Simultaneous determination of seven bile acids to study the effect of ivermectin on their plasma levels in rat by UHPLC–MS/MS

Simultaneous determination of seven bile acids to study the effect of ivermectin on their plasma levels in rat by UHPLC–MS/MS

Abstract Bile acids (BAs) are considered to be important diagnostic biomarkers to understand the pathophysiology of hepatobiliary and metabolic diseases. BAs regulate lipid and glucose metabolism by binding to farnesoid X receptor (FXR). To date, there were no reports on the effect of an exogenous F...

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Bibliographic Details
Main Authors: T. V. Radhakrishna Mullapudi, Punna Rao Ravi, Ganapathi Thipparapu
Format: Article
Language:English
Published: SpringerOpen 2023-10-01
Series:Journal of Analytical Science and Technology
Subjects:
Bile acids
UHPLC–MS/MS
Method validation
Ivermectin
FXR ligands
Homeostasis
Online Access:https://doi.org/10.1186/s40543-023-00408-y

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