Cancer Stem Cells Converted from Pluripotent Stem Cells and the Cancerous Niche
Nowadays, the cancer stem cells are considered to be significantly responsible for growth, metastasis, invasion and recurrence of all cancer. Cancer stem cells are typically characterized by continuous proliferation and self-renewal as well as by differentiation potential, while stem cells are consi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
GN Corporation Limited
2014-04-01
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| Series: | Journal of Stem Cells and Regenerative Medicine |
| Online Access: | http://www.pubstemcell.com/monthly/010010200002.htm |
| _version_ | 1818989765277515776 |
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| author | Kasai T Chen L Mizutani AZ Kudoh T Murakami H Fu L Seno M |
| author_facet | Kasai T Chen L Mizutani AZ Kudoh T Murakami H Fu L Seno M |
| author_sort | Kasai T |
| collection | DOAJ |
| description | Nowadays, the cancer stem cells are considered to be significantly responsible for growth, metastasis, invasion and recurrence of all cancer. Cancer stem cells are typically characterized by continuous proliferation and self-renewal as well as by differentiation potential, while stem cells are considered to differentiate into tissue- specific phenotype of mature cells under the influence of micro-environment. Cancer stem cells should be traced to the stem cells under the influence of a micro-environment, which induces malignant tumors. In this review, we propose this micro-environment as a 'cancerous niche' and discuss its importance on the formation and maintenance of cancer stem cells with the recent experimental results to establish cancer stem cell models from induced pluripotent stem cells. These models of cancer stem cell will provide the great advantages in cancer research and its therapeutic applications in the future. |
| first_indexed | 2024-12-20T19:43:40Z |
| format | Article |
| id | doaj.art-acd505c985904a9f84c6164b1cdd8c6d |
| institution | Directory Open Access Journal |
| issn | 0973-7154 0973-7154 |
| language | English |
| last_indexed | 2024-12-20T19:43:40Z |
| publishDate | 2014-04-01 |
| publisher | GN Corporation Limited |
| record_format | Article |
| series | Journal of Stem Cells and Regenerative Medicine |
| spelling | doaj.art-acd505c985904a9f84c6164b1cdd8c6d2022-12-21T19:28:28ZengGN Corporation LimitedJournal of Stem Cells and Regenerative Medicine0973-71540973-71542014-04-0110127Cancer Stem Cells Converted from Pluripotent Stem Cells and the Cancerous NicheKasai T0Chen L1Mizutani AZ2Kudoh T3Murakami H4Fu L5Seno M6Department of Biotechnology, Graduate School of Natural Science and Technology, Okayama University, Okayama, JapanDepartment of Pathology, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin, ChinaDepartment of Biotechnology, Graduate School of Natural Science and Technology, Okayama University, Okayama, JapanDepartment of Biotechnology, Graduate School of Natural Science and Technology, Okayama University, Okayama, JapanDepartment of Biotechnology, Graduate School of Natural Science and Technology, Okayama University, Okayama, JapanDepartment of Breast Cancer Pathology and Research laboratory of Cancer Hospital, Tianjin Medical University, Tianjin, China.Department of Biotechnology, Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan;Nowadays, the cancer stem cells are considered to be significantly responsible for growth, metastasis, invasion and recurrence of all cancer. Cancer stem cells are typically characterized by continuous proliferation and self-renewal as well as by differentiation potential, while stem cells are considered to differentiate into tissue- specific phenotype of mature cells under the influence of micro-environment. Cancer stem cells should be traced to the stem cells under the influence of a micro-environment, which induces malignant tumors. In this review, we propose this micro-environment as a 'cancerous niche' and discuss its importance on the formation and maintenance of cancer stem cells with the recent experimental results to establish cancer stem cell models from induced pluripotent stem cells. These models of cancer stem cell will provide the great advantages in cancer research and its therapeutic applications in the future.http://www.pubstemcell.com/monthly/010010200002.htm |
| spellingShingle | Kasai T Chen L Mizutani AZ Kudoh T Murakami H Fu L Seno M Cancer Stem Cells Converted from Pluripotent Stem Cells and the Cancerous Niche Journal of Stem Cells and Regenerative Medicine |
| title | Cancer Stem Cells Converted from Pluripotent Stem Cells and the Cancerous Niche |
| title_full | Cancer Stem Cells Converted from Pluripotent Stem Cells and the Cancerous Niche |
| title_fullStr | Cancer Stem Cells Converted from Pluripotent Stem Cells and the Cancerous Niche |
| title_full_unstemmed | Cancer Stem Cells Converted from Pluripotent Stem Cells and the Cancerous Niche |
| title_short | Cancer Stem Cells Converted from Pluripotent Stem Cells and the Cancerous Niche |
| title_sort | cancer stem cells converted from pluripotent stem cells and the cancerous niche |
| url | http://www.pubstemcell.com/monthly/010010200002.htm |
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