HLA Pharmacogenetic Markers of Drug Hypersensitivity in a Thai Population
Severe cutaneous adverse drug reactions (SCARs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reactions with eosinophilia and systemic symptoms (DRESS) are potentially life-threatening cutaneous reactions caused by several drugs. Recently, a number of genes enc...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-08-01
|
| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fgene.2018.00277/full |
| _version_ | 1819095418448904192 |
|---|---|
| author | Nontaya Nakkam Parinya Konyoung Sirimas Kanjanawart Niwat Saksit Thachanan Kongpan Kanyarat Khaeso Usanee Khunarkornsiri Areerat Dornsena Wongwiwat Tassaneeyakul Wichittra Tassaneeyakul |
| author_facet | Nontaya Nakkam Parinya Konyoung Sirimas Kanjanawart Niwat Saksit Thachanan Kongpan Kanyarat Khaeso Usanee Khunarkornsiri Areerat Dornsena Wongwiwat Tassaneeyakul Wichittra Tassaneeyakul |
| author_sort | Nontaya Nakkam |
| collection | DOAJ |
| description | Severe cutaneous adverse drug reactions (SCARs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reactions with eosinophilia and systemic symptoms (DRESS) are potentially life-threatening cutaneous reactions caused by several drugs. Recently, a number of genes encoding for human antigen presenting proteins, HLA alleles, have been discovered as valid pharmacogenetic markers for prediction of these life-threatening reactions. This study was aimed to determine the distribution of HLA alleles including the HLA class I and class II genes in 183 unrelated individuals of a Thai population using high resolution HLA genotyping in order to obtain 2-field data (4-digit resolution) and compare the frequencies of the HLA alleles that have been proposed as markers of SCARs with other ethnics. Results revealed a high prevalence of pharmacogenetic markers of drug-induced SCARs e.g., B*13:01 for dapsone; B*15:02 for carbamazepine and oxcarbazepine; B*58:01, A*33:03 and C*03:02 for allopurinol; C*08:01, C*14:02 and DRB1*12:02 for co-trimoxazole. Whereas, low prevalence of pharmacogenetic markers of SCARs induced by abacavir, B*57:01 and phenytoin, B*56:02/B*56:04 were noticed. The allele frequencies of B*13:01, B*15:02, and B*58:01 observed in a Thai population were significantly higher than those reported in Japanese and Caucasian populations. Similar to those observed in other Southeast Asian populations, low frequencies of A*31:01 and B*57:01 alleles were noted in the study population. Based on the frequencies of HLA pharmacogenetic markers, Thai and other Southeast Asian populations may at higher risk of drug-induced SCARs compared with Caucasian population. |
| first_indexed | 2024-12-21T23:42:59Z |
| format | Article |
| id | doaj.art-acc5fa5db7494492ab9255221751dfc0 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-21T23:42:59Z |
| publishDate | 2018-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-acc5fa5db7494492ab9255221751dfc02022-12-21T18:46:11ZengFrontiers Media S.A.Frontiers in Genetics1664-80212018-08-01910.3389/fgene.2018.00277394719HLA Pharmacogenetic Markers of Drug Hypersensitivity in a Thai PopulationNontaya Nakkam0Parinya Konyoung1Sirimas Kanjanawart2Niwat Saksit3Thachanan Kongpan4Kanyarat Khaeso5Usanee Khunarkornsiri6Areerat Dornsena7Wongwiwat Tassaneeyakul8Wichittra Tassaneeyakul9Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandPharmacy Unit, Udon Thani Hospital, Udon Thani, ThailandDepartment of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandSchool of Pharmaceutical Sciences, University of Phayao, Phayao, ThailandDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandDepartment of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandPharmacy Unit, Udon Thani Hospital, Udon Thani, ThailandDepartment of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandFaculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, ThailandDepartment