Association of Gut Microbiome Dysbiosis with Neurodegeneration: Can Gut Microbe-Modifying Diet Prevent or Alleviate the Symptoms of Neurodegenerative Diseases?
The central nervous system was classically perceived as anatomically and functionally independent from the other visceral organs. But in recent decades, compelling evidence has led the scientific community to place a greater emphasis on the role of gut microbes on the brain. Pathological observation...
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MDPI AG
2021-07-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/11/7/698 |
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| author | Li Yang Tan Xin Yi Yeo Han-Gyu Bae Delia Pei Shan Lee Roger C. Ho Jung Eun Kim Dong-Gyu Jo Sangyong Jung |
| author_facet | Li Yang Tan Xin Yi Yeo Han-Gyu Bae Delia Pei Shan Lee Roger C. Ho Jung Eun Kim Dong-Gyu Jo Sangyong Jung |
| author_sort | Li Yang Tan |
| collection | DOAJ |
| description | The central nervous system was classically perceived as anatomically and functionally independent from the other visceral organs. But in recent decades, compelling evidence has led the scientific community to place a greater emphasis on the role of gut microbes on the brain. Pathological observations and early gastrointestinal symptoms highlighted that gut dysbiosis likely precedes the onset of cognitive deficits in Alzheimer’s disease (AD) and Parkinson’s disease (PD) patients. The delicate balance in the number and functions of pathogenic microbes and alternative probiotic populations is critical in the modulation of systemic inflammation and neuronal health. However, there is limited success in restoring healthy microbial biodiversity in AD and PD patients with general probiotics interventions and fecal microbial therapies. Fortunately, the gut microflora is susceptible to long-term extrinsic influences such as lifestyle and dietary choices, providing opportunities for treatment through comparatively individual-specific control of human behavior. In this review, we examine the impact of restrictive diets on the gut microbiome populations associated with AD and PD. The overall evidence presented supports that gut dysbiosis is a plausible prelude to disease onset, and early dietary interventions are likely beneficial for the prevention and treatment of progressive neurodegenerative diseases. |
| first_indexed | 2024-03-10T09:34:34Z |
| format | Article |
| id | doaj.art-acc14e35ad9644abbd008f54f4dbe2e4 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T09:34:34Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-acc14e35ad9644abbd008f54f4dbe2e42023-11-22T04:13:22ZengMDPI AGLife2075-17292021-07-0111769810.3390/life11070698Association of Gut Microbiome Dysbiosis with Neurodegeneration: Can Gut Microbe-Modifying Diet Prevent or Alleviate the Symptoms of Neurodegenerative Diseases?Li Yang Tan0Xin Yi Yeo1Han-Gyu Bae2Delia Pei Shan Lee3Roger C. Ho4Jung Eun Kim5Dong-Gyu Jo6Sangyong Jung7Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore 138667, SingaporeInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore 138667, SingaporeSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, KoreaDepartment of Food Science and Technology, Faculty of Science, National University of Singapore, Singapore 117542, SingaporeDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, SingaporeDepartment of Food Science and Technology, Faculty of Science, National University of Singapore, Singapore 117542, SingaporeSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, KoreaInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore 138667, SingaporeThe central nervous system was classically perceived as anatomically and functionally independent from the other visceral organs. But in recent decades, compelling evidence has led the scientific community to place a greater emphasis on the role of gut microbes on the brain. Pathological observations and early gastrointestinal symptoms highlighted that gut dysbiosis likely precedes the onset of cognitive deficits in Alzheimer’s disease (AD) and Parkinson’s disease (PD) patients. The delicate balance in the number and functions of pathogenic microbes and alternative probiotic populations is critical in the modulation of systemic inflammation and neuronal health. However, there is limited success in restoring healthy microbial biodiversity in AD and PD patients with general probiotics interventions and fecal microbial therapies. Fortunately, the gut microflora is susceptible to long-term extrinsic influences such as lifestyle and dietary choices, providing opportunities for treatment through comparatively individual-specific control of human behavior. In this review, we examine the impact of restrictive diets on the gut microbiome populations associated with AD and PD. The overall evidence presented supports that gut dysbiosis is a plausible prelude to disease onset, and early dietary interventions are likely beneficial for the prevention and treatment of progressive neurodegenerative diseases.https://www.mdpi.com/2075-1729/11/7/698gut microbiomegut–brain axisneurodegenerative diseaseprebiotics foods |
| spellingShingle | Li Yang Tan Xin Yi Yeo Han-Gyu Bae Delia Pei Shan Lee Roger C. Ho Jung Eun Kim Dong-Gyu Jo Sangyong Jung Association of Gut Microbiome Dysbiosis with Neurodegeneration: Can Gut Microbe-Modifying Diet Prevent or Alleviate the Symptoms of Neurodegenerative Diseases? Life gut microbiome gut–brain axis neurodegenerative disease prebiotics foods |
| title | Association of Gut Microbiome Dysbiosis with Neurodegeneration: Can Gut Microbe-Modifying Diet Prevent or Alleviate the Symptoms of Neurodegenerative Diseases? |
| title_full | Association of Gut Microbiome Dysbiosis with Neurodegeneration: Can Gut Microbe-Modifying Diet Prevent or Alleviate the Symptoms of Neurodegenerative Diseases? |
| title_fullStr | Association of Gut Microbiome Dysbiosis with Neurodegeneration: Can Gut Microbe-Modifying Diet Prevent or Alleviate the Symptoms of Neurodegenerative Diseases? |
| title_full_unstemmed | Association of Gut Microbiome Dysbiosis with Neurodegeneration: Can Gut Microbe-Modifying Diet Prevent or Alleviate the Symptoms of Neurodegenerative Diseases? |
| title_short | Association of Gut Microbiome Dysbiosis with Neurodegeneration: Can Gut Microbe-Modifying Diet Prevent or Alleviate the Symptoms of Neurodegenerative Diseases? |
| title_sort | association of gut microbiome dysbiosis with neurodegeneration can gut microbe modifying diet prevent or alleviate the symptoms of neurodegenerative diseases |
| topic | gut microbiome gut–brain axis neurodegenerative disease prebiotics foods |
| url | https://www.mdpi.com/2075-1729/11/7/698 |
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