Adiposity is associated with widespread transcriptional changes and downregulation of longevity pathways in aged skeletal muscle

Adiposity is associated with widespread transcriptional changes and downregulation of longevity pathways in aged skeletal muscle

Abstract Background Amongst healthy older people, a number of correlates of impaired skeletal muscle mass and function have been defined. Although the prevalence of obesity is increasing markedly in this age group, information is sparse about the particular impacts of obesity on ageing skeletal musc...

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Bibliographic Details
Main Authors: Mark A. Burton, Elie Antoun, Emma S. Garratt, Leo Westbury, Alica Baczynska, Elaine M. Dennison, Nicholas C. Harvey, Cyrus Cooper, Harnish P. Patel, Keith M. Godfrey, Karen A. Lillycrop, EpiGen Global Research Consortium
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
adiposity
AMPK
DNA methylation
gene expression
longevity
skeletal muscle
Online Access:https://doi.org/10.1002/jcsm.13255

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