Significance of pretransplant and de novo anti-HLA antibody detection after simultaneous pancreas-kidney transplantation
Introduction. Nowadays, there are few studies concerning assessment of the clinical significance of determining the level of pretransplant and de novo anti-HLA antibodies in patients after simultaneous pancreas-kidney transplantation.Aim. The study of the incidence, timing of formation and specifici...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department
2022-09-01
|
| Series: | Трансплантология (Москва) |
| Subjects: | |
| Online Access: | https://www.jtransplantologiya.ru/jour/article/view/682 |
| _version_ | 1826564564575059968 |
|---|---|
| author | I. V. Dmitriev N. V. Borovkova S. P. Shchelykalina N. V. Doronina N. S. Zhuravel A. V. Pinchuk |
| author_facet | I. V. Dmitriev N. V. Borovkova S. P. Shchelykalina N. V. Doronina N. S. Zhuravel A. V. Pinchuk |
| author_sort | I. V. Dmitriev |
| collection | DOAJ |
| description | Introduction. Nowadays, there are few studies concerning assessment of the clinical significance of determining the level of pretransplant and de novo anti-HLA antibodies in patients after simultaneous pancreas-kidney transplantation.Aim. The study of the incidence, timing of formation and specificity of pretransplant and de novo anti-HLA antibodies in patients after simultaneous pancreas-kidney transplantation.Material and methods. We conducted a prospective and retrospective research to study the incidence, timing of formation and specificity of pretransplant and de novo anti-HLA antibodies in 55 patients after simultaneous pancreas-kidney transplantation performed at the N.V. Sklifosovsky Research Institute for Emergency Medicine from 2008 to 2022.Results. There were 4 patients with preformed anti-HLA antibodies (7%). The formation of de novo anti-HLA antibodies after simultaneous pancreas-kidney transplantation was observed in 17 patients (31%). There were 5 patients with antiHLA class I, 3 patients with anti-HLA class II, 3 patients with anti-HLA class I and II, 5 patients with anti-MICA and 1 patient with both classes of anti-HLA and anti-MICA. The formation of de novo anti-HLA antibodies significantly increased the incidence of acute rejection (47% compared with 13%, p=0.014).Conclusion. The frequency of pretransplant and de novo anti-HLA antibody detection in the recipients at our Center is comparable to published data from other transplant centers. We obtained evidence that the formation of de novo antiHLA antibodies increases the incidence of acute rejection after simultaneous pancreas-kidney transplantation. |
| first_indexed | 2024-03-12T18:42:02Z |
| format | Article |
| id | doaj.art-acc8df8a23d945fdb79f1635af672b4d |
| institution | Directory Open Access Journal |
| issn | 2074-0506 2542-0909 |
| language | English |
| last_indexed | 2025-03-14T10:21:52Z |
| publishDate | 2022-09-01 |
| publisher | N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department |
| record_format | Article |
| series | Трансплантология (Москва) |
| spelling | doaj.art-acc8df8a23d945fdb79f1635af672b4d2025-03-02T11:07:35ZengN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare DepartmentТрансплантология (Москва)2074-05062542-09092022-09-0114325426410.23873/2074-0506-2022-14-3-254-264524Significance of pretransplant and de novo anti-HLA antibody detection after simultaneous pancreas-kidney transplantationI. V. Dmitriev0N. V. Borovkova1S. P. Shchelykalina2N. V. Doronina3N. S. Zhuravel4A. V. Pinchuk5N.V. Sklifosovsky Research Institute for Emergency Medicine N.V. Sklifosovsky Research Institute for Emergency Medicine N.I. Pirogov Russian National Research Medical UniversityN.V. Sklifosovsky Research Institute for Emergency Medicine N.V. Sklifosovsky Research Institute for Emergency Medicine N.V. Sklifosovsky Research Institute for Emergency Medicine; A.I. Yevdokimov Moscow State University of Medicine and Dentistry; Research Institute for Healthcare Organization and Medical Management Introduction. Nowadays, there