Assessing the efficacy and safety of autologous bone marrow injections in treating delayed union of long bone fractures: A retrospective analysis
Background: Delayed union in long bone fractures poses a significant clinical challenge, necessitating effective treatment solutions. The urgency for novel and effective treatment modalities is ever-increasing, especially considering the prevalence and complications associated with delayed union....
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2023-12-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/58635 |
| _version_ | 1797432046861156352 |
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| author | Suresh Katakam Boda Neeraja Suguru Ravali Srinivas Bachu |
| author_facet | Suresh Katakam Boda Neeraja Suguru Ravali Srinivas Bachu |
| author_sort | Suresh Katakam |
| collection | DOAJ |
| description | Background: Delayed union in long bone fractures poses a significant clinical challenge, necessitating effective treatment solutions. The urgency for novel and effective treatment modalities is ever-increasing, especially considering the prevalence and complications associated with delayed union.
Aims and Objectives: This retrospective analysis aims to assess the safety and efficacy of autologous bone marrow injections in treating delayed union in a diverse cohort of individuals with long bone fractures.
Materials and Methods: The study includes 100 individuals aged 21–69 with varying fracture types. Fracture classifications comprised 40% closed fractures (n=40) and 60% open fractures (n=60). Notably, the femur had a higher prevalence of open fractures (n=30) than closed fractures (n=20). Tibia fractures demonstrated a similar propensity, with 25 open and 15 closed cases. Humerus fractures manifested an even distribution between open and closed categories (n=5 each), indicating their relative resilience to open fractures.
Results: Union was attained in 82 cases, with a mean union time of 7.4 weeks post-the-third bone marrow injection. The timeframe for the union varied widely, ranging from 4 to 17 weeks. In eight instances where bone marrow injections failed to achieve union, alternative treatment via bone grafting was necessary. No significant complications were reported; however, minor discomfort was experienced by 13% of the patients and was effectively managed with over-the-counter analgesics.
Conclusion: This retrospective analysis demonstrates the high efficacy and safety of autologous bone marrow injections in treating delayed union in long bones, making them a promising alternative treatment strategy with minimal complications. |
| first_indexed | 2024-03-09T09:54:36Z |
| format | Article |
| id | doaj.art-acc4ec503847484784e8c45df7938413 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-03-09T09:54:36Z |
| publishDate | 2023-12-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-acc4ec503847484784e8c45df79384132023-12-01T23:54:00ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762023-12-011412159164https://doi.org/10.3126/ajms.v14i12.58635Assessing the efficacy and safety of autologous bone marrow injections in treating delayed union of long bone fractures: A retrospective analysisSuresh Katakam 0https://orcid.org/0009-0004-0492-3029Boda Neeraja 1https://orcid.org/0009-0006-4956-6875Suguru Ravali 2https://orcid.org/0009-0004-5005-8363Srinivas Bachu 3https://orcid.org/0009-0000-2989-3066Assistant Professor, Department of Orthopedics, Government Medical College and General Hospital, Suryapet, Telangana, India Assistant Professor, Department of Orthopedics, Government Medical College and General Hospital, Suryapet, Telangana, India Assistant Professor, Department of Orthopedics, Government Medical College and General Hospital, Suryapet, Telangana, India Professor, Department of Orthopedics, Government Medical College and General Hospital, Suryapet, Telangana, India Background: Delayed union in long bone fractures poses a significant clinical challenge, necessitating effective treatment solutions. The urgency for novel and effective treatment modalities is ever-increasing, especially considering the prevalence and complications associated with delayed union. Aims and Objectives: This retrospective analysis aims to assess the safety and efficacy of autologous bone marrow injections in treating delayed union in a diverse cohort of individuals with long bone fractures. Materials and Methods: The study includes 100 individuals aged 21–69 with varying fracture types. Fracture classifications comprised 40% closed fractures (n=40) and 60% open fractures (n=60). Notably, the femur had a higher prevalence of open fractures (n=30) than closed fractures (n=20). Tibia fractures demonstrated a similar propensity, with 25 open and 15 closed cases. Humerus fractures manifested an even distribution between open and closed categories (n=5 each), indicating their relative resilience to open fractures. Results: Union was attained in 82 cases, with a mean union time of 7.4 weeks post-the-third bone marrow injection. The timeframe for the union varied widely, ranging from 4 to 17 weeks. In eight instances where bone marrow injections failed to achieve union, alternative treatment via bone grafting was necessary. No significant complications were reported; however, minor discomfort was experienced by 13% of the patients and was effectively managed with over-the-counter analgesics. Conclusion: This retrospective analysis demonstrates the high efficacy and safety of autologous bone marrow injections in treating delayed union in long bones, making them a promising alternative treatment strategy with minimal complications.https://www.nepjol.info/index.php/AJMS/article/view/58635delayed union; long bone fractures; bone marrow injection; efficacy; safety; fracture union; closed fractures |
| spellingShingle | Suresh Katakam Boda Neeraja Suguru Ravali Srinivas Bachu Assessing the efficacy and safety of autologous bone marrow injections in treating delayed union of long bone fractures: A retrospective analysis Asian Journal of Medical Sciences delayed union; long bone fractures; bone marrow injection; efficacy; safety; fracture union; closed fractures |
| title | Assessing the efficacy and safety of autologous bone marrow injections in treating delayed union of long bone fractures: A retrospective analysis |
| title_full | Assessing the efficacy and safety of autologous bone marrow injections in treating delayed union of long bone fractures: A retrospective analysis |
| title_fullStr | Assessing the efficacy and safety of autologous bone marrow injections in treating delayed union of long bone fractures: A retrospective analysis |
| title_full_unstemmed | Assessing the efficacy and safety of autologous bone marrow injections in treating delayed union of long bone fractures: A retrospective analysis |
| title_short | Assessing the efficacy and safety of autologous bone marrow injections in treating delayed union of long bone fractures: A retrospective analysis |
| title_sort | assessing the efficacy and safety of autologous bone marrow injections in treating delayed union of long bone fractures a retrospective analysis |
| topic | delayed union; long bone fractures; bone marrow injection; efficacy; safety; fracture union; closed fractures |
| url | https://www.nepjol.info/index.php/AJMS/article/view/58635 |
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