Collagen XV, a multifaceted multiplexin present across tissues and species
Type XV collagen is a non-fibrillar collagen that is associated with basement membranes and belongs to the multiplexin subset of the collagen superfamily. Collagen XV was initially studied because of its sequence homology with collagen XVIII/endostatin whose anti-angiogenic and anti-tumorigenic prop...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-05-01
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| Series: | Matrix Biology Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590028520300041 |
| _version_ | 1811222827917901824 |
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| author | Sandrine Bretaud Emilie Guillon Sanna-Maria Karppinen Taina Pihlajaniemi Florence Ruggiero |
| author_facet | Sandrine Bretaud Emilie Guillon Sanna-Maria Karppinen Taina Pihlajaniemi Florence Ruggiero |
| author_sort | Sandrine Bretaud |
| collection | DOAJ |
| description | Type XV collagen is a non-fibrillar collagen that is associated with basement membranes and belongs to the multiplexin subset of the collagen superfamily. Collagen XV was initially studied because of its sequence homology with collagen XVIII/endostatin whose anti-angiogenic and anti-tumorigenic properties were subjects of wide interest in the past years. But during the last fifteen years, collagen XV has gained growing attention with increasing number of studies that have attributed new functions to this widely distributed collagen/proteoglycan hybrid molecule. Despite the cumulative evidence of its functional pleiotropy and its evolutionary conserved function, no review compiling the current state of the art about collagen XV is currently available. Here, we thus provide the first comprehensive view of the knowledge gathered so far on the molecular structure, tissue distribution and functions of collagen XV in development, tissue homeostasis and disease with an evolutionary perspective. We hope that our review will open new roads for promising research on collagen XV in the coming years. |
| first_indexed | 2024-04-12T08:22:21Z |
| format | Article |
| id | doaj.art-accb4768a4bc4fba8df5b094408259e1 |
| institution | Directory Open Access Journal |
| issn | 2590-0285 |
| language | English |
| last_indexed | 2024-04-12T08:22:21Z |
| publishDate | 2020-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Matrix Biology Plus |
| spelling | doaj.art-accb4768a4bc4fba8df5b094408259e12022-12-22T03:40:32ZengElsevierMatrix Biology Plus2590-02852020-05-016100023Collagen XV, a multifaceted multiplexin present across tissues and speciesSandrine Bretaud0Emilie Guillon1Sanna-Maria Karppinen2Taina Pihlajaniemi3Florence Ruggiero4Institut de Génomique Fonctionnelle de Lyon, ENS de Lyon, UMR CNRS 5242, University of Lyon, Lyon 69364, FranceInstitut de Génomique Fonctionnelle de Lyon, ENS de Lyon, UMR CNRS 5242, University of Lyon, Lyon 69364, FranceCenter for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Aapistie 7C, FI-90230 Oulu, FinlandCenter for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Aapistie 7C, FI-90230 Oulu, FinlandInstitut de Génomique Fonctionnelle de Lyon, ENS de Lyon, UMR CNRS 5242, University of Lyon, Lyon 69364, France; Corresponding author at: Institut de Génomique Fonctionnelle de Lyon - ENS de Lyon, 46 Allée d'Italie, F69364 Lyon cedex 07, France.Type XV collagen is a non-fibrillar collagen that is associated with basement membranes and belongs to the multiplexin subset of the collagen superfamily. Collagen XV was initially studied because of its sequence homology with collagen XVIII/endostatin whose anti-angiogenic and anti-tumorigenic properties were subjects of wide interest in the past years. But during the last fifteen years, collagen XV has gained growing attention with increasing number of studies that have attributed new functions to this widely distributed collagen/proteoglycan hybrid molecule. Despite the cumulative evidence of its functional pleiotropy and its evolutionary conserved function, no review compiling the current state of the art about collagen XV is currently available. Here, we thus provide the first comprehensive view of the knowledge gathered so far on the molecular structure, tissue distribution and functions of collagen XV in development, tissue homeostasis and disease with an evolutionary perspective. We hope that our review will open new roads for promising research on collagen XV in the coming years.http://www.sciencedirect.com/science/article/pii/S2590028520300041CollagensMultiplexinExtracellular matrixAnimal modelsDevelopmentCollagen-related disease |
| spellingShingle | Sandrine Bretaud Emilie Guillon Sanna-Maria Karppinen Taina Pihlajaniemi Florence Ruggiero Collagen XV, a multifaceted multiplexin present across tissues and species Matrix Biology Plus Collagens Multiplexin Extracellular matrix Animal models Development Collagen-related disease |
| title | Collagen XV, a multifaceted multiplexin present across tissues and species |
| title_full | Collagen XV, a multifaceted multiplexin present across tissues and species |
| title_fullStr | Collagen XV, a multifaceted multiplexin present across tissues and species |
| title_full_unstemmed | Collagen XV, a multifaceted multiplexin present across tissues and species |
| title_short | Collagen XV, a multifaceted multiplexin present across tissues and species |
| title_sort | collagen xv a multifaceted multiplexin present across tissues and species |
| topic | Collagens Multiplexin Extracellular matrix Animal models Development Collagen-related disease |
| url | http://www.sciencedirect.com/science/article/pii/S2590028520300041 |
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