Effects of Roflumilast, Selective PDE4 Inhibitor, on Airway Reactivity in Ovalbumin-Sensitized Guinea Pigs

Effects of Roflumilast, Selective PDE4 Inhibitor, on Airway Reactivity in Ovalbumin-Sensitized Guinea Pigs

Background: Roflumilast as a phosphodiesterase 4 inhibitor has shown to increase lung functions and decrease the number of exacerbations in chronic obstructive lung disease. In this study, its ability to decrease the airway hyperresponsiveness in a model of eosinophil inflammation was evaluated. Met...

Full description

Bibliographic Details
Main Authors: Tharmalingam Nirmathan, Medvedova I., Eichlerova A., Prso M., Mokra D., Mokry J.
Format: Article
Language:English
Published: Sciendo 2015-05-01
Series:Acta Medica Martiniana
Subjects:
roflumilast
ovalbumin
phosphodiesterase inhibitors
airway reactivity
eosinophil inflammation
bronchial asthma
Online Access:https://doi.org/10.1515/acm-2015-0002

Similar Items

Similar Items