Zinc Supplementation Dosage Variations to Metallothionein Protein Level of Rattus Norvegicus
Zinc is an essential trace element involving in the activity of more than 300 enzymes and proteins of human body. One important role of zinc is to improve metallothionein protein binding heavy metals and functioning as heavy metal detoxification facilities. This research discusses the effect of zinc...
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| Format: | Article |
| Language: | English |
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Diponegoro University
2013-09-01
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| Series: | International Journal of Science and Engineering |
| Subjects: | |
| Online Access: | https://ejournal.undip.ac.id/index.php/ijse/article/view/5471 |
| _version_ | 1811247971757457408 |
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| author | Budi Santosa Hertanto Wahyu Subagyo Lisyani S Henna Rya Sunoko |
| author_facet | Budi Santosa Hertanto Wahyu Subagyo Lisyani S Henna Rya Sunoko |
| author_sort | Budi Santosa |
| collection | DOAJ |
| description | Zinc is an essential trace element involving in the activity of more than 300 enzymes and proteins of human body. One important role of zinc is to improve metallothionein protein binding heavy metals and functioning as heavy metal detoxification facilities. This research discusses the effect of zinc supplement on the improvement of metallothionein protein level. The in vivo test involving 28 rats categorized in 4 groups was performed. The experiments used randomized post test control group design. The 3 groups were daily supplemented by zinc in th concentration of 0.2 mg, 0.4 mg, and 0.8 mg. Whereas, the last group was let without zinc treatment. As an indicator the metallothionein protein level was checked after three weeks. The data was then evaluated by Anova an Bonferroni test in order to know the signicant of protein level difference among the groups.
The result showed that the average of metallothionein protein level improved by increasing zinc suppplement with the 0.95 ±0.20; 1.28 ±0.19; 1.39 ±0.09; 1.91 ±0.3 ng/ml metallothionein per 0, 0,2, 0,4, 0,8.mg zinc added. Based on the ANOVA and Bonferroni test, indicated that the improvement was significant as shown with p value of 0.00 |
| first_indexed | 2024-04-12T15:18:43Z |
| format | Article |
| id | doaj.art-acc5be8297da46d8a8dbdc06c3273fc2 |
| institution | Directory Open Access Journal |
| issn | 2086-5023 2302-5743 |
| language | English |
| last_indexed | 2024-04-12T15:18:43Z |
| publishDate | 2013-09-01 |
| publisher | Diponegoro University |
| record_format | Article |
| series | International Journal of Science and Engineering |
| spelling | doaj.art-acc5be8297da46d8a8dbdc06c3273fc22022-12-22T03:27:32ZengDiponegoro UniversityInternational Journal of Science and Engineering2086-50232302-57432013-09-0152151710.12777/ijse.5.2.15-174840Zinc Supplementation Dosage Variations to Metallothionein Protein Level of Rattus NorvegicusBudi Santosa0Hertanto Wahyu SubagyoLisyani SHenna Rya SunokoFaculty of Nursing and Health Muhammadiyah University, SemarangZinc is an essential trace element involving in the activity of more than 300 enzymes and proteins of human body. One important role of zinc is to improve metallothionein protein binding heavy metals and functioning as heavy metal detoxification facilities. This research discusses the effect of zinc supplement on the improvement of metallothionein protein level. The in vivo test involving 28 rats categorized in 4 groups was performed. The experiments used randomized post test control group design. The 3 groups were daily supplemented by zinc in th concentration of 0.2 mg, 0.4 mg, and 0.8 mg. Whereas, the last group was let without zinc treatment. As an indicator the metallothionein protein level was checked after three weeks. The data was then evaluated by Anova an Bonferroni test in order to know the signicant of protein level difference among the groups. The result showed that the average of metallothionein protein level improved by increasing zinc suppplement with the 0.95 ±0.20; 1.28 ±0.19; 1.39 ±0.09; 1.91 ±0.3 ng/ml metallothionein per 0, 0,2, 0,4, 0,8.mg zinc added. Based on the ANOVA and Bonferroni test, indicated that the improvement was significant as shown with p value of 0.00https://ejournal.undip.ac.id/index.php/ijse/article/view/5471Zinc supplementation, metallothionein |
| spellingShingle | Budi Santosa Hertanto Wahyu Subagyo Lisyani S Henna Rya Sunoko Zinc Supplementation Dosage Variations to Metallothionein Protein Level of Rattus Norvegicus International Journal of Science and Engineering Zinc supplementation, metallothionein |
| title | Zinc Supplementation Dosage Variations to Metallothionein Protein Level of Rattus Norvegicus |
| title_full | Zinc Supplementation Dosage Variations to Metallothionein Protein Level of Rattus Norvegicus |
| title_fullStr | Zinc Supplementation Dosage Variations to Metallothionein Protein Level of Rattus Norvegicus |
| title_full_unstemmed | Zinc Supplementation Dosage Variations to Metallothionein Protein Level of Rattus Norvegicus |
| title_short | Zinc Supplementation Dosage Variations to Metallothionein Protein Level of Rattus Norvegicus |
| title_sort | zinc supplementation dosage variations to metallothionein protein level of rattus norvegicus |
| topic | Zinc supplementation, metallothionein |
| url | https://ejournal.undip.ac.id/index.php/ijse/article/view/5471 |
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