title_sort | it gexplore it a web server for integrated queries of protein domains gene expression and mutant phenotypes |
| url | http://www.biomedcentral.com/1471-2164/10/529 |
| work_keys_str_mv | AT chennansheng itgexploreitawebserverforintegratedqueriesofproteindomainsgeneexpressionandmutantphenotypes AT ngmanping itgexploreitawebserverforintegratedqueriesofproteindomainsgeneexpressionandmutantphenotypes AT hutterharald itgexploreitawebserverforintegratedqueriesofproteindomainsgeneexpressionandmutantphenotypes |