Late-onset rash in patients with group A beta-hemolytic streptococcal pharyngitis treated with amoxicillin
We observed late-onset rashes in patients with group A beta-hemolytic streptococcal (GAS) pharyngitis. Of 1028 patients with GAS pharyngitis, which was principally treated with amoxicillin, we evaluated those who developed a late-onset rash and excluded those with scarlet fever alone. Twenty-one pat...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2015-12-01
|
| Series: | Pediatric Reports |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/pr/article/view/5951 |
| _version_ | 1818964232252686336 |
|---|---|
| author | Masahiko Kimura |
| author_facet | Masahiko Kimura |
| author_sort | Masahiko Kimura |
| collection | DOAJ |
| description | We observed late-onset rashes in patients with group A beta-hemolytic streptococcal (GAS) pharyngitis. Of 1028 patients with GAS pharyngitis, which was principally treated with amoxicillin, we evaluated those who developed a late-onset rash and excluded those with scarlet fever alone. Twenty-one patients developed a rash (2.0%, 95% confidence interval, 1.3- 3.1%), 7 to 20 days (median, 8 days) after GAS pharyngitis onset. The rashes were characterized by maculopapules, which increased in size with coalescence and some developing into plaques, with a symmetrical distribution with a propensity for the extremities, including the palms and soles. The clinical courses of the patients were good, and the rashes subsided within 14 days. A non-immediate reaction to β-lactams, which usually manifests as a maculopapular rash, is a possible cause in our patients, however, repeated courses of amoxicillin in 3 patients did not induce the rash. The underlying mechanism of the late-onset rash after GAS pharyngitis with amoxicillin treatment remains unclear. |
| first_indexed | 2024-12-20T12:57:50Z |
| format | Article |
| id | doaj.art-acd01ee4c164478593a36c2c637f4ac0 |
| institution | Directory Open Access Journal |
| issn | 2036-749X 2036-7503 |
| language | English |
| last_indexed | 2024-12-20T12:57:50Z |
| publishDate | 2015-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pediatric Reports |
| spelling | doaj.art-acd01ee4c164478593a36c2c637f4ac02022-12-21T19:40:01ZengMDPI AGPediatric Reports2036-749X2036-75032015-12-017410.4081/pr.2015.59513228Late-onset rash in patients with group A beta-hemolytic streptococcal pharyngitis treated with amoxicillinMasahiko Kimura0Kimura Children and Family Clinic, IzumoWe observed late-onset rashes in patients with group A beta-hemolytic streptococcal (GAS) pharyngitis. Of 1028 patients with GAS pharyngitis, which was principally treated with amoxicillin, we evaluated those who developed a late-onset rash and excluded those with scarlet fever alone. Twenty-one patients developed a rash (2.0%, 95% confidence interval, 1.3- 3.1%), 7 to 20 days (median, 8 days) after GAS pharyngitis onset. The rashes were characterized by maculopapules, which increased in size with coalescence and some developing into plaques, with a symmetrical distribution with a propensity for the extremities, including the palms and soles. The clinical courses of the patients were good, and the rashes subsided within 14 days. A non-immediate reaction to β-lactams, which usually manifests as a maculopapular rash, is a possible cause in our patients, however, repeated courses of amoxicillin in 3 patients did not induce the rash. The underlying mechanism of the late-onset rash after GAS pharyngitis with amoxicillin treatment remains unclear.http://www.pagepress.org/journals/index.php/pr/article/view/5951Group A beta-hemolytic streptococcal pharyngitislate-onset rashamoxicillinnon-immediate reactionsallergy |
| spellingShingle | Masahiko Kimura Late-onset rash in patients with group A beta-hemolytic streptococcal pharyngitis treated with amoxicillin Pediatric Reports Group A beta-hemolytic streptococcal pharyngitis late-onset rash amoxicillin non-immediate reactions allergy |
| title | Late-onset rash in patients with group A beta-hemolytic streptococcal pharyngitis treated with amoxicillin |
| title_full | Late-onset rash in patients with group A beta-hemolytic streptococcal pharyngitis treated with amoxicillin |
| title_fullStr | Late-onset rash in patients with group A beta-hemolytic streptococcal pharyngitis treated with amoxicillin |
| title_full_unstemmed | Late-onset rash in patients with group A beta-hemolytic streptococcal pharyngitis treated with amoxicillin |
| title_short | Late-onset rash in patients with group A beta-hemolytic streptococcal pharyngitis treated with amoxicillin |
| title_sort | late onset rash in patients with group a beta hemolytic streptococcal pharyngitis treated with amoxicillin |
| topic | Group A beta-hemolytic streptococcal pharyngitis late-onset rash amoxicillin non-immediate reactions allergy |
| url | http://www.pagepress.org/journals/index.php/pr/article/view/5951 |
| work_keys_str_mv | AT masahikokimura lateonsetrashinpatientswithgroupabetahemolyticstreptococcalpharyngitistreatedwithamoxicillin |