COVID-19-Associated Liver Injury

Daniel T Gildea,1 Stephanie M Woo,2 Corinne E O’Connor,3 Amol S Rangnekar4 1Department of Internal Medicine, MedStar Georgetown University Hospital, Washington, DC, USA; 2Department of Gastroenterology, MedStar Georgetown University Hospital, Washington, DC, USA; 3Georgetown University School of Med...

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Main Authors: Gildea DT, Woo SM, O'Connor CE, Rangnekar AS
Format: Article
Language:English
Published: Dove Medical Press 2023-02-01
Series:Hepatic Medicine: Evidence and Research
Subjects:
Online Access:https://www.dovepress.com/covid-19-associated-liver-injury-peer-reviewed-fulltext-article-HMER
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author Gildea DT
Woo SM
O'Connor CE
Rangnekar AS
author_facet Gildea DT
Woo SM
O'Connor CE
Rangnekar AS
author_sort Gildea DT
collection DOAJ
description Daniel T Gildea,1 Stephanie M Woo,2 Corinne E O’Connor,3 Amol S Rangnekar4 1Department of Internal Medicine, MedStar Georgetown University Hospital, Washington, DC, USA; 2Department of Gastroenterology, MedStar Georgetown University Hospital, Washington, DC, USA; 3Georgetown University School of Medicine, Washington, DC, USA; 4MedStar Georgetown Transplant Institute, MedStar Georgetown University Hospital, Washington, DC, USACorrespondence: Daniel T Gildea, Tel +1 302-985-7777, Email daniel.gildea@medstar.netAbstract: This review analyzes data regarding liver injury associated with COVID-19 infection. We discuss reported effects on the liver from both COVID-19 and COVID-19 treatment as well as pathophysiology, review the potential role of drug-induced liver injury as an etiology of COVID-19-associated liver injury, and touch on other reports of significant outcomes including COVID-19 cholangiopathy and autoimmune hepatitis. Finally, we review the implications of COVID-19 infection in liver transplant recipients.Keywords: COVID-19, cholangiopathy, DILI, hepatitis, transplant, liver
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spelling doaj.art-acc39c0bb00a4735b39e5a4fbd17d8732023-02-21T18:00:14ZengDove Medical PressHepatic Medicine: Evidence and Research1179-15352023-02-01Volume 151981783COVID-19-Associated Liver InjuryGildea DTWoo SMO'Connor CERangnekar ASDaniel T Gildea,1 Stephanie M Woo,2 Corinne E O’Connor,3 Amol S Rangnekar4 1Department of Internal Medicine, MedStar Georgetown University Hospital, Washington, DC, USA; 2Department of Gastroenterology, MedStar Georgetown University Hospital, Washington, DC, USA; 3Georgetown University School of Medicine, Washington, DC, USA; 4MedStar Georgetown Transplant Institute, MedStar Georgetown University Hospital, Washington, DC, USACorrespondence: Daniel T Gildea, Tel +1 302-985-7777, Email daniel.gildea@medstar.netAbstract: This review analyzes data regarding liver injury associated with COVID-19 infection. We discuss reported effects on the liver from both COVID-19 and COVID-19 treatment as well as pathophysiology, review the potential role of drug-induced liver injury as an etiology of COVID-19-associated liver injury, and touch on other reports of significant outcomes including COVID-19 cholangiopathy and autoimmune hepatitis. Finally, we review the implications of COVID-19 infection in liver transplant recipients.Keywords: COVID-19, cholangiopathy, DILI, hepatitis, transplant, liverhttps://www.dovepress.com/covid-19-associated-liver-injury-peer-reviewed-fulltext-article-HMERkeywords: covid-19cholangiopathydilihepatitistransplantliver
spellingShingle Gildea DT
Woo SM
O'Connor CE
Rangnekar AS
COVID-19-Associated Liver Injury
Hepatic Medicine: Evidence and Research
keywords: covid-19
cholangiopathy
dili
hepatitis
transplant
liver
title COVID-19-Associated Liver Injury
title_full COVID-19-Associated Liver Injury
title_fullStr COVID-19-Associated Liver Injury
title_full_unstemmed COVID-19-Associated Liver Injury
title_short COVID-19-Associated Liver Injury
title_sort covid 19 associated liver injury
topic keywords: covid-19
cholangiopathy
dili
hepatitis
transplant
liver
url https://www.dovepress.com/covid-19-associated-liver-injury-peer-reviewed-fulltext-article-HMER
work_keys_str_mv AT gildeadt covid19associatedliverinjury
AT woosm covid19associatedliverinjury
AT oconnorce covid19associatedliverinjury
AT rangnekaras covid19associatedliverinjury