of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandSevere cutaneous adverse drug reactions (SCARs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reactions with eosinophilia and systemic symptoms (DRESS) are potentially life-threatening cutaneous reactions caused by several drugs. Recently, a number of genes encoding for human antigen presenting proteins, HLA alleles, have been discovered as valid pharmacogenetic markers for prediction of these life-threatening reactions. This study was aimed to determine the distribution of HLA alleles including the HLA class I and class II genes in 183 unrelated individuals of a Thai population using high resolution HLA genotyping in order to obtain 2-field data (4-digit resolution) and compare the frequencies of the HLA alleles that have been proposed as markers of SCARs with other ethnics. Results revealed a high prevalence of pharmacogenetic markers of drug-induced SCARs e.g., B*13:01 for dapsone; B*15:02 for carbamazepine and oxcarbazepine; B*58:01, A*33:03 and C*03:02 for allopurinol; C*08:01, C*14:02 and DRB1*12:02 for co-trimoxazole. Whereas, low prevalence of pharmacogenetic markers of SCARs induced by abacavir, B*57:01 and phenytoin, B*56:02/B*56:04 were noticed. The allele frequencies of B*13:01, B*15:02, and B*58:01 observed in a Thai population were significantly higher than those reported in Japanese and Caucasian populations. Similar to those observed in other Southeast Asian populations, low frequencies of A*31:01 and B*57:01 alleles were noted in the study population. Based on the frequencies of HLA pharmacogenetic markers, Thai and other Southeast Asian populations may at higher risk of drug-induced SCARs compared with Caucasian population.https://www.frontiersin.org/article/10.3389/fgene.2018.00277/fullHLA allele frequencyhigh-resolutiondrug hypersensitivitygenetic markerThai |
| spellingShingle | Nontaya Nakkam Parinya Konyoung Sirimas Kanjanawart Niwat Saksit Thachanan Kongpan Kanyarat Khaeso Usanee Khunarkornsiri Areerat Dornsena Wongwiwat Tassaneeyakul Wichittra Tassaneeyakul HLA Pharmacogenetic Markers of Drug Hypersensitivity in a Thai Population Frontiers in Genetics HLA allele frequency high-resolution drug hypersensitivity genetic marker Thai |
| title | HLA Pharmacogenetic Markers of Drug Hypersensitivity in a Thai Population |
| title_full | HLA Pharmacogenetic Markers of Drug Hypersensitivity in a Thai Population |
| title_fullStr | HLA Pharmacogenetic Markers of Drug Hypersensitivity in a Thai Population |
| title_full_unstemmed | HLA Pharmacogenetic Markers of Drug Hypersensitivity in a Thai Population |
| title_short | HLA Pharmacogenetic Markers of Drug Hypersensitivity in a Thai Population |
| title_sort | hla pharmacogenetic markers of drug hypersensitivity in a thai population |
| topic | HLA allele frequency high-resolution drug hypersensitivity genetic marker Thai |
| url | https://www.frontiersin.org/article/10.3389/fgene.2018.00277/full |
| work_keys_str_mv | AT nontayanakkam hlapharmacogeneticmarkersofdrughypersensitivityinathaipopulation AT parinyakonyoung hlapharmacogeneticmarkersofdrughypersensitivityinathaipopulation AT sirimaskanjanawart hlapharmacogeneticmarkersofdrughypersensitivityinathaipopulation AT niwatsaksit hlapharmacogeneticmarkersofdrughypersensitivityinathaipopulation AT thachanankongpan hlapharmacogeneticmarkersofdrughypersensitivityinathaipopulation AT kanyaratkhaeso hlapharmacogeneticmarkersofdrughypersensitivityinathaipopulation AT usaneekhunarkornsiri hlapharmacogeneticmarkersofdrughypersensitivityinathaipopulation AT areeratdornsena hlapharmacogeneticmarkersofdrughypersensitivityinathaipopulation AT wongwiwattassaneeyakul hlapharmacogeneticmarkersofdrughypersensitivityinathaipopulation AT wichittratassaneeyakul hlapharmacogeneticmarkersofdrughypersensitivityinathaipopulation |