Comparison of the protective effect of cytosolic and mitochondrial Peroxiredoxin 5 against glutamate-induced neuronal cell death

Comparison of the protective effect of cytosolic and mitochondrial Peroxiredoxin 5 against glutamate-induced neuronal cell death

Objectives: Although glutamate is an essential factor in the neuronal system, excess glutamate can produce excitotoxicity. We previously reported that Peroxiredoxin 5 (Prx5) protects neuronal cells from glutamate toxicity via its antioxidant effects. However, it is unclear whether cytosolic or mitoc...

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Bibliographic Details
Main Authors: Mi Hye Kim, Da Yeon Kim, Hong Jun Lee, Young-Ho Park, Jae-Won Huh, Dong-Seok Lee
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Redox Report
Subjects:
cytosolic ros
mitochondrial ros
apoptosis
peroxiredoxin 5
glutamate
ht22
hyper
hydrogen peroxide
Online Access:http://dx.doi.org/10.1080/13510002.2021.1901028

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