Enantioselective Microbial Reduction with Baker's Yeast on an Industrial Scale
Microbial synthesis is an important contribution to Green Chemistry and production-integrated environmental protection. The example of baker's yeast is used to demonstrate how microorganisms can be versatile reagents for asymmetric synthesis and how microbial technologies can be altern...
| Main Authors: | , |
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
2000-09-01
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| Series: | CHIMIA |
| Subjects: | |
| Online Access: | https://chimia.ch/chimia/article/view/3273 |
| _version_ | 1818282408490827776 |
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| author | Martin Bertau Martin Bürli |
| author_facet | Martin Bertau Martin Bürli |
| author_sort | Martin Bertau |
| collection | DOAJ |
| description |
Microbial synthesis is an important contribution to Green Chemistry and production-integrated environmental protection. The example of baker's yeast is used to demonstrate how microorganisms can be versatile reagents for asymmetric synthesis and how microbial technologies can be alternatives
and complements to catalytic processes. The commercial viability of enantioselective microbial processes on an industrial scale is shown with the examples of (S)-3-hydroxybutyric acid ethylester (1), (2S,5S)-hexanediol (2) and (1R,2S)-cis-2-hydroxycyclohexane
carboxylic acid ethylester (3). The investigation of several competing enzymatic pathways in the living cells during the reduction reaction allows the process to be controlled and makes this technology applicable for the large-scale commercial synthesis of 3.
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| first_indexed | 2024-12-13T00:20:32Z |
| format | Article |
| id | doaj.art-acc0ea0ee12e444295a56091918f2b4e |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-12-13T00:20:32Z |
| publishDate | 2000-09-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-acc0ea0ee12e444295a56091918f2b4e2022-12-22T00:05:36ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242000-09-01549Enantioselective Microbial Reduction with Baker's Yeast on an Industrial ScaleMartin BertauMartin Bürli Microbial synthesis is an important contribution to Green Chemistry and production-integrated environmental protection. The example of baker's yeast is used to demonstrate how microorganisms can be versatile reagents for asymmetric synthesis and how microbial technologies can be alternatives and complements to catalytic processes. The commercial viability of enantioselective microbial processes on an industrial scale is shown with the examples of (S)-3-hydroxybutyric acid ethylester (1), (2S,5S)-hexanediol (2) and (1R,2S)-cis-2-hydroxycyclohexane carboxylic acid ethylester (3). The investigation of several competing enzymatic pathways in the living cells during the reduction reaction allows the process to be controlled and makes this technology applicable for the large-scale commercial synthesis of 3. https://chimia.ch/chimia/article/view/3273Baker's yeastChiral pharmaceutical intermediatesCommercial chiral biosynthesisGreen chemistryMicrobial reduction |
| spellingShingle | Martin Bertau Martin Bürli Enantioselective Microbial Reduction with Baker's Yeast on an Industrial Scale CHIMIA Baker's yeast Chiral pharmaceutical intermediates Commercial chiral biosynthesis Green chemistry Microbial reduction |
| title | Enantioselective Microbial Reduction with Baker's Yeast on an Industrial Scale |
| title_full | Enantioselective Microbial Reduction with Baker's Yeast on an Industrial Scale |
| title_fullStr | Enantioselective Microbial Reduction with Baker's Yeast on an Industrial Scale |
| title_full_unstemmed | Enantioselective Microbial Reduction with Baker's Yeast on an Industrial Scale |
| title_short | Enantioselective Microbial Reduction with Baker's Yeast on an Industrial Scale |
| title_sort | enantioselective microbial reduction with baker s yeast on an industrial scale |
| topic | Baker's yeast Chiral pharmaceutical intermediates Commercial chiral biosynthesis Green chemistry Microbial reduction |
| url | https://chimia.ch/chimia/article/view/3273 |
| work_keys_str_mv | AT martinbertau enantioselectivemicrobialreductionwithbakersyeastonanindustrialscale AT martinburli enantioselectivemicrobialreductionwithbakersyeastonanindustrialscale |