Epidemiology and risk factors of infective endocarditis in a tertiary hospital in China from 2007 to 2016
Abstract Background To explore the trends in epidemiology and the risk factors related to the prognosis of infective endocarditis in a tertiary hospital over the past ten years. Methods A retrospective cohort study was performed. A total of 407 consecutive patients who were admitted with infective e...
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | http://link.springer.com/article/10.1186/s12879-020-05153-w |
| _version_ | 1811315298510307328 |
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| author | Zhenzhu Wu Yi Chen Tingting Xiao Tianshui Niu Qingyi Shi Yonghong Xiao |
| author_facet | Zhenzhu Wu Yi Chen Tingting Xiao Tianshui Niu Qingyi Shi Yonghong Xiao |
| author_sort | Zhenzhu Wu |
| collection | DOAJ |
| description | Abstract Background To explore the trends in epidemiology and the risk factors related to the prognosis of infective endocarditis in a tertiary hospital over the past ten years. Methods A retrospective cohort study was performed. A total of 407 consecutive patients who were admitted with infective endocarditis were included. The clinical characteristics and the risk factors related to the prognosis of infective endocarditis during this period were analyzed. Results A total of 407 patients with infective endocarditis were included, the average age was 48 ± 16 years old with an increasing trend and in-hospital mortality rate was 10.6% and one-year mortality rate was 11.3%. Among patients with underlying heart disease, congenital heart disease was the most common (25.8%), followed by rheumatic heart disease (17.0%) which showed a decreased trend during this period (P < 0.001). There were 222(54.5%) patients with positive blood cultures results and Streptococci (24.6%) was the main pathogens with an increasing trend. There were 403 patients (99%) with surgical indications, but only 235 patients (57.7%) received surgical treatment. Hemodialysis (P = 0.041, OR = 4.697, 95% CI 1.068–20.665), pulmonary hypertension (P = 0.001, OR = 5.308, 95% CI 2.034–13.852), Pitt score ≥ 4 (P < 0.001, OR = 28.594, 95% CI 5.561–148.173) and vegetation length>30 mm (P = 0.011, OR = 13.754, 95% CI 1.832–103.250) were independent risk factors for in-hospital mortality. Conclusions There were no significant changes in the overall incidence of infective endocarditis, but the clinical features of infective endocarditis had slightly changed during the past ten years. Streptococci infective endocarditis was still the predominant. Patients with hemodialysis, pulmonary hypertension, Pitt score ≥ 4 and vegetation length>30 mm had an worse in-hospital outcome. |
| first_indexed | 2024-04-13T11:27:46Z |
| format | Article |
| id | doaj.art-acc9a3046c7047dda1bf28411f2f6217 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-13T11:27:46Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-acc9a3046c7047dda1bf28411f2f62172022-12-22T02:48:38ZengBMCBMC Infectious Diseases1471-23342020-06-0120111010.1186/s12879-020-05153-wEpidemiology and risk factors of infective endocarditis in a tertiary hospital in China from 2007 to 2016Zhenzhu Wu0Yi Chen1Tingting Xiao2Tianshui Niu3Qingyi Shi4Yonghong Xiao5State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang UniversityState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang UniversityState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang UniversityState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang UniversityState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang UniversityState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang UniversityAbstract Background To explore the trends in epidemiology and the risk factors related to the prognosis of infective endocarditis in a tertiary hospital over the past ten years. Methods A retrospective cohort study was performed. A total of 407 consecutive patients who were admitted with infective endocarditis were included. The clinical characteristics and the risk factors related to the prognosis of infective endocarditis during this period were analyzed. Results A total of 407 patients with infective endocarditis were included, the average age was 48 ± 16 years old with an increasing trend and in-hospital mortality rate was 10.6% and one-year mortality rate was 11.3%. Among patients with underlying heart disease, congenital heart disease was the most common (25.8%), followed by rheumatic heart disease (17.0%) which showed a decreased trend during this period (P < 0.001). There were 222(54.5%) patients with positive blood cultures results and Streptococci (24.6%) was the main pathogens with an increasing trend. There were 403 patients (99%) with surgical indications, but only 235 patients (57.7%) received surgical treatment. Hemodialysis (P = 0.041, OR = 4.697, 95% CI 1.068–20.665), pulmonary hypertension (P = 0.001, OR = 5.308, 95% CI 2.034–13.852), Pitt score ≥ 4 (P < 0.001, OR = 28.594, 95% CI 5.561–148.173) and vegetation length>30 mm (P = 0.011, OR = 13.754, 95% CI 1.832–103.250) were independent risk factors for in-hospital mortality. Conclusions There were no significant changes in the overall incidence of infective endocarditis, but the clinical features of infective endocarditis had slightly changed during the past ten years. Streptococci infective endocarditis was still the predominant. Patients with hemodialysis, pulmonary hypertension, Pitt score ≥ 4 and vegetation length>30 mm had an worse in-hospital outcome.http://link.springer.com/article/10.1186/s12879-020-05153-wInfective endocarditisEpidemiologyRisk factorsMortality |
| spellingShingle | Zhenzhu Wu Yi Chen Tingting Xiao Tianshui Niu Qingyi Shi Yonghong Xiao Epidemiology and risk factors of infective endocarditis in a tertiary hospital in China from 2007 to 2016 BMC Infectious Diseases Infective endocarditis Epidemiology Risk factors Mortality |
| title | Epidemiology and risk factors of infective endocarditis in a tertiary hospital in China from 2007 to 2016 |
| title_full | Epidemiology and risk factors of infective endocarditis in a tertiary hospital in China from 2007 to 2016 |
| title_fullStr | Epidemiology and risk factors of infective endocarditis in a tertiary hospital in China from 2007 to 2016 |
| title_full_unstemmed | Epidemiology and risk factors of infective endocarditis in a tertiary hospital in China from 2007 to 2016 |
| title_short | Epidemiology and risk factors of infective endocarditis in a tertiary hospital in China from 2007 to 2016 |
| title_sort | epidemiology and risk factors of infective endocarditis in a tertiary hospital in china from 2007 to 2016 |
| topic | Infective endocarditis Epidemiology Risk factors Mortality |
| url | http://link.springer.com/article/10.1186/s12879-020-05153-w |
| work_keys_str_mv | AT zhenzhuwu epidemiologyandriskfactorsofinfectiveendocarditisinatertiaryhospitalinchinafrom2007to2016 AT yichen epidemiologyandriskfactorsofinfectiveendocarditisinatertiaryhospitalinchinafrom2007to2016 AT tingtingxiao epidemiologyandriskfactorsofinfectiveendocarditisinatertiaryhospitalinchinafrom2007to2016 AT tianshuiniu epidemiologyandriskfactorsofinfectiveendocarditisinatertiaryhospitalinchinafrom2007to2016 AT qingyishi epidemiologyandriskfactorsofinfectiveendocarditisinatertiaryhospitalinchinafrom2007to2016 AT yonghongxiao epidemiologyandriskfactorsofinfectiveendocarditisinatertiaryhospitalinchinafrom2007to2016 |