Multi-Omics Profiling to Assess Signaling Changes upon VHL Restoration and Identify Putative VHL Substrates in Clear Cell Renal Cell Carcinoma Cell Lines

Multi-Omics Profiling to Assess Signaling Changes upon VHL Restoration and Identify Putative VHL Substrates in Clear Cell Renal Cell Carcinoma Cell Lines

The inactivation of von Hippel–Lindau (VHL) is critical for clear cell renal cell carcinoma (ccRCC) and VHL syndrome. VHL loss leads to the stabilization of hypoxia-inducible factor α (HIFα) and other substrate proteins, which, together, drive various tumor-promoting pathways. There is inadequate mo...

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Bibliographic Details
Main Authors:	Xuechun Wang, Jin Hu, Yihao Fang, Yanbin Fu, Bing Liu, Chao Zhang, Shan Feng, Xin Lu
Format:	Article
Language:	English
Published:	MDPI AG 2022-01-01
Series:	Cells
Subjects:	von Hippel–Lindau VHL clear cell renal cell carcinoma ubiquitome E3 ubiquitin ligase TGFBI
Online Access:	https://www.mdpi.com/2073-4409/11/3/472

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