In Silico, In Vitro, and Pharmacokinetic Studies of UBMC-4, a Potential Novel Compound for Treating against <i>Trypanosoma cruzi</i>

In Silico, In Vitro, and Pharmacokinetic Studies of UBMC-4, a Potential Novel Compound for Treating against <i>Trypanosoma cruzi</i>

The lack of therapeutic alternatives for the treatment of Chagas disease, a neglected disease, drives the discovery of new drugs with trypanocidal activity. Consequently, we conducted in vitro studies using UBMC-4, a potential <i>Trypanosoma cruzi</i> AKT-like pleckstrin homology (PH) do...

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Bibliographic Details
Main Authors: Christian Bustamante, Andrés Felipe Díez-Mejía, Natalia Arbeláez, Maurilio José Soares, Sara M. Robledo, Rodrigo Ochoa, Rubén E. Varela-M., Marcel Marín-Villa
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Pathogens
Subjects:
Chagas disease
<i>Trypanosoma cruzi</i>
AKT-like serine/threonine kinase
drug discovery
molecular docking
UBMC-4 inhibitor
Online Access:https://www.mdpi.com/2076-0817/11/6/616

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