Emerging roles of TFE3 in metabolic regulation
Abstract TFE3 is a member of the MiT family of the bHLH-leucine zipper transcription factor. We previously focused on the role of TFE3 in autophagy and cancer. Recently, an increasing number of studies have revealed that TFE3 plays an important role in metabolic regulation. TFE3 participates in the...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-03-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-023-01395-0 |
| _version_ | 1797865556587577344 |
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| author | Xingyu Li Yongming Chen Siqiao Gong Huixia Chen Huafeng Liu Xiaoyu Li Junfeng Hao |
| author_facet | Xingyu Li Yongming Chen Siqiao Gong Huixia Chen Huafeng Liu Xiaoyu Li Junfeng Hao |
| author_sort | Xingyu Li |
| collection | DOAJ |
| description | Abstract TFE3 is a member of the MiT family of the bHLH-leucine zipper transcription factor. We previously focused on the role of TFE3 in autophagy and cancer. Recently, an increasing number of studies have revealed that TFE3 plays an important role in metabolic regulation. TFE3 participates in the metabolism of energy in the body by regulating pathways such as glucose and lipid metabolism, mitochondrial metabolism, and autophagy. This review summarizes and discusses the specific regulatory mechanisms of TFE3 in metabolism. We determined both the direct regulation of TFE3 on metabolically active cells, such as hepatocytes and skeletal muscle cells, and the indirect regulation of TFE3 through mitochondrial quality control and the autophagy–lysosome pathway. The role of TFE3 in tumor cell metabolism is also summarized in this review. Understanding the diverse roles of TFE3 in metabolic processes can provide new avenues for the treatment of some metabolism-related disorders. |
| first_indexed | 2024-04-09T23:11:04Z |
| format | Article |
| id | doaj.art-accdceaacd544d35a6fbb75ae800dca7 |
| institution | Directory Open Access Journal |
| issn | 2058-7716 |
| language | English |
| last_indexed | 2024-04-09T23:11:04Z |
| publishDate | 2023-03-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj.art-accdceaacd544d35a6fbb75ae800dca72023-03-22T10:25:41ZengNature Publishing GroupCell Death Discovery2058-77162023-03-01911910.1038/s41420-023-01395-0Emerging roles of TFE3 in metabolic regulationXingyu Li0Yongming Chen1Siqiao Gong2Huixia Chen3Huafeng Liu4Xiaoyu Li5Junfeng Hao6Institute of Nephrology, and Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases, Affiliated Hospital of Guangdong Medical UniversityInstitute of Nephrology, and Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases, Affiliated Hospital of Guangdong Medical UniversityInstitute of Nephrology, and Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases, Affiliated Hospital of Guangdong Medical UniversityInstitute of Nephrology, and Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases, Affiliated Hospital of Guangdong Medical UniversityInstitute of Nephrology, and Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases, Affiliated Hospital of Guangdong Medical UniversityInstitute of Nephrology, and Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases, Affiliated Hospital of Guangdong Medical UniversityInstitute of Nephrology, and Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases, Affiliated Hospital of Guangdong Medical UniversityAbstract TFE3 is a member of the MiT family of the bHLH-leucine zipper transcription factor. We previously focused on the role of TFE3 in autophagy and cancer. Recently, an increasing number of studies have revealed that TFE3 plays an important role in metabolic regulation. TFE3 participates in the metabolism of energy in the body by regulating pathways such as glucose and lipid metabolism, mitochondrial metabolism, and autophagy. This review summarizes and discusses the specific regulatory mechanisms of TFE3 in metabolism. We determined both the direct regulation of TFE3 on metabolically active cells, such as hepatocytes and skeletal muscle cells, and the indirect regulation of TFE3 through mitochondrial quality control and the autophagy–lysosome pathway. The role of TFE3 in tumor cell metabolism is also summarized in this review. Understanding the diverse roles of TFE3 in metabolic processes can provide new avenues for the treatment of some metabolism-related disorders.https://doi.org/10.1038/s41420-023-01395-0 |
| spellingShingle | Xingyu Li Yongming Chen Siqiao Gong Huixia Chen Huafeng Liu Xiaoyu Li Junfeng Hao Emerging roles of TFE3 in metabolic regulation Cell Death Discovery |
| title | Emerging roles of TFE3 in metabolic regulation |
| title_full | Emerging roles of TFE3 in metabolic regulation |
| title_fullStr | Emerging roles of TFE3 in metabolic regulation |
| title_full_unstemmed | Emerging roles of TFE3 in metabolic regulation |
| title_short | Emerging roles of TFE3 in metabolic regulation |
| title_sort | emerging roles of tfe3 in metabolic regulation |
| url | https://doi.org/10.1038/s41420-023-01395-0 |
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