The Queen and I: neural correlates of altered self-related cognitions in major depressive episode.
BACKGROUND: Pervasive negative thoughts about the self are central to the experience of depression. Brain imaging studies in the general population have localised self-related cognitive processing to areas of the medial pre-frontal cortex. AIMS: To use fMRI to compare the neural correlates of self-r...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3813625?pdf=render |
| _version_ | 1819132723350994944 |
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| author | May Sarsam Laura M Parkes Neil Roberts Graeme S Reid Peter Kinderman |
| author_facet | May Sarsam Laura M Parkes Neil Roberts Graeme S Reid Peter Kinderman |
| author_sort | May Sarsam |
| collection | DOAJ |
| description | BACKGROUND: Pervasive negative thoughts about the self are central to the experience of depression. Brain imaging studies in the general population have localised self-related cognitive processing to areas of the medial pre-frontal cortex. AIMS: To use fMRI to compare the neural correlates of self-referential processing in depressed and non-depressed participants. METHOD: Cross-sectional comparison of regional activation using Blood Oxygen Level Dependent (BOLD) fMRI in 13 non-medicated participants with major depressive episode and 14 comparison participants, whilst carrying out a self-referential cognitive task. RESULTS: Both groups showed significant activation of the dorsomedial pre-frontal cortex and posterior cingulate cortex in the 'self-referent' condition. The depressed group showed significantly greater activation in the medial superior frontal cortex during the self-referent task. No difference was observed between groups in the 'other-referent' condition. CONCLUSIONS: Major depressive episode is associated with specific neurofunctional changes related to self-referential processing. |
| first_indexed | 2024-12-22T09:35:56Z |
| format | Article |
| id | doaj.art-acc9538f66ad4a1eacb67bc428611616 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T09:35:56Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-acc9538f66ad4a1eacb67bc4286116162022-12-21T18:30:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01810e7884410.1371/journal.pone.0078844The Queen and I: neural correlates of altered self-related cognitions in major depressive episode.May SarsamLaura M ParkesNeil RobertsGraeme S ReidPeter KindermanBACKGROUND: Pervasive negative thoughts about the self are central to the experience of depression. Brain imaging studies in the general population have localised self-related cognitive processing to areas of the medial pre-frontal cortex. AIMS: To use fMRI to compare the neural correlates of self-referential processing in depressed and non-depressed participants. METHOD: Cross-sectional comparison of regional activation using Blood Oxygen Level Dependent (BOLD) fMRI in 13 non-medicated participants with major depressive episode and 14 comparison participants, whilst carrying out a self-referential cognitive task. RESULTS: Both groups showed significant activation of the dorsomedial pre-frontal cortex and posterior cingulate cortex in the 'self-referent' condition. The depressed group showed significantly greater activation in the medial superior frontal cortex during the self-referent task. No difference was observed between groups in the 'other-referent' condition. CONCLUSIONS: Major depressive episode is associated with specific neurofunctional changes related to self-referential processing.http://europepmc.org/articles/PMC3813625?pdf=render |
| spellingShingle | May Sarsam Laura M Parkes Neil Roberts Graeme S Reid Peter Kinderman The Queen and I: neural correlates of altered self-related cognitions in major depressive episode. PLoS ONE |
| title | The Queen and I: neural correlates of altered self-related cognitions in major depressive episode. |
| title_full | The Queen and I: neural correlates of altered self-related cognitions in major depressive episode. |
| title_fullStr | The Queen and I: neural correlates of altered self-related cognitions in major depressive episode. |
| title_full_unstemmed | The Queen and I: neural correlates of altered self-related cognitions in major depressive episode. |
| title_short | The Queen and I: neural correlates of altered self-related cognitions in major depressive episode. |
| title_sort | queen and i neural correlates of altered self related cognitions in major depressive episode |
| url | http://europepmc.org/articles/PMC3813625?pdf=render |
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