Impact of vitamin D on cognitive functions in healthy individuals: A systematic review in randomized controlled clinical trials
Various functions in the central nervous system, such as growth, development, and cognition can be influenced by vitamins and minerals, which are capable of helping to maintain brain health and function throughout life. Cognition is understood as the aspects related to knowledge, learning, and under...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Psychology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyg.2022.987203/full |
| _version_ | 1797893101592772608 |
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| author | Ana Beatriz Januário da Silva Ana Beatriz Januário da Silva Waleska Maria Almeida Barros Waleska Maria Almeida Barros Mayara Luclécia da Silva Mayara Luclécia da Silva José Maurício Lucas Silva José Maurício Lucas Silva Ana Patrícia da Silva Souza Ana Patrícia da Silva Souza Karollainy Gomes da Silva Karollainy Gomes da Silva Matheus Santos de Sousa Fernandes Antonietta Cláudia Barbosa da Fonseca Carneiro Ana Elisa Toscano Cláudia Jacques Lagranha Cláudia Jacques Lagranha |
| author_facet | Ana Beatriz Januário da Silva Ana Beatriz Januário da Silva Waleska Maria Almeida Barros Waleska Maria Almeida Barros Mayara Luclécia da Silva Mayara Luclécia da Silva José Maurício Lucas Silva José Maurício Lucas Silva Ana Patrícia da Silva Souza Ana Patrícia da Silva Souza Karollainy Gomes da Silva Karollainy Gomes da Silva Matheus Santos de Sousa Fernandes Antonietta Cláudia Barbosa da Fonseca Carneiro Ana Elisa Toscano Cláudia Jacques Lagranha Cláudia Jacques Lagranha |
| author_sort | Ana Beatriz Januário da Silva |
| collection | DOAJ |
| description | Various functions in the central nervous system, such as growth, development, and cognition can be influenced by vitamins and minerals, which are capable of helping to maintain brain health and function throughout life. Cognition is understood as the aspects related to knowledge, learning, and understanding, as well as the ability to develop these functions. A possible association between low levels of vit D and deficit in the performance of cognitive functions in healthy humans or with some pathological condition is discussed. Because of this, the present systematic review analyzed only randomized clinical trials carried out in healthy non-athlete adults about intellectual and/or mental processes involving cognitive functions to identify whether these individuals with different levels of vit D are capable of interfering with the performance of the cognitive function. To do so, we adopted the PRISMA method criteria and registered it in the PROSPERO database. The search was performed in PubMed (MEDLINE), PsycINFO, Science Direct, Scopus, and Web of Science databases, 2,167 records were identified. The 5 most frequent cognitive domains in the selected studies were: processing speed, attention, verbal learning/memory, executive function, and general cognitive functions. We found that there are positive changes in the following domains: verbal memory and verbal working memory, learning memory, attention, executive function, and also cognitive function in general. We highlight the following suggestions for improvements that vitamin D supplementation may promote in the cognitive domains of healthy adults: a) low doses between 400 and 600 IU/d seem to be more effective when compared to doses between 2,400 and 5,000 IU/d and b) food fortification and enrichment with vit D, need further studies, as they seem to be more or as effective as synthetic supplementation. We evident that there is a need for trials that evaluate the control of vit D levels for healthy adult individuals is important, as they have the potential to minimize health problems, especially those involved in the reduction of cognitive abilities. Thus, the development of more clinical trials to obtain satisfactory answers on this topic needs to be encouraged.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42021262413. |
| first_indexed | 2024-04-10T06:47:33Z |
| format | Article |
| id | doaj.art-acc74e8f32a24d7fb5a8316b962519b7 |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-04-10T06:47:33Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-acc74e8f32a24d7fb5a8316b962519b72023-02-28T10:10:06ZengFrontiers Media S.A.Frontiers in Psychology1664-10782022-11-011310.3389/fpsyg.2022.987203987203Impact of vitamin D on cognitive functions in healthy individuals: A systematic review in randomized controlled clinical trialsAna Beatriz Januário da Silva0Ana Beatriz Januário da Silva1Waleska Maria Almeida Barros2Waleska Maria Almeida Barros3Mayara Luclécia da Silva4Mayara Luclécia da Silva5José Maurício Lucas Silva6José Maurício Lucas Silva7Ana Patrícia da Silva Souza8Ana Patrícia da Silva Souza9Karollainy Gomes da Silva10Karollainy Gomes da Silva11Matheus Santos de Sousa Fernandes12Antonietta Cláudia Barbosa da Fonseca Carneiro13Ana Elisa Toscano14Cláudia Jacques Lagranha15Cláudia Jacques Lagranha16Programa de Pós-graduação em Neuropsiquiatria e Ciências do Comportamento, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Recife, PE, BrazilCentro Integrado de Tecnologias em Neurociência (CITENC), Centro Universitário Osman Lins (UNIFACOL), Vitória de Santo Antão, PE, BrazilPrograma de Pós-graduação em Neuropsiquiatria e Ciências do Comportamento, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Recife, PE, BrazilCentro Integrado de Tecnologias em Neurociência (CITENC), Centro Universitário Osman Lins (UNIFACOL), Vitória de Santo Antão, PE, BrazilCentro Integrado de Tecnologias em Neurociência (CITENC), Centro Universitário Osman Lins (UNIFACOL), Vitória de Santo Antão, PE, BrazilPrograma de Pós-graduação Multicêntrico em Ciências Fisiológicas, Centro Acadêmico de Vitória, Universidade