Lessons Learned from Donor Cell-Derived Myeloid Neoplasms: Report of Three Cases and Review of the Literature
Donor-cell derived myeloid neoplasm (DDMN), a rare complication after allogeneic hematopoietic cell transplantation (HCT), is of interest for its potential to reveal donor-derived and host-derived factors that contribute to the pathogenesis of leukemia. The accurate diagnosis of donor-derived leukem...
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| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/4/559 |
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| author | Komal Galani Deshmukh Katalin Kelemen |
| author_facet | Komal Galani Deshmukh Katalin Kelemen |
| author_sort | Komal Galani Deshmukh |
| collection | DOAJ |
| description | Donor-cell derived myeloid neoplasm (DDMN), a rare complication after allogeneic hematopoietic cell transplantation (HCT), is of interest for its potential to reveal donor-derived and host-derived factors that contribute to the pathogenesis of leukemia. The accurate diagnosis of donor-derived leukemias has been facilitated by the more frequent use of molecular techniques. In this study, we describe three additional cases of DDMN; the first reported case of donor-derived chronic myelomonocytic leukemia (CMML), one acute myeloid leukemia (AML) with t(8;21)(q22;22); <i>RUNX1-RUNX1T1</i> and one donor-derived MDS with deletion 5q. A review of the cytogenetic profiles of previously reported DDMN indicates a significant contribution of therapy-related myeloid neoplasms. Cases with direct evidence of donor- or recipient-dependent factors are rare; a role of direct transfer of leukemic cells, genomic instability of the donor, abnormal gene methylation in donor cells, proleukemic potential of abnormal stromal niche, and the role of immunological surveillance after transplantation has been observed. The role of additional potential pathogenetic factors that are without clinically observed evidence are also reviewed. |
| first_indexed | 2024-03-09T04:30:04Z |
| format | Article |
| id | doaj.art-acca5f0b7c534782a8fb7bb70649c167 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T04:30:04Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-acca5f0b7c534782a8fb7bb70649c1672023-12-03T13:37:16ZengMDPI AGLife2075-17292022-04-0112455910.3390/life12040559Lessons Learned from Donor Cell-Derived Myeloid Neoplasms: Report of Three Cases and Review of the LiteratureKomal Galani Deshmukh0Katalin Kelemen1Star Superspeciality Hospital, Nagpur 440012, IndiaDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Phoenix, AZ 85054, USADonor-cell derived myeloid neoplasm (DDMN), a rare complication after allogeneic hematopoietic cell transplantation (HCT), is of interest for its potential to reveal donor-derived and host-derived factors that contribute to the pathogenesis of leukemia. The accurate diagnosis of donor-derived leukemias has been facilitated by the more frequent use of molecular techniques. In this study, we describe three additional cases of DDMN; the first reported case of donor-derived chronic myelomonocytic leukemia (CMML), one acute myeloid leukemia (AML) with t(8;21)(q22;22); <i>RUNX1-RUNX1T1</i> and one donor-derived MDS with deletion 5q. A review of the cytogenetic profiles of previously reported DDMN indicates a significant contribution of therapy-related myeloid neoplasms. Cases with direct evidence of donor- or recipient-dependent factors are rare; a role of direct transfer of leukemic cells, genomic instability of the donor, abnormal gene methylation in donor cells, proleukemic potential of abnormal stromal niche, and the role of immunological surveillance after transplantation has been observed. The role of additional potential pathogenetic factors that are without clinically observed evidence are also reviewed.https://www.mdpi.com/2075-1729/12/4/559donor cell-derived leukemiamyeloid neoplasmhematopoietic stem cell transplantationtherapy-related myeloid neoplasmcytogenetic findingsbone marrow niche |
| spellingShingle | Komal Galani Deshmukh Katalin Kelemen Lessons Learned from Donor Cell-Derived Myeloid Neoplasms: Report of Three Cases and Review of the Literature Life donor cell-derived leukemia myeloid neoplasm hematopoietic stem cell transplantation therapy-related myeloid neoplasm cytogenetic findings bone marrow niche |
| title | Lessons Learned from Donor Cell-Derived Myeloid Neoplasms: Report of Three Cases and Review of the Literature |
| title_full | Lessons Learned from Donor Cell-Derived Myeloid Neoplasms: Report of Three Cases and Review of the Literature |
| title_fullStr | Lessons Learned from Donor Cell-Derived Myeloid Neoplasms: Report of Three Cases and Review of the Literature |
| title_full_unstemmed | Lessons Learned from Donor Cell-Derived Myeloid Neoplasms: Report of Three Cases and Review of the Literature |
| title_short | Lessons Learned from Donor Cell-Derived Myeloid Neoplasms: Report of Three Cases and Review of the Literature |
| title_sort | lessons learned from donor cell derived myeloid neoplasms report of three cases and review of the literature |
| topic | donor cell-derived leukemia myeloid neoplasm hematopoietic stem cell transplantation therapy-related myeloid neoplasm cytogenetic findings bone marrow niche |
| url | https://www.mdpi.com/2075-1729/12/4/559 |
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