Topical Therapeutic Options in Corneal Neuropathic Pain
Purpose of Review: Corneal neuropathic pain can be difficult to treat, particularly due to its lack of response to standard dry eye therapies. We describe a variety of topical therapeutic options that are available to treat corneal neuropathic pain with a significant or primary peripheral component....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.769909/full |
| _version_ | 1798025026218229760 |
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| author | Jeremy Nortey Jeremy Nortey David Smith Gerami D. Seitzman Gerami D. Seitzman John A. Gonzales John A. Gonzales |
| author_facet | Jeremy Nortey Jeremy Nortey David Smith Gerami D. Seitzman Gerami D. Seitzman John A. Gonzales John A. Gonzales |
| author_sort | Jeremy Nortey |
| collection | DOAJ |
| description | Purpose of Review: Corneal neuropathic pain can be difficult to treat, particularly due to its lack of response to standard dry eye therapies. We describe a variety of topical therapeutic options that are available to treat corneal neuropathic pain with a significant or primary peripheral component. We also describe possible mechanisms of action for such topical therapies.Recent Findings: Topical corticosteroids and blood-derived tear preparations can be helpful. Newer therapies, including topical lacosamide and low-dose naltrexone are emerging therapeutic options that may also be considered.Summary: Corneal neuropathic pain with a significant peripheral component may be managed with a variety of topical therapeutic options. |
| first_indexed | 2024-04-11T18:12:16Z |
| format | Article |
| id | doaj.art-accb48c6ae754125a0776ba5fd038b7c |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T18:12:16Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-accb48c6ae754125a0776ba5fd038b7c2022-12-22T04:10:04ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-01-011210.3389/fphar.2021.769909769909Topical Therapeutic Options in Corneal Neuropathic PainJeremy Nortey0Jeremy Nortey1David Smith2Gerami D. Seitzman3Gerami D. Seitzman4John A. Gonzales5John A. Gonzales6School of Medicine, University of North Carolina, Chapel Hill, NC, United StatesaFrancis I. Proctor Foundation, University of California, San Francisco, San Francisco, CA, United StatesA&O Compounding Pharmacy, Vallejo, CA, United StatesFrancis I. Proctor Foundation, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Ophthalmology, University of California, San Francisco, San Francisco, CA, United StatesFrancis I. Proctor Foundation, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Ophthalmology, University of California, San Francisco, San Francisco, CA, United StatesPurpose of Review: Corneal neuropathic pain can be difficult to treat, particularly due to its lack of response to standard dry eye therapies. We describe a variety of topical therapeutic options that are available to treat corneal neuropathic pain with a significant or primary peripheral component. We also describe possible mechanisms of action for such topical therapies.Recent Findings: Topical corticosteroids and blood-derived tear preparations can be helpful. Newer therapies, including topical lacosamide and low-dose naltrexone are emerging therapeutic options that may also be considered.Summary: Corneal neuropathic pain with a significant peripheral component may be managed with a variety of topical therapeutic options.https://www.frontiersin.org/articles/10.3389/fphar.2021.769909/fullcorneal neuropathic painneuropathic ocular painlow-dose naltrexonelacosamidesub-basal corneal nerve plexusserum tears |
| spellingShingle | Jeremy Nortey Jeremy Nortey David Smith Gerami D. Seitzman Gerami D. Seitzman John A. Gonzales John A. Gonzales Topical Therapeutic Options in Corneal Neuropathic Pain Frontiers in Pharmacology corneal neuropathic pain neuropathic ocular pain low-dose naltrexone lacosamide sub-basal corneal nerve plexus serum tears |
| title | Topical Therapeutic Options in Corneal Neuropathic Pain |
| title_full | Topical Therapeutic Options in Corneal Neuropathic Pain |
| title_fullStr | Topical Therapeutic Options in Corneal Neuropathic Pain |
| title_full_unstemmed | Topical Therapeutic Options in Corneal Neuropathic Pain |
| title_short | Topical Therapeutic Options in Corneal Neuropathic Pain |
| title_sort | topical therapeutic options in corneal neuropathic pain |
| topic | corneal neuropathic pain neuropathic ocular pain low-dose naltrexone lacosamide sub-basal corneal nerve plexus serum tears |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.769909/full |
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