Piezo Channels: Awesome Mechanosensitive Structures in Cellular Mechanotransduction and Their Role in Bone
Piezo channels are mechanosensitive ion channels located in the cell membrane and function as key cellular mechanotransducers for converting mechanical stimuli into electrochemical signals. Emerged as key molecular detectors of mechanical forces, Piezo channels’ functions in bone have attracted more...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/12/6429 |
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| author | Xia Xu Shuyu Liu Hua Liu Kang Ru Yunxian Jia Zixiang Wu Shujing Liang Zarnaz Khan Zhihao Chen Airong Qian Lifang Hu |
| author_facet | Xia Xu Shuyu Liu Hua Liu Kang Ru Yunxian Jia Zixiang Wu Shujing Liang Zarnaz Khan Zhihao Chen Airong Qian Lifang Hu |
| author_sort | Xia Xu |
| collection | DOAJ |
| description | Piezo channels are mechanosensitive ion channels located in the cell membrane and function as key cellular mechanotransducers for converting mechanical stimuli into electrochemical signals. Emerged as key molecular detectors of mechanical forces, Piezo channels’ functions in bone have attracted more and more attention. Here, we summarize the current knowledge of Piezo channels and review the research advances of Piezo channels’ function in bone by highlighting Piezo1′s role in bone cells, including osteocyte, bone marrow mesenchymal stem cell (BM-MSC), osteoblast, osteoclast, and chondrocyte. Moreover, the role of Piezo channels in bone diseases is summarized. |
| first_indexed | 2024-03-10T10:22:42Z |
| format | Article |
| id | doaj.art-acd4770d5aec44c3bdf9c5549b2a18b3 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:22:42Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-acd4770d5aec44c3bdf9c5549b2a18b32023-11-22T00:18:20ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012212642910.3390/ijms22126429Piezo Channels: Awesome Mechanosensitive Structures in Cellular Mechanotransduction and Their Role in BoneXia Xu0Shuyu Liu1Hua Liu2Kang Ru3Yunxian Jia4Zixiang Wu5Shujing Liang6Zarnaz Khan7Zhihao Chen8Airong Qian9Lifang Hu10Lab for Bone Metabolism, Key Lab for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, ChinaLab for Bone Metabolism, Key Lab for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, ChinaLab for Bone Metabolism, Key Lab for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, ChinaLab for Bone Metabolism, Key Lab for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, ChinaLab for Bone Metabolism, Key Lab for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, ChinaLab for Bone Metabolism, Key Lab for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, ChinaLab for Bone Metabolism, Key Lab for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, ChinaLab for Bone Metabolism, Key Lab for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, ChinaLab for Bone Metabolism, Key Lab for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, ChinaLab for Bone Metabolism, Key Lab for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, ChinaLab for Bone Metabolism, Key Lab for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, ChinaPiezo channels are mechanosensitive ion channels located in the cell membrane and function as key cellular mechanotransducers for converting mechanical stimuli into electrochemical signals. Emerged as key molecular detectors of mechanical forces, Piezo channels’ functions in bone have attracted more and more attention. Here, we summarize the current knowledge of Piezo channels and review the research advances of Piezo channels’ function in bone by highlighting Piezo1′s role in bone cells, including osteocyte, bone marrow mesenchymal stem cell (BM-MSC), osteoblast, osteoclast, and chondrocyte. Moreover, the role of Piezo channels in bone diseases is summarized.https://www.mdpi.com/1422-0067/22/12/6429Piezo channelsmechanotransductionbone cellsbone disease |
| spellingShingle | Xia Xu Shuyu Liu Hua Liu Kang Ru Yunxian Jia Zixiang Wu Shujing Liang Zarnaz Khan Zhihao Chen Airong Qian Lifang Hu Piezo Channels: Awesome Mechanosensitive Structures in Cellular Mechanotransduction and Their Role in Bone International Journal of Molecular Sciences Piezo channels mechanotransduction bone cells bone disease |
| title | Piezo Channels: Awesome Mechanosensitive Structures in Cellular Mechanotransduction and Their Role in Bone |
| title_full | Piezo Channels: Awesome Mechanosensitive Structures in Cellular Mechanotransduction and Their Role in Bone |
| title_fullStr | Piezo Channels: Awesome Mechanosensitive Structures in Cellular Mechanotransduction and Their Role in Bone |
| title_full_unstemmed | Piezo Channels: Awesome Mechanosensitive Structures in Cellular Mechanotransduction and Their Role in Bone |
| title_short | Piezo Channels: Awesome Mechanosensitive Structures in Cellular Mechanotransduction and Their Role in Bone |
| title_sort | piezo channels awesome mechanosensitive structures in cellular mechanotransduction and their role in bone |
| topic | Piezo channels mechanotransduction bone cells bone disease |
| url | https://www.mdpi.com/1422-0067/22/12/6429 |
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