Sarcoma as Second Cancer in a Childhood Cancer Survivor: Case Report, Large Population Analysis and Literature Review
The majority of pediatric patients are cured of their primary cancer with current advanced developments in pediatric cancer therapy. However, survivors often experience long-term complications from therapies for primary cancer. The delayed mortality rate has been decreasing with the effort to reduce...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/56/5/224 |
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| author | Thinh H. Nguyen Monish Ram Makena Siddhartha Yavvari Maninder Kaur Teresia Pham Eduardo Urias Narendra Panapitiya Mohamad M. Al-Rahawan |
| author_facet | Thinh H. Nguyen Monish Ram Makena Siddhartha Yavvari Maninder Kaur Teresia Pham Eduardo Urias Narendra Panapitiya Mohamad M. Al-Rahawan |
| author_sort | Thinh H. Nguyen |
| collection | DOAJ |
| description | The majority of pediatric patients are cured of their primary cancer with current advanced developments in pediatric cancer therapy. However, survivors often experience long-term complications from therapies for primary cancer. The delayed mortality rate has been decreasing with the effort to reduce the therapeutic exposure of patients with pediatric cancers. Our study investigates the incidence of sarcoma as second cancer in pediatric cancer survivors. We present a 9-year-old male who survived embryonal hepatoblastoma diagnosed at 22 months of age. At 4.5 years of age, he presented with a non-metastatic primitive neuroectodermal tumor (PNET) of the left submandibular area. He has no evidence of recurrence of either cancer for 51 months after finishing all chemotherapy and radiotherapy. We used the Surveillance, Epidemiology, and End Results (SEER) database to identify the current rate of second sarcomas in pediatric cancer survivors. Our literature review and large population analysis emphasize the impact of sarcoma as a second malignancy and provide help to physicians caring for pediatric cancer survivors. |
| first_indexed | 2024-03-12T11:13:56Z |
| format | Article |
| id | doaj.art-acc31685a85347888d8d94ae8babaeb3 |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T11:13:56Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-acc31685a85347888d8d94ae8babaeb32023-09-02T02:26:58ZengMDPI AGMedicina1010-660X2020-05-015622422410.3390/medicina56050224Sarcoma as Second Cancer in a Childhood Cancer Survivor: Case Report, Large Population Analysis and Literature ReviewThinh H. Nguyen0Monish Ram Makena1Siddhartha Yavvari2Maninder Kaur3Teresia Pham4Eduardo Urias5Narendra Panapitiya6Mohamad M. Al-Rahawan7Department of Pediatrics, Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX 79430, USADepartment of Physiology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USADepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USADepartment of Pediatrics, Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX 79430, USADepartment of Pediatrics, Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX 79430, USADepartment of Pediatrics, Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX 79430, USADepartment of Pediatrics, Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX 79430, USADepartment of Pediatrics, Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX 79430, USAThe majority of pediatric patients are cured of their primary cancer with current advanced developments in pediatric cancer therapy. However, survivors often experience long-term complications from therapies for primary cancer. The delayed mortality rate has been decreasing with the effort to reduce the therapeutic exposure of patients with pediatric cancers. Our study investigates the incidence of sarcoma as second cancer in pediatric cancer survivors. We present a 9-year-old male who survived embryonal hepatoblastoma diagnosed at 22 months of age. At 4.5 years of age, he presented with a non-metastatic primitive neuroectodermal tumor (PNET) of the left submandibular area. He has no evidence of recurrence of either cancer for 51 months after finishing all chemotherapy and radiotherapy. We used the Surveillance, Epidemiology, and End Results (SEER) database to identify the current rate of second sarcomas in pediatric cancer survivors. Our literature review and large population analysis emphasize the impact of sarcoma as a second malignancy and provide help to physicians caring for pediatric cancer survivors.https://www.mdpi.com/1010-660X/56/5/224sarcomasecond cancerhepatoblastomapediatricSEER |
| spellingShingle | Thinh H. Nguyen Monish Ram Makena Siddhartha Yavvari Maninder Kaur Teresia Pham Eduardo Urias Narendra Panapitiya Mohamad M. Al-Rahawan Sarcoma as Second Cancer in a Childhood Cancer Survivor: Case Report, Large Population Analysis and Literature Review Medicina sarcoma second cancer hepatoblastoma pediatric SEER |
| title | Sarcoma as Second Cancer in a Childhood Cancer Survivor: Case Report, Large Population Analysis and Literature Review |
| title_full | Sarcoma as Second Cancer in a Childhood Cancer Survivor: Case Report, Large Population Analysis and Literature Review |
| title_fullStr | Sarcoma as Second Cancer in a Childhood Cancer Survivor: Case Report, Large Population Analysis and Literature Review |
| title_full_unstemmed | Sarcoma as Second Cancer in a Childhood Cancer Survivor: Case Report, Large Population Analysis and Literature Review |
| title_short | Sarcoma as Second Cancer in a Childhood Cancer Survivor: Case Report, Large Population Analysis and Literature Review |
| title_sort | sarcoma as second cancer in a childhood cancer survivor case report large population analysis and literature review |
| topic | sarcoma second cancer hepatoblastoma pediatric SEER |
| url | https://www.mdpi.com/1010-660X/56/5/224 |
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