Federal de Pernambuco, Vitória de Santo Antão, BrazilCentro Integrado de Tecnologias em Neurociência (CITENC), Centro Universitário Osman Lins (UNIFACOL), Vitória de Santo Antão, PE, BrazilPrograma de Pós-graduação Multicêntrico em Ciências Fisiológicas, Centro Acadêmico de Vitória, Universidade Federal de Pernambuco, Vitória de Santo Antão, BrazilPrograma de Pós-graduação em Neuropsiquiatria e Ciências do Comportamento, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Recife, PE, BrazilCentro Integrado de Tecnologias em Neurociência (CITENC), Centro Universitário Osman Lins (UNIFACOL), Vitória de Santo Antão, PE, BrazilPrograma de Pós-graduação em Neuropsiquiatria e Ciências do Comportamento, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Recife, PE, BrazilCentro Integrado de Tecnologias em Neurociência (CITENC), Centro Universitário Osman Lins (UNIFACOL), Vitória de Santo Antão, PE, BrazilPrograma de Pós-graduação em Neuropsiquiatria e Ciências do Comportamento, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Recife, PE, BrazilCentro Integrado de Tecnologias em Neurociência (CITENC), Centro Universitário Osman Lins (UNIFACOL), Vitória de Santo Antão, PE, BrazilCentro Acadêmico de Vitória, Universidade Federal de Pernambuco, Vitória de Santo Antão, BrazilPrograma de Pós-graduação em Neuropsiquiatria e Ciências do Comportamento, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Recife, PE, BrazilLaboratorio de Bioquimica Geral, Molecular e do Exercicio–Universidade Federal de Pernambuco, Centro Acadêmico de Vitória (CAV)—UFPE, Vitória de Santo Antão, PE, BrazilVarious functions in the central nervous system, such as growth, development, and cognition can be influenced by vitamins and minerals, which are capable of helping to maintain brain health and function throughout life. Cognition is understood as the aspects related to knowledge, learning, and understanding, as well as the ability to develop these functions. A possible association between low levels of vit D and deficit in the performance of cognitive functions in healthy humans or with some pathological condition is discussed. Because of this, the present systematic review analyzed only randomized clinical trials carried out in healthy non-athlete adults about intellectual and/or mental processes involving cognitive functions to identify whether these individuals with different levels of vit D are capable of interfering with the performance of the cognitive function. To do so, we adopted the PRISMA method criteria and registered it in the PROSPERO database. The search was performed in PubMed (MEDLINE), PsycINFO, Science Direct, Scopus, and Web of Science databases, 2,167 records were identified. The 5 most frequent cognitive domains in the selected studies were: processing speed, attention, verbal learning/memory, executive function, and general cognitive functions. We found that there are positive changes in the following domains: verbal memory and verbal working memory, learning memory, attention, executive function, and also cognitive function in general. We highlight the following suggestions for improvements that vitamin D supplementation may promote in the cognitive domains of healthy adults: a) low doses between 400 and 600 IU/d seem to be more effective when compared to doses between 2,400 and 5,000 IU/d and b) food fortification and enrichment with vit D, need further studies, as they seem to be more or as effective as synthetic supplementation. We evident that there is a need for trials that evaluate the control of vit D levels for healthy adult individuals is important, as they have the potential to minimize health problems, especially those involved in the reduction of cognitive abilities. Thus, the development of more clinical trials to obtain satisfactory answers on this topic needs to be encouraged.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42021262413.https://www.frontiersin.org/articles/10.3389/fpsyg.2022.987203/fullcalcitriolcognitionvitamin D deficiencycognition functionchild |
| spellingShingle | Ana Beatriz Januário da Silva Ana Beatriz Januário da Silva Waleska Maria Almeida Barros Waleska Maria Almeida Barros Mayara Luclécia da Silva Mayara Luclécia da Silva José Maurício Lucas Silva José Maurício Lucas Silva Ana Patrícia da Silva Souza Ana Patrícia da Silva Souza Karollainy Gomes da Silva Karollainy Gomes da Silva Matheus Santos de Sousa Fernandes Antonietta Cláudia Barbosa da Fonseca Carneiro Ana Elisa Toscano Cláudia Jacques Lagranha Cláudia Jacques Lagranha Impact of vitamin D on cognitive functions in healthy individuals: A systematic review in randomized controlled clinical trials Frontiers in Psychology calcitriol cognition vitamin D deficiency cognition function child |
| title | Impact of vitamin D on cognitive functions in healthy individuals: A systematic review in randomized controlled clinical trials |
| title_full | Impact of vitamin D on cognitive functions in healthy individuals: A systematic review in randomized controlled clinical trials |
| title_fullStr | Impact of vitamin D on cognitive functions in healthy individuals: A systematic review in randomized controlled clinical trials |
| title_full_unstemmed | Impact of vitamin D on cognitive functions in healthy individuals: A systematic review in randomized controlled clinical trials |
| title_short | Impact of vitamin D on cognitive functions in healthy individuals: A systematic review in randomized controlled clinical trials |
| title_sort | impact of vitamin d on cognitive functions in healthy individuals a systematic review in randomized controlled clinical trials |
| topic | calcitriol cognition vitamin D deficiency cognition function child |
| url | https://www.frontiersin.org/articles/10.3389/fpsyg.2022.987203/full |
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