Significance of pretransplant and de novo anti-HLA antibody detection after simultaneous pancreas-kidney transplantation
Introduction. Nowadays, there are few studies concerning assessment of the clinical significance of determining the level of pretransplant and de novo anti-HLA antibodies in patients after simultaneous pancreas-kidney transplantation.Aim. The study of the incidence, timing of formation and specifici...
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| Format: | Article |
| Language: | English |
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N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department
2022-09-01
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| Series: | Трансплантология (Москва) |
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| Online Access: | https://www.jtransplantologiya.ru/jour/article/view/682 |
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| author | I. V. Dmitriev N. V. Borovkova S. P. Shchelykalina N. V. Doronina N. S. Zhuravel A. V. Pinchuk |
| author_facet | I. V. Dmitriev N. V. Borovkova S. P. Shchelykalina N. V. Doronina N. S. Zhuravel A. V. Pinchuk |
| author_sort | I. V. Dmitriev |
| collection | DOAJ |
| description | Introduction. Nowadays, there are few studies concerning assessment of the clinical significance of determining the level of pretransplant and de novo anti-HLA antibodies in patients after simultaneous pancreas-kidney transplantation.Aim. The study of the incidence, timing of formation and specificity of pretransplant and de novo anti-HLA antibodies in patients after simultaneous pancreas-kidney transplantation.Material and methods. We conducted a prospective and retrospective research to study the incidence, timing of formation and specificity of pretransplant and de novo anti-HLA antibodies in 55 patients after simultaneous pancreas-kidney transplantation performed at the N.V. Sklifosovsky Research Institute for Emergency Medicine from 2008 to 2022.Results. There were 4 patients with preformed anti-HLA antibodies (7%). The formation of de novo anti-HLA antibodies after simultaneous pancreas-kidney transplantation was observed in 17 patients (31%). There were 5 patients with antiHLA class I, 3 patients with anti-HLA class II, 3 patients with anti-HLA class I and II, 5 patients with anti-MICA and 1 patient with both classes of anti-HLA and anti-MICA. The formation of de novo anti-HLA antibodies significantly increased the incidence of acute rejection (47% compared with 13%, p=0.014).Conclusion. The frequency of pretransplant and de novo anti-HLA antibody detection in the recipients at our Center is comparable to published data from other transplant centers. We obtained evidence that the formation of de novo antiHLA antibodies increases the incidence of acute rejection after simultaneous pancreas-kidney transplantation. |
| first_indexed | 2024-03-12T18:42:02Z |
| format | Article |
| id | doaj.art-acc8df8a23d945fdb79f1635af672b4d |
| institution | Directory Open Access Journal |
| issn | 2074-0506 2542-0909 |
| language | English |
| last_indexed | 2024-03-12T18:42:02Z |
| publishDate | 2022-09-01 |
| publisher | N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department |
| record_format | Article |
| series | Трансплантология (Москва) |
| spelling | doaj.art-acc8df8a23d945fdb79f1635af672b4d2023-08-02T07:48:51ZengN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare DepartmentТрансплантология (Москва)2074-05062542-09092022-09-0114325426410.23873/2074-0506-2022-14-3-254-264524Significance of pretransplant and de novo anti-HLA antibody detection after simultaneous pancreas-kidney transplantationI. V. Dmitriev0N. V. Borovkova1S. P. Shchelykalina2N. V. Doronina3N. S. Zhuravel4A. V. Pinchuk5ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»ФГАОУ ВО РНИМУ им. Н.И. Пирогова МЗ РФГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; Кафедра трансплантологии и искусственных органов ФГБОУ ВО МГМСУ им. А.И. Евдокимова МЗ РФ; ГБУ «НИИ организации здравоохранения и медицинского менеджмента ДЗМ»Introduction. Nowadays, there are few studies concerning assessment of the clinical significance of determining the level of pretransplant and de novo anti-HLA antibodies in patients after simultaneous pancreas-kidney transplantation.Aim. The study of the incidence, timing of formation and specificity of pretransplant and de novo anti-HLA antibodies in patients after simultaneous pancreas-kidney transplantation.Material and methods. We conducted a prospective and retrospective research to study the incidence, timing of formation and specificity of pretransplant and de novo anti-HLA antibodies in 55 patients after simultaneous pancreas-kidney transplantation performed at the N.V. Sklifosovsky Research Institute for Emergency Medicine from 2008 to 2022.Results. There were 4 patients with preformed anti-HLA antibodies (7%). The formation of de novo anti-HLA antibodies after simultaneous pancreas-kidney transplantation was observed in 17 patients (31%). There were 5 patients with antiHLA class I, 3 patients with anti-HLA class II, 3 patients with anti-HLA class I and II, 5 patients with anti-MICA and 1 patient with both classes of anti-HLA and anti-MICA. The formation of de novo anti-HLA antibodies significantly increased the incidence of acute rejection (47% compared with 13%, p=0.014).Conclusion. The frequency of pretransplant and de novo anti-HLA antibody detection in the recipients at our Center is comparable to published data from other transplant centers. We obtained evidence that the formation of de novo antiHLA antibodies increases the incidence of acute rejection after simultaneous pancreas-kidney transplantation.https://www.jtransplantologiya.ru/jour/article/view/682сочетанная трансплантация почки и поджелудочной железытрансплантационная иммунологияпредсуществующие анти-hla-антителавновь образованные антитела против hlade novo анти-hla-антителаострое отторжение |
| spellingShingle | I. V. Dmitriev N. V. Borovkova S. P. Shchelykalina N. V. Doronina N. S. Zhuravel A. V. Pinchuk Significance of pretransplant and de novo anti-HLA antibody detection after simultaneous pancreas-kidney transplantation Трансплантология (Москва) сочетанная трансплантация почки и поджелудочной железы трансплантационная иммунология предсуществующие анти-hla-антитела вновь образованные антитела против hla de novo анти-hla-антитела острое отторжение |
| title | Significance of pretransplant and de novo anti-HLA antibody detection after simultaneous pancreas-kidney transplantation |
| title_full | Significance of pretransplant and de novo anti-HLA antibody detection after simultaneous pancreas-kidney transplantation |
| title_fullStr | Significance of pretransplant and de novo anti-HLA antibody detection after simultaneous pancreas-kidney transplantation |
| title_full_unstemmed | Significance of pretransplant and de novo anti-HLA antibody detection after simultaneous pancreas-kidney transplantation |
| title_short | Significance of pretransplant and de novo anti-HLA antibody detection after simultaneous pancreas-kidney transplantation |
| title_sort | significance of pretransplant and de novo anti hla antibody detection after simultaneous pancreas kidney transplantation |
| topic | сочетанная трансплантация почки и поджелудочной железы трансплантационная иммунология предсуществующие анти-hla-антитела вновь образованные антитела против hla de novo анти-hla-антитела острое отторжение |
| url | https://www.jtransplantologiya.ru/jour/article/view/682 |
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