are few studies concerning assessment of the clinical significance of determining the level of pretransplant and de novo anti-HLA antibodies in patients after simultaneous pancreas-kidney transplantation.Aim. The study of the incidence, timing of formation and specificity of pretransplant and de novo anti-HLA antibodies in patients after simultaneous pancreas-kidney transplantation.Material and methods. We conducted a prospective and retrospective research to study the incidence, timing of formation and specificity of pretransplant and de novo anti-HLA antibodies in 55 patients after simultaneous pancreas-kidney transplantation performed at the N.V. Sklifosovsky Research Institute for Emergency Medicine from 2008 to 2022.Results. There were 4 patients with preformed anti-HLA antibodies (7%). The formation of de novo anti-HLA antibodies after simultaneous pancreas-kidney transplantation was observed in 17 patients (31%). There were 5 patients with antiHLA class I, 3 patients with anti-HLA class II, 3 patients with anti-HLA class I and II, 5 patients with anti-MICA and 1 patient with both classes of anti-HLA and anti-MICA. The formation of de novo anti-HLA antibodies significantly increased the incidence of acute rejection (47% compared with 13%, p=0.014).Conclusion. The frequency of pretransplant and de novo anti-HLA antibody detection in the recipients at our Center is comparable to published data from other transplant centers. We obtained evidence that the formation of de novo antiHLA antibodies increases the incidence of acute rejection after simultaneous pancreas-kidney transplantation.https://www.jtransplantologiya.ru/jour/article/view/682simultaneous pancreas-kidney transplantationtransplant immunologyde novo anti-hla antibodiespretransplant anti-hla antibodiesacute rejection |
| spellingShingle | I. V. Dmitriev N. V. Borovkova S. P. Shchelykalina N. V. Doronina N. S. Zhuravel A. V. Pinchuk Significance of pretransplant and de novo anti-HLA antibody detection after simultaneous pancreas-kidney transplantation Трансплантология (Москва) simultaneous pancreas-kidney transplantation transplant immunology de novo anti-hla antibodies pretransplant anti-hla antibodies acute rejection |
| title | Significance of pretransplant and de novo anti-HLA antibody detection after simultaneous pancreas-kidney transplantation |
| title_full | Significance of pretransplant and de novo anti-HLA antibody detection after simultaneous pancreas-kidney transplantation |
| title_fullStr | Significance of pretransplant and de novo anti-HLA antibody detection after simultaneous pancreas-kidney transplantation |
| title_full_unstemmed | Significance of pretransplant and de novo anti-HLA antibody detection after simultaneous pancreas-kidney transplantation |
| title_short | Significance of pretransplant and de novo anti-HLA antibody detection after simultaneous pancreas-kidney transplantation |
| title_sort | significance of pretransplant and de novo anti hla antibody detection after simultaneous pancreas kidney transplantation |
| topic | simultaneous pancreas-kidney transplantation transplant immunology de novo anti-hla antibodies pretransplant anti-hla antibodies acute rejection |
| url | https://www.jtransplantologiya.ru/jour/article/view/682 |
| work_keys_str_mv | AT ivdmitriev significanceofpretransplantanddenovoantihlaantibodydetectionaftersimultaneouspancreaskidneytransplantation AT nvborovkova significanceofpretransplantanddenovoantihlaantibodydetectionaftersimultaneouspancreaskidneytransplantation AT spshchelykalina significanceofpretransplantanddenovoantihlaantibodydetectionaftersimultaneouspancreaskidneytransplantation AT nvdoronina significanceofpretransplantanddenovoantihlaantibodydetectionaftersimultaneouspancreaskidneytransplantation AT nszhuravel significanceofpretransplantanddenovoantihlaantibodydetectionaftersimultaneouspancreaskidneytransplantation AT avpinchuk significanceofpretransplantanddenovoantihlaantibodydetectionaftersimultaneouspancreaskidneytransplantation |